Altered temporal variance and functional connectivity of BOLD signal is associated with state anxiety during acute systemic inflammation

Labrenz, Franziska; Ferri, Francesca; Wrede, Karsten H.; Forsting, Michael; Schedlowski, Manfred; Engler, Harald; Elsenbruch, Sigrid; Benson, Sven; Costantini, Marcello

doi:10.1016/j.neuroimage.2018.09.056

Cited by 36 publications

(15 citation statements)

References 79 publications

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“…In addition, growing evidence suggests that the insular cortex, a key node of the SAN, and its functional link to other brain regions play a crucial role in the central representation of inflammation [35][36][37] as well as anxiety or depression 36,38 . Specifically, our findings of reduced functional connectivity regarding the SAN that are also associated with greater PTS symptom severity may be consistent with previous studies that have noted decreased SAN connectivity following induced transient systemic inflammation 39 , as well as the interaction effect between functional connectivity of the brain with clinical symptom severity 18 .…”

Section: Discussionsupporting

confidence: 92%

A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms

et al. 2020

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Growing evidence indicates a reciprocal relationship between low-grade systemic inflammation and stress exposure towards increased vulnerability to neuropsychiatric disorders, including posttraumatic stress disorder (PTSD). However, the neural correlates of this reciprocity and their influence on the subsequent development of PTSD are largely unknown. Here we investigated alterations in functional connectivity among brain networks related to low-grade inflammation and stress exposure using two large independent data sets. Functional couplings among the higher-order cognitive network system including the salience, default mode, and central executive networks were reduced in association with low-grade inflammation and stress exposure. This reduced functional coupling may also be related to subsequent posttraumatic stress symptom severity. The current findings propose functional couplings among the higher-order cognitive network system as neural correlates of low-grade inflammation and stress exposure, and suggest that low-grade inflammation, alongside with stress, may render individuals more vulnerable to PTSD.

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Section: Discussionsupporting

confidence: 92%

A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms

et al. 2020

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“…The NAcc also plays a role in fear conditioning and FE (Fullana et al, 2018). The increasing variance appeared consistent with prior literature showing a positive association between increasing variance and functional efficiency during active cognitive tasks (Garrett et al, 2012(Garrett et al, , 2018Labrenz et al, 2019). The thalamic nuclei were associated with visual (BN-239-PPtha-L) and action execution (BN-233-PMtha-L) functions (Fan et al, 2016 3 ), and their changes in variability seemed related to the experimental environment.…”

Section: Changes In the Variance Of The Bold Signal After Fear Learnisupporting

confidence: 85%

“…Therefore, we expected a decrease of the scaling exponent during fear extinction in the fear-processing brain network, similar to the findings on its suppression with cognitive load (Barnes et al, 2009;Churchill et al, 2016). Simultaneously, we hypothesized that the variance should increase during the task as an indirect index of neural efficiency (Labrenz et al, 2019). We also expected to find residual changes of both LRTC and variance in areas of fear-processing brain network in the post-task resting state, as it was early reported for functional connectivity of the BOLD signal (Schultz et al, 2012;Feng et al, 2015;Martynova et al, 2020).…”

Section: Introductionsupporting

confidence: 72%

“…Few papers have shown a positive relation of anxiety scores and the BOLD signal LRTC of brain regions involved in emotional and cognitive processing (Tolkunov et al, 2010;Churchill et al, 2015). The increase of the amygdala's temporal variance was found to be associated with state anxiety and functional connectivity of the BOLD signal during acute systemic inflammation (Labrenz et al, 2019). Nevertheless, to our knowledge, there were no direct studies of task-based and resting-state fMRI fractality and variance behavior induced by fear conditioning paradigms.…”

Section: Introductionmentioning

confidence: 85%

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Variance and Scale-Free Properties of Resting-State Blood Oxygenation Level-Dependent Signal After Fear Memory Acquisition and Extinction

Tetereva

Kartashov

Ivanitsky

et al. 2020

Front. Hum. Neurosci.

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Recently, the dynamic properties of brain activity rather than its stationary values have attracted more interest in clinical applications. It has been shown that brain signals exhibit scale-free dynamics or long-range temporal correlations (LRTC) that differ between rest and cognitive tasks in healthy controls and clinical groups. Little is known about how fear-inducing tasks may influence dispersion and the LRTC of subsequent resting-state brain activity. In this study, we aimed to explore the changes in the variance and scale-free properties of the brain's blood oxygenation level-dependent (BOLD) signal during the resting-state sessions before and after fear learning and fear memory extinction. During a 1-h break between magnetic resonance imaging (MRI) scanning, 23 healthy, right-handed volunteers experienced a fear extinction procedure, followed by Pavlovian fear conditioning that included partial reinforcement using mild electrical stimulation. We extracted the average time course of the BOLD signal from 245 regions of interest (ROIs) taken from the resting-state functional atlas. The variance of the BOLD signal and the Hurst exponent (H), which reflects the scale-free dynamic, were compared in the resting states before and after fear learning and fear memory extinction. After fear extinction, six ROIs showed a difference in H at the uncorrected level of significance, including areas associated with fear processing. H decreased during fear extinction but then became higher than before fear learning, specifically in areas related to the fear extinction network (FEN). However, activity in the other ROIs restored the H to its initial level. The variance of the BOLD signal in six ROIs demonstrated a significant increase from initial rest to the post-task rest. A limited number of ROIs showed changes in both H and variance. Our results imply that the variability and scale-free properties of the BOLD signal might serve as additional indicators of changes in spontaneous brain activity related to recent experience.

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“…For example, it has been demonstrated that the variance of the task-evoked BOLD response was differentially related to aging as well as cognitive performance (Armbruster-Genc et al, 2016;Garrett et al, 2013a). Similarly, spontaneous signal variability in resting state fMRI (rsfMRI) has been associated with age (Grady and Garrett, 2018;Nomi et al, 2017), emotional state (state anxiety; Labrenz et al, 2018), and mental or neural disorders such as stroke (Kielar et al, 2016), Attention Deficit Hyperactivity Disorder (Nomi et al, 2018) or 22q11.2 deletion syndrome (Zöller et al, 2017). From these studies, it was concluded that reductions in BOLD signal variability might serve as an index for deficits in neural processing and cognitive flexibility (Grady and Garrett, 2014).…”

Section: Introductionmentioning

confidence: 99%

BOLD and EEG Signal Variability at Rest Differently Relate to Aging in the Human Brain

Kumral

Sansal

Cesnaite

et al. 2019

Preprint

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Variability of neural activity is regarded as a crucial feature of healthy brain function, and several neuroimaging approaches have been employed to assess it noninvasively. Studies on the variability of both evoked brain response and spontaneous brain signals have shown remarkable changes with aging but it is unclear if the different measures of brain signal variability -identified with either hemodynamic or electrophysiological methods -reflect the same underlying physiology. In this study, we aimed to explore age differences of spontaneous brain signal variability with two different imaging modalities (EEG, fMRI) in healthy younger (25±3 years, N=135) and older (67±4 years, N=54) adults. Consistent with the previous studies, we found lower blood oxygenation level dependent (BOLD) variability in the older subjects as well as less signal variability in the amplitude of low-frequency oscillations (1-12 Hz), measured in source space. These age-related reductions were mostly observed in the areas that overlap with the default mode network. Moreover, age-related increases of variability in the amplitude of beta-band frequency EEG oscillations (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) were seen predominantly in fronto-temporal and sensorimotor brain regions. There were significant sex differences in BOLD and EEG signal variability in various brain regions, but no significant interactions between age and sex were observed. Further, both univariate and multivariate correlation analyses revealed no significant associations between these two variability measures. In summary, we show that both BOLD and EEG signal variability reflect aging-related processes but are likely to be dominated by different physiological origins, which relate differentially to age and sex.

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Altered temporal variance and functional connectivity of BOLD signal is associated with state anxiety during acute systemic inflammation

Abstract: Altered temporal variance and functional connectivity of BOLD signal is associated with state anxiety during acute systemic inflammation Short title: Neural variance and state anxiety during acute inflammation

Cited by 36 publications

References 79 publications

A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms

A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms

Variance and Scale-Free Properties of Resting-State Blood Oxygenation Level-Dependent Signal After Fear Memory Acquisition and Extinction

BOLD and EEG Signal Variability at Rest Differently Relate to Aging in the Human Brain

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