Altered Uric Acid Levels and Disease States

NLRP3 inflammasome–mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout

“…The amount of endotoxin present in the MSU crystals injected was Ͻ5 pg (at the higher dose), as assessed using a Chromogenic Limulus amebocyte lysate assay (Endosafe). Inflammation parameters were evaluated at different time points after injection of the MSU crystals (1,3,6,15, and 24 hours after injection), and mechanical hypernociception was also evaluated at various time points after injection.…”

“…Gout is caused by deposition of urate crystals, a byproduct of purine degradation, in the joints and kidneys (1). The prevalence of gout and of elevated levels of free uric acid in the serum of patients (hyperuricemia) has increased in the last century, and it is estimated that more than 1% of adult men in Western countries have gout (2).…”

Identification of a New Urate and High Affinity Nicotinate Transporter, hOAT10 (SLC22A13)

“…44). Nowadays, urate comes back into clinical focus, because of its impact on cardiovascular and neurodegenerative diseases (45). Transporters currently known to play a significant role on urate plasma levels have recently been identified as URAT1, Oat1, Oat3, and glucose transporter 9 (GLUT9, SLC2A9), determined via knock-out mouse models or single nucleotide polymorphisms in man (15, 46 -48).…”

Ürik Asidin Antioksidan ve Pro-Oksidan Özellikleri ile İlgili Kavram ve Tartışmalarının Derlemesi

“…On the other hand, if UA was a harmful/waste product, it would not explain how the kidneys recover 90% of filtered UA 7 , instead of eliminating it. The evolution of hominids and the physiology of renal urate balance indicate that uric acid is something beneficial that we must retain instead of something harmful that has to be removed.…”