Alternative pathways for vitamin D metabolism

Slominski, Andrzej T.; Tuckey, Robert C.; Jenkinson, Carl; Li, Wei; Jetten, Anton M.

doi:10.1016/b978-0-323-91386-7.00001-5

Cited by 6 publications

(7 citation statements)

References 192 publications

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“…Many metabolites of vitamin D have been discovered over the years [15,23,39,40]some of them useful, others not [23,41]. Vitamin D and its analogs are most frequently used for the treatment of osteoporosis, since as suppressing parathyroid hormone (PTH) agents, they increase calcium absorption and bone mineral density [26,41,42].…”

Section: (Oh)d3 Variesmentioning

confidence: 99%

“…The alternative pathways of vitamin D activation in the skin include the metabolism of vitamin D by the CYP11A1 enzyme [23,24,32,[58][59][60] and the production of many different vitamin D hydroxymetabolites (Figure 1). Hydroxylation of the side chain of vitamin D3 by CYP11A1 generates new vitamin D hydroxyderivatives, such as 20(OH)D3 [61] and 20,23(OH) 2 D3 [62].…”

Section: Vitamin D Metabolism In the Skinmentioning

confidence: 99%

“…Hydroxylation of the side chain of vitamin D3 by CYP11A1 generates new vitamin D hydroxyderivatives, such as 20(OH)D3 [61] and 20,23(OH) 2 D3 [62]. Hydroxylation of these new metabolites of vitamin D3 under the CYP27B1 enzyme generates even more potent vitamin D3 hydroxyderivatives: 1,20(OH) 2 D3 [63] and 1,20,23(OH) 3 D3 as examples [23,62]. As tested on rats and mice, 20(OH)D3 is non-calcemic even at high doses, which is in contrast to 1,25(OH) 2 D3 inducing hypercalcemia and attendant toxicity [64][65][66].…”

Section: Vitamin D Metabolism In the Skinmentioning

confidence: 99%

“…These novel secosteroids are biologically active, similarly to 1,25(OH) 2 D3, yet they have lower toxicity and do not cause the calcemic effect, which makes them safer than 1,25(OH) 2 D3 for pharmacological use [40]. The alternative pathways of vitamin D activation in the skin include the metabolism of vitamin D by the CYP11A1 enzyme [23,24,32,[58][59][60] and the production of many different vitamin D hydroxymetabolites (Figure 1). Hydroxylation of the side chain of vitamin D3 by CYP11A1 generates new vitamin D hydroxyderivatives, such as 20(OH)D3 [61] and 20,23(OH)2D3 [62].…”

Section: Vitamin D Metabolism In the Skinmentioning

confidence: 99%

“…All these vitamin D-regulated biological processes are crucial in aging [18,19]. Many cells, especially skin cells, are capable of producing vitamin D in its active forms with specific biological actions on cells dependent on the target organs, thus making it categorized as a pro-hormone and its active forms such as hormones [1,3,11,12,[20][21][22][23][24].…”

Section: Introduction 1vitamin Dmentioning

confidence: 99%

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Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

Janjetovic,

Slominski

2024

Cosmetics

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Vitamin D is a natural photoproduct that has many beneficial effects on different organs, including skin. Active forms of vitamin D and its derivatives exert biological effects on skin cells, thus maintaining skin homeostasis. In keratinocytes, they inhibit proliferation and stimulate differentiation, have anti-inflammatory properties, act as antioxidants, inhibit DNA damage and stimulate DNA repair after ultraviolet (UV) exposure. In melanocytes, they also inhibit cell proliferation, inhibit apoptosis and act as antioxidants. In fibroblasts, they inhibit cell proliferation, affect fibrotic processes and collagen production, and promote wound healing and regeneration. On the other hand, skin cells have the ability to activate vitamin D directly. These activities, along with the projected topical application of vitamin D derivatives, are promising for skin care and photo protection and can be used in the prevention or possible reversal of skin aging.

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Section: (Oh)d3 Variesmentioning

confidence: 99%

Section: Vitamin D Metabolism In the Skinmentioning

confidence: 99%

Section: Vitamin D Metabolism In the Skinmentioning

confidence: 99%

Section: Vitamin D Metabolism In the Skinmentioning

confidence: 99%

Section: Introduction 1vitamin Dmentioning

confidence: 99%

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Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

Janjetovic,

Slominski

2024

Cosmetics

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A review of current trends of vitamin identification and quantification by chromatography from food samples

Avrămia,

Oroian,

Oiţă

2024

Journal of Food Composition and Analysis

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Unraveling the complex interplay between obesity and vitamin D metabolism

Alzohily,

AlMenhali,

Gariballa

et al. 2024

Sci Rep

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Vitamin D deficiency and obesity are a worldwide health issue. Obesity refers to the accumulation of excessive fats in the body which could lead to the development of diseases. Obese people have low vitamin D levels for several reasons including larger volume of distribution, vitamin D tightly bound in fatty tissues, reduced absorption, and diets with low vitamin D. Accurately measuring vitamin D metabolites is challenging. The Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS) method was developed and validated for the analysis of vitamin D metabolites in the serum. Blood samples were collected from 452 subjects which consisted of baseline (vitamin D deficient obese subjects), follow-up (supplemented obese subjects), and healthy volunteers. The vitamin D metabolites were separated adequately by the developed UHPLC-MS/MS method. Moreover, the validation criteria for the method were within an acceptable range. The baseline, follow-up and even healthy volunteers were deficient in 25OHD3 and 25OHD2. The baseline and healthy subjects had comparable concentration of vitamin D2 and D3. However, healthy subjects had a higher concentration of 25OHD and its epimer compared to the baseline subjects. The vitamin D3 was increased significantly in the follow- up subjects; therefore, the 25OHD3 was increased significantly compared to the baseline as well; however, the increase was insufficient to achieve the optimal range. The UHPLC-MS/MS method test was applied successfully on estimation of vitamin D metabolites in subjects. This study indicates the significance of taking into account the metabolic and storage effects when evaluating the vitamin D status in obese subjects.

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Alternative pathways for vitamin D metabolism

Cited by 6 publications

References 192 publications

Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

A review of current trends of vitamin identification and quantification by chromatography from food samples

Unraveling the complex interplay between obesity and vitamin D metabolism

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