Altered spontaneous brain activity patterns in patients with neovascular glaucoma using amplitude of low‐frequency fluctuations: A functional magnetic resonance imaging study

Peng, Zhi-You; Liu, Yuxin; Li, Biao; Ge, Qian‐Min; Liang, Rong‐Bin; Li, Qiuyu; Shi, Wen‐Qing; Yan, Yu; Shao, Yi

doi:10.1002/brb3.2018

Cited by 12 publications

(11 citation statements)

References 45 publications

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“…In addition to the IFG, many studies have also shown that optic diseases are associated with dysfunction in the SFG (Min et al, 2018;Xu et al, 2019;Wang et al, 2021). The SFG occupies one-third of the frontal lobe and is thought to be the main premotor area (Peng et al, 2021). It plays roles in working memory presentation of visual space (Leavitt et al, 2018), and is also related to acute social stress (Chang and Yu, 2019), cognitive control (Tully et al, 2014), and self-consciousness (Hsieh et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Altered Brain Functional Connectivity at Resting-State in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy

Zhao

Guo

et al. 2021

Front. Neurosci.

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Purpose: To investigate the possible changes in functional connectivity (FC) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) using resting-state functional MRI (fMRI).Methods: Thirty-one NAION patients and 31 healthy controls were recruited and underwent resting-state fMRI scans. Regions of interest (ROIs) were defined as bilateral Brodmann’s area 17 (BA17). FC analysis was performed between the ROIs and the rest of the brain regions, and the between group comparisons of FC were performed. We conducted correlation analysis between the FC changes and the clinical variables in NAION patients.Results: Compared with healthy controls, patients with NAION showed significantly decreased FC between the left BA17 and the right inferior frontal gyrus, left caudate nucleus. As for the right BA17, patients exhibited significantly increased FC with the left olfactory gyrus and decreased FC with the right superior frontal gyrus (SFG), right insula. Moreover, FC values between the right insula and the right BA17 were positively correlated with the right side of mean sensitivity in the central visual field (r = 0.52, P < 0.01) and negatively correlated with the right side of mean defect in the central visual field (r = −0.55, P < 0.01).Conclusion: Our study indicated that patients with NAION showed significantly abnormal functional reorganization between the primary visual cortex and several other brain regions not directly related to visual function, which supports that NAION may not only be an ophthalmic disease but also a neuro-ophthalmological disease.

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Section: Discussionmentioning

confidence: 99%

Altered Brain Functional Connectivity at Resting-State in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy

Zhao

Guo

et al. 2021

Front. Neurosci.

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“…Moreover, when NVG progresses to stage III, a series of symptoms such as vasoconstriction, peripheral conjunctival adhesions, as well as corneal swelling and congestion, severely damage the patient’s vision. In addition, an increase in intraocular pressure (IOP) is accompanied by severe eye pain ( Peng et al, 2021 ). Thus, NVG patients have difficulty in visual recognition, which may lead to a compensatory increase in ITG activity, including ITG.L.…”

Section: Discussionmentioning

confidence: 99%

“…Neovascular glaucoma (NVG) is a secondary eye disease caused by a variety of ocular and systemic diseases and is closely related to retinal ischemia and hypoxia caused by diseases. Three of the most common causative conditions of NVG are ischemic central retinal vein occlusion (CRVO) (33%), diabetic retinopathy (DR) (33%), and ocular ischemic syndrome (13%) ( Peng et al, 2021 ). Clinically, NVG can manifest as increased intraocular pressure, photophobia, severe eye pain, corneal swelling, and iris erythema, causing irreversible visual impairment and severely affecting the lives of patients worldwide.…”

Section: Introductionmentioning

confidence: 99%

Altered Resting State Functional Activity of Brain Regions in Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study

et al. 2021

Front. Neurosci.

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Background: Neovascular glaucoma (NVG) is a serious eye disease that causes irreversible damage to the eye. It can significantly increase intraocular pressure and cause severe pain, as well as abnormal activity in the cortical and pre-cortical visual systems. However, there are few studies in this area. This trial assessed the altered regional brain activity in patients with NVG using the percentage of fluctuation amplitude (PerAF) method.Methods: Resting-state functional MRI (rs-fMRI) scans were conducted in 18 individuals with NVG and 18 healthy controls (HCs), matched for education level, gender, and age. The PerAF method was applied to assess brain activity. Mean PerAF values of brain regions in NVG and HCs were compared using receiver operating characteristic (ROC) curves.Results: Lower PerAF values were found in the NVG group than in controls in the right anterior cingulate and paracingulate gyri (ACG.R), right superior occipital gyrus (SOG.R) and left superior frontal gyrus (orbital part) (ORBsup.L) (p < 0.001). In contrast, PerAF value was higher in NVG patients than in controls in the left inferior temporal gyrus (ITG.L) (p < 0.001). The hospital anxiety and depression scale (HADS) and visual analog score (VAS) were significantly and positively correlated with PerAF in ITG.L (r = 0.9331, p < 0.0001; and r = 0.7816, p = 0.0001, respectively).Conclusion: Abnormal activity in the patient’s brain regions further confirms that the NVG affects the entire brain, not just the visual pathways and posterior retinal mechanisms (including the hypothalamic lateral geniculate nucleus and the primary visual cortex). This strengthens our understanding of the NVG and provides potential diagnostic and therapeutic support for patients who are difficult to diagnose and treat early.

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“…Structural neuroimaging, including voxel-based morphometry (VBM) and diffusion tensor imaging (DTI), indicates an atrophic optic nerve (ON) and lateral geniculate body (LGN), damaged optic radiation (OR), and a thinning visual cortex in glaucoma patients [ 6 – 9 ]. Functional magnetic resonance imaging (fMRI) has demonstrated several forms of visual task-related deactivation in glaucoma [ 10 ], including decreased visual functional connectivity (FC) [ 11 ], decreased and/or increased amplitude of low-frequency fluctuations (ALFF) in the cuneus and occipital lobe/inferior temporal gyrus [ 12 – 14 ], and decreased regional homogeneity (ReHo) in the calcarine area [ 15 ]. In addition, structural and functional studies have indicated alterations in the extravisual system, such as the hippocampus [ 16 ], anterior thalamic radiation, superior longitudinal fascicle [ 17 ], and executive network [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Brain Functional Network Analysis of Patients with Primary Angle-Closure Glaucoma

et al. 2022

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Objectives. Recent resting-state functional magnetic resonance imaging (fMRI) studies have focused on glaucoma-related neuronal degeneration in structural and spontaneous functional brain activity. However, there are limited studies regarding the differences in the topological organization of the functional brain network in patients with glaucoma. In this study, we aimed to assess both potential alterations and the network efficiency in the functional brain networks of patients with primary angle-closure glaucoma (PACG). Methods. We applied resting-state fMRI data to construct the functional connectivity network of 33 patients with PACG ( 54.21 ± 7.21 years ) and 33 gender- and age-matched healthy controls ( 52.42 ± 7.80 years ). The differences in the global and regional topological brain network properties between the two groups were assessed using graph theoretical analysis. Partial correlations between the altered regional values and clinical parameters were computed for patients with PACG. Results. No significant differences in global topological measures were identified between the two groups. However, significant regional alterations were identified in the patients with PACG, including differences within visual and nonvisual (somatomotor and cognition-emotion) regions. The normalized clustering coefficient and normalized local efficiency of the right superior parietal gyrus were significantly correlated with the retinal fiber layer thickness (RNFLT) and the vertical cup to disk ratio (V C/D). In addition, the normalized node betweenness of the left middle frontal gyrus (orbital portion) was significantly correlated with the V C/D in the patients with PACG. Conclusions. Our results suggest that regional inefficiency with decrease and compensatory increase in local functional properties of visual and nonvisual nodes preserved the brain network of the PACG at the global level.

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Altered spontaneous brain activity patterns in patients with neovascular glaucoma using amplitude of low‐frequency fluctuations: A functional magnetic resonance imaging study

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 12 publications

References 45 publications

Altered Brain Functional Connectivity at Resting-State in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy

Altered Brain Functional Connectivity at Resting-State in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy

Altered Resting State Functional Activity of Brain Regions in Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study

Brain Functional Network Analysis of Patients with Primary Angle-Closure Glaucoma

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