Aluminum induced intestinal dysfunction via mechanical, immune, chemical and biological barriers

Hao, Wudi; Hao, Chenyu; Wu, Chi‐Rei; Xu, Yuqing; Jin, Cuihong

doi:10.1016/j.chemosphere.2021.132556

Cited by 43 publications

(34 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanical barrier is an intact intestinal mucosal epithelial structure closely connected to each other, which consists of a mucosal layer, intestinal epithelial cells, intercellular tight junctions, and submucosal lamina propria, and the intact intestinal mucosal epithelial cells and tight junctions between epithelial cells are the structural basis of the mechanical barrier [ 33 ]. Gastric acid, bile, various digestive enzymes, lysozyme, digestive juices, and antibacterial substances produced by parasitic bacteria in the intestinal lumen constitute the chemical barrier of the intestinal tract [ 34 ]. Stomach acid can destroy bacteria entering the gastrointestinal tract and inhibit bacterial adhesion and colonization of the gastrointestinal epithelium; lysozyme can destroy the cell wall of bacteria and cause bacterial lysis; digestive juices secreted by the intestine can dilute toxins and flush the intestinal lumen, making it difficult for potentially pathogenic bacteria to adhere to the intestinal epithelium [ 35 , 36 ].…”

Section: Gut Microbiota and Intestinal Barriermentioning

confidence: 99%

“…The gut microbiota and the gut barrier interact with each other. Intestinal cells regulate the composition of the gut microbiota by secreting antimicrobial peptides, and conversely, the gut microbiota can also affect the growth process of intestinal epithelial cells [ 34 ]. In mice, depletion of the gut microbiota compromises the intestinal epithelium, leading to altered patterns of microvillus formation and reduced cell renewal [ 44 ].…”

Section: Gut Microbiota and Intestinal Barriermentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle

Jin

2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Skeletal muscle is one of the largest organs in the body and is essential for maintaining quality of life. Loss of skeletal muscle mass and function can lead to a range of adverse consequences. The gut microbiota can interact with skeletal muscle by regulating a variety of processes that affect host physiology, including inflammatory immunity, protein anabolism, energy, lipids, neuromuscular connectivity, oxidative stress, mitochondrial function, and endocrine and insulin resistance. It is proposed that the gut microbiota plays a role in the direction of skeletal muscle mass and work. Even though the notion of the gut microbiota–muscle axis (gut–muscle axis) has been postulated, its causal link is still unknown. The impact of the gut microbiota on skeletal muscle function and quality is described in detail in this review.

show abstract

Section: Gut Microbiota and Intestinal Barriermentioning

confidence: 99%

Section: Gut Microbiota and Intestinal Barriermentioning

confidence: 99%

Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle

Jin

2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Intestinal chemical barrier plays an important role in resisting and killing pathogenic bacteria. Various mucins of intestinal chemical barrier can protect intestinal epithelia cells from pathogen invasion ( 62 ). Resveratrol has been found that it well orchestrates the intestinal chemical barrier.…”

Section: Resveratrol and Intestinal Barriermentioning

confidence: 99%

Resveratrol in Intestinal Health and Disease: Focusing on Intestinal Barrier

Wang

Hong

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

The integrity of intestinal barrier determines intestinal homeostasis, which could be affected by various factors, like physical, chemical, and biological stimuli. Therefore, it is of considerable interest and importance to maintain intestinal barrier function. Fortunately, many plant polyphenols, including resveratrol, could affect the health of intestinal barrier. Resveratrol has many biological functions, such as antioxidant, anti-inflammation, anti-tumor, and anti-cardiovascular diseases. Accumulating studies have shown that resveratrol affects intestinal tight junction, microbial composition, and inflammation. In this review, we summarize the effects of resveratrol on intestinal barriers as well as the potential mechanisms (e.g., inhibiting the growth of pathogenic bacteria and fungi, regulating the expression of tight junction proteins, and increasing anti-inflammatory T cells while reducing pro-inflammatory T cells), and highlight the applications of resveratrol in ameliorating various intestinal diseases.

show abstract

“…Toxicity of TCMs is caused not only by toxic medicinal compounds, but also by pollutants such as pesticides, herbicides and heavy metals, which can adversely affect the intestines through the human body ( Feng et al., 2021 ). For example, aluminum accumulated in plants can promote the apoptosis of intestinal epithelial cells, destroy the structure of tight junction proteins, increase intestinal permeability;induce the activation of immune cells to secrete inflammatory factors and trigger immune response;regulate intestinal composition and enzyme activity; induce the imbalance of intestinal flora, inhibit the growth of beneficial bacteria, promote the proliferation of harmful bacteria, and then damage the four barrier of intestinal mucosa in an all-round way ( Hao et al., 2022 ). The environment is closely related to human health.…”

Section: The Reparative Effect Of Tcm On the Intestinal Mucosal Barriermentioning

confidence: 99%

Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier

Che

Luo

Shi

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The effect of a drug on the intestinal flora and the intestinal barrier is an important evaluation index for drug safety and efficacy. Chemical synthetic drugs are widely used due to their advantages of fast efficacy and low doses, but they are prone to cause drug resistance and inhibit proton pumps, which may harm intestinal health. Traditional Chinese medicine (TCM) has been applied clinically for thousands of years, and how TCMs regulate intestinal health to achieve their effects of disease treatment has become a hot research topic that needs to be resolved. This paper reviews the recent research on the effects of TCMs on intestinal microorganisms and the intestinal mucosal barrier after entering the intestine, discusses the interaction mechanisms between TCMs and intestinal flora, and details the repair effect of TCMs on the intestinal mucosal barrier to provide a reference for the development, utilization, and modernization of TCM.

show abstract

Aluminum induced intestinal dysfunction via mechanical, immune, chemical and biological barriers

Cited by 43 publications

References 62 publications

Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle

Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle

Resveratrol in Intestinal Health and Disease: Focusing on Intestinal Barrier

Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier

Contact Info

Product

Resources

About