Altered sensitivity to ellagic acid in neuroblastoma cells undergoing differentiation with 12-O-tetradecanoylphorbol-13-acetate and all-trans retinoic acid

Alfredsson, Christina Fjæraa; Rendel, Filip; Liang, Qui-Li; Sundström, Birgitta; Nånberg, Eewa

doi:10.1016/j.biopha.2015.10.008

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Previous studies have demonstrated that TPA enhances cell migration through activating protein kinase C (PKC) in several types of tumor cells467. As a PKC activator, TPA also inhibits the apoptosis induced by Fas/FasL in human promyelocytic leukemia cells9.…”

Section: Discussionmentioning

confidence: 99%

“…Commonly, TPA is employed as a tumor-promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation in malignant cells from several types of tumors, such as melanoma and breast and oral cancer345. However, the function of TPA is controversial because a decrease in cell proliferation capacity has also been observed in TPA-treated lymphoma cells compared to controls67. Hence, different effects may occur after exposure to TPA in different types of cells.…”

mentioning

confidence: 99%

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12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT

Zhu¹,

Chen²,

Zhang³

et al. 2017

Sci Rep

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TPA stimulates carcinogenesis in various types of cancers. However, we found that TPA inhibits transformative phenotypes in liver cancer cells via the translocation of YAP from the nucleus, where it functions as a transcriptional co-factor, to the cytoplasm. Such effects led to a separation of YAP from its dependent transcription factors. The inhibitory effects of TPA on YAP were AMOT dependent. Without AMOT, TPA was unable to alter YAP activity. Importantly, the depletion of YAP and AMOT blocked the TPA-reduced transformative phenotypes. In sum, TPA has been established as an anti-tumorigenic drug in liver cancer cells via YAP and AMOT.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT

Zhu¹,

Chen²,

Zhang³

et al. 2017

Sci Rep

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“…reduction of the number of human neuroblastoma SH-SY5Y cells by alterations of the mitochondrial membrane potential, activation of Casp-3, Casp-9, fragmentation of DNA, and dose- and time-dependent cell apoptosis by the mitochondrial pathway [102,103];…”

Section: Figurementioning

confidence: 99%

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

2017

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The neuroprotective role of phenolic acids from food has previously been reported by many authors. In this review, the role of phenolic acids in ameliorating depression, ischemia/reperfusion injury, neuroinflammation, apoptosis, glutamate-induced toxicity, epilepsy, imbalance after traumatic brain injury, hyperinsulinemia-induced memory impairment, hearing and vision disturbances, Parkinson’s disease, Huntington’s disease, anti-amyotrophic lateral sclerosis, Chagas disease and other less distributed diseases is discussed. This review covers the in vitro, ex vivo and in vivo studies concerning the prevention and treatment of neurological disorders (on the biochemical and gene expression levels) by phenolic acids.

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“…1, the 144 hr cultures and fig. 3), cells received new complete culture medium with additions at day 4, in agreement with the established differentiation protocol [24]. For the NPY peptide ELISA measurement, a medium change at day 4 and a subsequent 16 hr incubation was included to avoid carryover of released NPY peptide produced at the beginning of treatment at the time for measurement.…”

Section: R E T R a C T E Dmentioning

confidence: 99%

Retracted: Effects of Di‐isononyl Phthalate on Neuropeptide Y Expression in Differentiating Human Neuronal Cells

Rendel

Alfredsson

Bornehag

et al. 2017

Basic Clin Pharma Tox

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Neuropeptide Y (NPY) is an abundant neuropeptide in the mammalian brain important for behavioural consequences of stress and energy metabolism. We have addressed possible effects of the phthalate DiNP on NPY expression in human SH-SY5Y cells, a neuronal in vitro differentiation model. Pico- to nanomolar doses of DiNP and its metabolite MiNP resulted in decreased NPY mRNA and peptide expression in retinoid-differentiated cells. Thus, dys-regulated NPY may be an adverse outcome for exposure to low doses of DiNP in human beings.

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Altered sensitivity to ellagic acid in neuroblastoma cells undergoing differentiation with 12-O-tetradecanoylphorbol-13-acetate and all-trans retinoic acid

Cited by 9 publications

References 33 publications

12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT

12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

Retracted: Effects of Di‐isononyl Phthalate on Neuropeptide Y Expression in Differentiating Human Neuronal Cells

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