Aluminum toxicity. Hematological effects

Mahieu, Stella; Contini, María del Carmen; González, Marcela; Millen, Néstor; Elı́as, Marı́a Mónica

doi:10.1016/s0378-4274(99)00184-8

Cited by 67 publications

(46 citation statements)

References 18 publications

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“…Simultaneous treatment of the animals with Allium cepa and aluminum chloride resulted in significant increase in PCV when compared with control, while there was no significant different in RBC and Hb, (Table 1). The reduction in red blood cells count, hemoglobin concentration and packed cell volume in animals treated with aluminum chloride observed in this study is in agreement with previous studies (Mahieu et al, 2000;Kalaiselvi et al, 2015). They reported that reduction in hemoglobin concentration and red blood cells count as a result of exposure to aluminum are a reflection of disrupt red blood cell synthesis.…”

Section: Results and Discusionsupporting

confidence: 94%

“…Diseased or damaged kidneys don't produce sufficient erythropoietin which stimulates bone marrow to produce red blood cells (Winearls et al, 1986). Hematotoxic effect of aluminum has been observed to occur with renal damage manifested with uremia (Mahieu et al, 2000). In the present study serum urea was studied and it was found that aluminum exposure significantly increased serum urea (Figure 2).…”

Section: Ige Sf; Aiyeola Amentioning

confidence: 53%

“…Aluminum is a known environmental toxicant that can cause neurological diseases (Yousef, 2004), reproductive dysfunctions such as, damage of the ovarian structure, ovulation inhibition and testicular dysfunction (Wang et al, 2012;Fu et al, 2014;Ighodaro et al, 2012). It is also known to induce anemia (Mahieu et al, 2000). Reduction in erythropoietin synthesis and secretion, and inhibition of intestinal absorption of iron has been proposed as mechanisms of aluminum-induced anemia (Kalaiselvi et al, 2015) with increase hemolysis and reduce heme and globulin syntheses reported due to aluminum toxicity.…”

mentioning

confidence: 99%

“…Reduction in erythropoietin synthesis and secretion, and inhibition of intestinal absorption of iron has been proposed as mechanisms of aluminum-induced anemia (Kalaiselvi et al, 2015) with increase hemolysis and reduce heme and globulin syntheses reported due to aluminum toxicity. Uremia is usually seen with aluminum-hematotoxicity (Mahieu et al, 2000). Likewise, cardiovascular diseases, cognitive impairment and reduction in quality of life are associated with anemia in kidney diseases (Wang et al, 2012).…”

mentioning

confidence: 99%

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Effect of aqueous <i>Allium cepa</i> extract from red onion on aluminum chloride- induced anemia in female rats

Ige¹,

Aiyeola²

2018

Journal of Applied Sciences and Environmental Management

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This study examined the protective effect of Allium cepa extract from red onion on aluminuminduced anemia in female wistar rats. Twenty-four animals (six rats per group) were used for this study. They were divided into four groups: group one served as control, group two animals were treated with 100mg/kg BW of aluminum chloride and served as Aluminum chloride (AlCl3) group, group three, Allium cepa alone group were treated with 1mL/100g BW of Allium cepa while group four was simultaneously treated with 1mL/100g BW of Allium cepa and 100mg/kg BW AlCl3. Treatments lasted for 4 weeks. Red blood cells (RBC), packed cell volume (PCV), Hemoglobin concentration (Hb) were measured from blood sample collected from each rat. Serum urea, serum and kidney malondialdehyde (index of lipid peroxidation) and kidney catalase and superoxide dismutase (SOD) activities were measured spectrophotometrically. Significant decrease in RBC, PCV, Hb, catalase, SOD and significant increase in serum urea and malondialdehyde were observed in aluminum treated animals when compared with control. Animals treated with Allium cepa alone had significant increase in PCV, Hb, SOD and significant decrease in malondialdehyde and serum urea while there was no significant different in RBC and catalase when compared with control. Simultaneous treatment of the animals with Allium cepa and aluminum chloride resulted in significant increase in PCV while there was no significant different in RBC, Hb, catalase, malondialdehyde when compared with control.This study reveals that Allium cepa extract treatment ameliorate aluminum-induced anemia through antioxidant system.

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Section: Results and Discusionsupporting

confidence: 94%

Section: Ige Sf; Aiyeola Amentioning

confidence: 53%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Effect of aqueous <i>Allium cepa</i> extract from red onion on aluminum chloride- induced anemia in female rats

Ige¹,

Aiyeola²

2018

Journal of Applied Sciences and Environmental Management

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“…Osmotic fragility test is used to study structural disorders (Mahieu et al, 2000) and rigidity of the RBC membrane (Jokinen et al, 2004), and has been modified due to changes in the structure and greater rigidity, which lead to hemolysis. The interaction of certain chemicals with membrane component could stimulate changes in lipid distribution (Oteiza, 1994).…”

Section: Discussionmentioning

confidence: 99%

Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

Taib

Budin

Ain

et al. 2009

J. Zhejiang Univ. Sci. B

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Litsea elliptica Blume leaves have been traditionally used as medicinal herbs because of its antimutagenicity, chemopreventative and insecticidal properties. In this study, the toxic effects of L. elliptica essential oil against Sprague-Dawley rat's red blood cells (RBCs) were evaluated. L. elliptica essential oil was given by oral gavage 5 times per week for 3 treated groups in the doses of 125, 250, and 500 mg/(kg body weight), respectively, and the control group received distilled water. Full blood count, RBC osmotic fragility, RBC morphological changes, and RBC membrane lipid were analyzed 28 d after the treatment. Although L. elliptica essential oil administration had significantly different effects on hemoglobin (Hb), mean cell hemoglobin concentration (MCHC), mean cell volume (MCV), and mean cell hemoglobin (MCH) in the experimental groups as compared to the control group (P<0.05), the values were still within the normal range. L. elliptica induced morphological changes of RBC into the form of echinocyte. The percentage of echinocyte increased significantly among the treated groups in a dose-response manner (P<0.001). The concentrations of RBC membrane phospholipids and cholesterol of all treated groups were significantly lower than those of control group (P<0.001). However, the RBC membrane osmotic fragility and total proteins of RBC membrane findings did not differ significantly between control and treated groups (P>0.05). It is concluded that structural changes in the RBC membrane due to L. elliptica essential oil administration did not cause severe membrane damage.

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