Alternative Medicine

Tausk, Francisco

doi:10.1001/archderm.134.11.1422

Cited by 23 publications

(4 citation statements)

References 35 publications

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“…Proponents of the health benets of plant-based medicines oen proclaim that whole plant preparations are more effective than isolated compounds due to the benecial interactions between constituents within them. 9,18,70,71 While this claim is sometimes disputed, [72][73][74][75] considerable evidence exists that combination effects within complex extracts can alter the biological activity of a mixture. [7][8][9]76 Here, we provide a few case studies in which synergy and/or antagonism within botanical preparations have been discussed.…”

Section: Documented Examples Of Synergism and Antagonismmentioning

confidence: 99%

Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2

2019

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Section: Documented Examples Of Synergism and Antagonismmentioning

confidence: 99%

Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2

2019

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“…For example, some studies have suggested that meaningful synergistic and therapeutic effects of herbal formulations were unlikely due to the low/extremely low levels of active components existed in the herbs (Williamson, 2001 ; Danz et al, 2002 ). This has led to skepticism that herbal therapies are merely placebo effects (Tausk, 1998 ). In contrast, numerous studies have demonstrated that herbal extracts as a whole and/or multiple herbs in complex formulations offer better efficacies than equivalent doses of individual active ingredients and/or herbs when used alone, highlighting the significance of synergistic action in herbal therapies (Leonard et al, 2002 ; Scholey and Kennedy, 2002 ; Zhang et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research

et al. 2016

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Traditional Chinese medicine (TCM) is an important part of primary health care in Asian countries that has utilized complex herbal formulations (consisting 2 or more medicinal herbs) for treating diseases over thousands of years. There seems to be a general assumption that the synergistic therapeutic effects of Chinese herbal medicine (CHM) derive from the complex interactions between the multiple bioactive components within the herbs and/or herbal formulations. However, evidence to support these synergistic effects remains weak and controversial due to several reasons, including the very complex nature of CHM, misconceptions about synergy and methodological challenges to study design. In this review, we clarify the definition of synergy, identify common errors in synergy research and describe current methodological approaches to test for synergistic interaction. We discuss the strengths and weaknesses of these models in the context of CHM and summarize the current status of synergy research in CHM. Despite the availability of some scientific data to support the synergistic effects of multi-herbal and/or herb-drug combinations, the level of evidence remains low, and the clinical relevancy of most of these findings is undetermined. There remain significant challenges in the development of suitable methods for synergistic studies of complex herbal combinations.

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“…Biofeedback training is a therapeutic technique in which patients are trained to consciously alter the autonomic response, in an effort to establish a new habit pattern and influence immunoreactivity to positively affect symptom severity (92, 93). Integrative body-mind training (IBMT) incorporates aspects of mindfulness and meditation and is accompanied by physiological changes, including oxygen consumption, heart rate, skin conductance/resistance, and respiratory rate.…”

Section: Resultsmentioning

confidence: 99%

Psychoneuroimmunology of Psychological Stress and Atopic Dermatitis: Pathophysiologic and Therapeutic Updates

Suárez¹,

Feramisco²,

Koo³

et al. 2012

Acta Derm Venerol

197

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Atopic dermatitis is a chronic inflammatory skin disease characterized by impaired epidermal barrier function, inflammatory infiltration, extensive pruritus and a clinical course defined by symptomatic flares and remissions. The mechanisms of disease exacerbation are still poorly understood. Clinical occurrence of atopic dermatitis is often associated with psychological stress. In response to stress, upregulation of neuropeptide mediators in the brain, endocrine organs, and peripheral nervous system directly affect immune and resident cells in the skin. Lesional and non-lesional skin of patients with atopic dermatitis demonstrates increased mast cells and mast cell-nerve fiber contacts. In the setting of stress, sensory nerves release neuromediators that regulate inflammatory and immune responses, as well as barrier function. Progress towards elucidating these neuroimmune connections will refine our understanding of how emotional stress influences atopic dermatitis. Moreover, psychopharmacologic agents that modulate neuronal receptors or the amplification circuits of inflammation are attractive options for the treatment of not only atopic dermatitis, but also other stress-mediated inflammatory skin diseases.

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Alternative Medicine

Cited by 23 publications

References 35 publications

Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2

Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2

Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research

Psychoneuroimmunology of Psychological Stress and Atopic Dermatitis: Pathophysiologic and Therapeutic Updates

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