Abstract:Background
The structure of alveoli is critical for normal lung function and when maintenance of the underlying extracellular matrix (ECM) that forms these delicate structures fails, patients may develop emphysema or lung fibrosis via pathological processes that are not fully understood. The alveolar walls are lined by alveolar epithelial cells (AEC), these cells have so far been implicated in pathological remodeling through signaling that alters the activity of mesenchymal and immune cells. We set out to exa… Show more
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