Altered retinal nerve fiber layer thickness in children with allergic conjunctivitis: the Nanjing eye study

Chen, Danni; Li, Rui; Huang, Dan; Tong, Haohai; Zhao, Xiaoyan; Yuan, Wen; Shen, Shiya; Liu, Hu; Zhu, Hui

doi:10.1186/s12886-022-02399-7

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…Chen D et al reported a thinner retinal nerve ber layer (RNFL) in patients with allergic conjunctivitis (AC) [30]. The same study showed no signi cant difference in macular thickness measurements among AC patients compared to the control group.…”

Section: Discussionmentioning

confidence: 91%

Choroidal and retinal changes in patients with allergic rhinoconjunctivitis

Akçal,

Suleymanzade,

Işık

et al. 2024

Pam Tıp Derg

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Purpose: Allergic rhinoconjunctivitis (ARC) is an allergic upper respiratory tract disease characterized by sneezing, runny nose, nasal congestion and ocular and nasal itching due to inflammation of the nasal and conjunctival mucosa. There are no studies evaluating both the choroidal and retinal areas in ARC patients. Our objective was to evaluate patients with ARC at the time of diagnosis and before initiating treatment using Optical Coherence Tomography (OCT). Material and methods: This prospective cross-sectional study included 30 patients with ARC who presented to the Pediatric Allergy & Immunology Outpatient Clinic and 30 healthy control individuals. OCT scans were captured with Cirrus HD OCT-5000 (Carl Zeiss, Jena, Germany) in the enhanced depth imaging (EDI) mode. Results: Of the study population, 66.7% (n=20) of patient group and 56.6% (n=17) of control group were female. The mean age was 13±2.3 and 13.9±1.8 years in the patient and control groups, respectively. The temporal subfoveal choroidal thickness was statistically significantly thinner in ARC patients with asthma (p=0.032). A robust negative correlation was found between minimum ganglion cell-inner plexiform layer (GCIPL) thickness and absolute eosinophil count (AEC) in patients with ARC (r: -0.551, p

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Section: Discussionmentioning

confidence: 91%

Choroidal and retinal changes in patients with allergic rhinoconjunctivitis

Akçal,

Suleymanzade,

Işık

et al. 2024

Pam Tıp Derg

View full text Add to dashboard Cite

show abstract

“…Chen D et al reported a thinner retinal nerve fiber layer (RNFL) in patients with allergic conjunctivitis (AC) (30). The same study showed no significant difference in macular thickness measurements among AC patients compared to the control group.…”

Section: Discussionmentioning

confidence: 92%

Choridal and Retinal Changes in Patients With Allergic Rhinoconjunctivitis

Akcal,

Suleymanzade,

Isık

et al. 2024

Preprint

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Background: Allergic rhinoconjunctivitis (ARC) is an allergic upper respiratory tract disease characterized by sneezing, runny nose, nasal congestion and ocular and nasal itching due to inflammation of the nasal and conjunctival mucosa. There are no studies evaluating both the choroidal and retinal areas in ARC patients. Our objective was to evaluate patients with ARC at the time of diagnosis and before initiating treatment using Optical Coherence Tomography (OCT). Methods: This prospective cross-sectional study included 30 patients with ARC who presented to the Pediatric Allergy & Immunology Outpatient Clinic and 30 healthy control individuals. OCT scans were captured with Cirrus HD OCT-5000 (Carl Zeiss, Jena, Germany) in the enhanced depth imaging (EDI) mode. Results: Of the study population, 66.7% (n=20) of patient group and 56.6% (n=17) of control group were female. The mean age was 13±2.3 and 13.9±1.8 years in the patient and control groups, respectively. The temporal subfoveal choroidal thickness was statistically significantly thinner in ARC patients with asthma (p=0.032). A robust negative correlation was found between minimum ganglion cell-inner plexiform layer (GCIPL) thickness and allergic eosinophil count (AEC) in patients with ARC (r: -0.551, p<0.0001). Conclusion: In our study, the GCIPL thickness was lower in ARC patients. Similarly, although it did not reach statistical significance, the minimum GCIPL thickness was lower in our patient group with asthma compared to those without asthma. Our results suggest that multiple allergen sensitization and elevated eosinophils may influence GCIP thickness. However, both choroidal and retinal tissue might be impacted during chronic follow-up. Further studies are needed to support these findings. Keymessage: Multiple allergen sensitization and elevated eosinophil levels contribute to GCIPL thickness in ARC patients.

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“…The direct effect of topical corticosteroids and the RNFL thickness needs more research and until strong evidence suggests that topical corticosteroids affect the RNFL, we do not consider short-term use of uoromethalone 0.1% as a major confounding factor. The association between the retinal nerve bre layer and allergic conjunctivitis also requires further research as a single study reported a slightly thinner RNFL in Chinese children with allergic conjunctivitis (42). We did not consider the in uence of other optic nerve head parameters on the RNFL thickness.…”

Section: Strengths and Limitationsmentioning

confidence: 94%

South African Eye Study: Establishing a normative database for retinal nerve fibre layer thickness in a black ethnicity paediatric population

Govender,

Baboolal

2024

Preprint

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Background: The retinal nerve fibre layer (RNFL) thickness in South African children of black ethnicity is not known. Current imaging devices do not include a paediatric normative database. There is also a lack of data on global majority ethnicities. This study used spectral-domain optical coherence tomography (SD-OCT) to describe the average and quadrant RNFL thickness in children of black ethnicity. Methods: A prospective cross-sectional hospital-based study was conducted at McCord Provincial Eye Hospital, Durban, South Africa, with a convenience-based sampling strategy. One normal eye from children between the ages of 5 and 18 were selected. An ocular examination included an autorefraction and an axial length measurement. The RNFL thickness was measured with the iVue-100 SD-OCT™. Results:Seventy-three children were enrolled in this study based on power calculations. The mean (standard deviation) average RNFL thickness was 107.31um (8.1). The mean (standard deviation) inferior, superior, nasal, and temporal quadrant thickness were as follows: 135.1um (13.65), 135.6um (14.59), 83.2um (10.86), and 75.4um (9.03). No correlation was found between the average RNFL thickness and age, sex, spherical equivalent, and axial length with a p-value of 0.438, 0.106, 0.632, and 0.20 respectively. Conclusion: This study described the normative values for retinal nerve fibre layer thickness using SD-OCT in South African children of black ethnicity between 5 and 18 years old and supports paediatric ethnic variation in the RNFL thickness. Establishing a normative database could help screen, diagnose and monitor glaucoma and other optic nerve pathologies in this paediatric ethnic group.

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Altered retinal nerve fiber layer thickness in children with allergic conjunctivitis: the Nanjing eye study

Cited by 5 publications

References 43 publications

Choroidal and retinal changes in patients with allergic rhinoconjunctivitis

Choroidal and retinal changes in patients with allergic rhinoconjunctivitis

Choridal and Retinal Changes in Patients With Allergic Rhinoconjunctivitis

South African Eye Study: Establishing a normative database for retinal nerve fibre layer thickness in a black ethnicity paediatric population

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