Alternaria alternata acts on human Monocyte-derived Dendritic cells to mediate Th2/Th17 polarisation

Loghmani, Alireza; Raoofi, Rahim; Ownagh, Abdulghaffar; Delirezh, Nowruz

doi:10.1016/j.aller.2016.07.005

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…In the CSF, Corynebacterium sanguinis , Leuconostoc lactis , Stenotrophomonas bentonitica A , Veillonella parvula A and UBA2031 sp003543245 were found to have higher abundance in non-NBM group, while Alternaria alternata , Kocuria rosea and Staphylococcus pettenkoferi were found to have a higher abundance in NBM group. Notably, Alternaria alternata is a species of ascomycete fungi within the Pleosporaceae family, which is associated with allergic asthma or allergic pneumonia ( Stern et al., 2008 ; Loghmani et al., 2017 ) and has been identified as an infectious agent in cases of mycotic keratitis, particularly in association with soft contact lenses and corneal transplantation ( Huerva and Soldevila, 2017 ). Kocuria rosea and Staphylococcus pettenkoferi can also be an opportunistic pathogen ( Ahmad-Mansour et al., 2021 ), causing infections in immunocompromised patients ( Villafañe et al., 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Microbial signatures of neonatal bacterial meningitis from multiple body sites

Hou,

Zhang,

Jiang

et al. 2023

Front. Cell. Infect. Microbiol.

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As a common central nervous system infection in newborns, neonatal bacterial meningitis (NBM) can seriously affect their health and growth. However, although metagenomic approaches are being applied in clinical diagnostic practice, there are some limitations for whole metagenome sequencing and amplicon sequencing in handling low microbial biomass samples. Through a newly developed ultra-sensitive metagenomic sequencing method named 2bRAD-M, we investigated the microbial signatures of central nervous system infections in neonates admitted to the neonatal intensive care unit. Particularly, we recruited a total of 23 neonates suspected of having NBM and collected their blood, cerebrospinal fluid, and skin samples for 2bRAD-M sequencing. Then we developed a novel decontamination method (Reads Level Decontamination, RLD) for 2bRAD-M by which we efficiently denoised the sequencing data and found some potential biomarkers that have significantly different relative abundance between 12 patients that were diagnosed as NBM and 11 Non-NBM based on their cerebrospinal fluid (CSF) examination results. Specifically, we discovered 11 and 8 potential biomarkers for NBM in blood and CSF separately and further identified 16 and 35 microbial species that highly correlated with the physiological indicators in blood and CSF. Our study not only provide microbiological evidence to aid in the diagnosis of NBM but also demonstrated the application of an ultra-sensitive metagenomic sequencing method in pathogenesis study.

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Section: Discussionmentioning

confidence: 99%

Microbial signatures of neonatal bacterial meningitis from multiple body sites

Hou,

Zhang,

Jiang

et al. 2023

Front. Cell. Infect. Microbiol.

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“…A. alternata promotes the production of IL-4, IL-10, and IL-6 in antigen-presenting cells (APCs), together with an increase in the expression of MHC class-II, CD40, CD80, and OX40L, which are costimulatory molecules implicated in type 2 development, in in vitro approximations [ 70 ]. Moreover, Alternaria can inhibit the endosome receptor TLR3 and the production of IFN-beta, IP-10, and I-TAC to inhibit defense mechanisms for viral and fungal infections [ 71 ].…”

Section: Immunological Mechanism Of Alternaria Actionmentioning

confidence: 99%

Alternaria as an Inducer of Allergic Sensitization

Hernández-Ramírez

Barber

Tomé-Amat

et al. 2021

JoF

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Alternaria alternata is a saprophytic mold whose spores are disseminated in warm dry air, the typical weather of the Mediterranean climate region (from 30° to 45°), with a peak during the late summer and early autumn. Alternaria spores are known to be biological contaminants and a potent source of aeroallergens. One consequence of human exposure to Alternaria is an increased risk of developing asthma, with Alt a 1 as its main elicitor and a marker of primary sensitization. Although the action mechanism needs further investigation, a key role of the epithelium in cytokine production, TLR-activated alveolar macrophages and innate lymphoid cells in the adaptive response was demonstrated. Furthermore, sensitization to A. alternata seems to be a trigger for the development of co-sensitization to other allergen sources and may act as an exacerbator of symptoms and an elicitor of food allergies. The prevalence of A. alternata allergy is increasing and has led to expanding research on the role of this fungal species in the induction of IgE-mediated respiratory diseases. Indeed, recent research has allowed new perspectives to be considered in the assessment of exposure and diagnosis of fungi-induced allergies, although more studies are needed for the standardization of immunotherapy formulations.

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