Alveolar ridge augmentation using anodized implants coated with Escherichia coli–derived recombinant human bone morphogenetic protein 2

Huh, Jung-Bo; Park, Chan Kyung; Kim, Se Eun; Shim, Kyung Mi; Choi, Kyung Hee; Kim, Sun Jong; Shim, June Sung; Shin, Sang Wan

doi:10.1016/j.tripleo.2010.09.063

Cited by 21 publications

(27 citation statements)

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“…The 30 studies used five different animal species, which in all cases were unimpaired and systemically healthy. Dog (16) and pig (9) animal models were most common, and smaller groups include goat and sheep as well as one monkey model. Six studies used local defect models.…”

Section: Study Characteristics and Descriptive Resultsmentioning

confidence: 99%

“…Six studies used local defect models. In five studies, implants were partly placed supracrestally, [15][16][17][18][19] in one a periimplant gap model 11 was created. The remaining 24 studies applied no defect models.…”

Section: Study Characteristics and Descriptive Resultsmentioning

confidence: 99%

“…In proximity to the surface, the collagen/CS coating influenced bone formation positively. Five studies [15][16][17][18][19] investigated supraalveolar defect models. BMP-2 was used as a coating component in three of these studies.…”

Section: Study Characteristics and Descriptive Resultsmentioning

confidence: 99%

“…BMP-2 was used as a coating component in three of these studies. 15,16,19 The reference surface in all cases was anodically oxidized titanium. The test surfaces with a rhBMP-2 surface-coating were on anodically oxidized titanium in all three studies 15,16,19 ; the surface in the Wikesjo study was further defined as being a porous oxide.…”

Section: Study Characteristics and Descriptive Resultsmentioning

confidence: 99%

“…15,16,19 The reference surface in all cases was anodically oxidized titanium. The test surfaces with a rhBMP-2 surface-coating were on anodically oxidized titanium in all three studies 15,16,19 ; the surface in the Wikesjo study was further defined as being a porous oxide. The authors concluded that rhBMP-2 coated anodized implants could stimulate bone formation and increase stability significantly on completely healed alveolar ridges in dogs, while rhBMP-2 on porous oxide implant surfaces induced relevant local bone formation, including vertical augmentation of the alveolar ridge and osseointegration.…”

Section: Study Characteristics and Descriptive Resultsmentioning

confidence: 99%

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A systematic review and meta‐analysis on the influence of biological implant surface coatings on periimplant bone formation

Jenny

Jauernik

Bierbaum

et al. 2016

J Biomedical Materials Res

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This systematic review and meta-analysis evaluated the influence of biological implant surface coatings on periimplant bone formation in comparison to an uncoated titanium reference surface in experimental large animal models. The analysis was structured according to the PRISMA criteriae. Of the1077 studies, 30 studies met the inclusion criteriae. Nineteen studies examined the bone implant contact (BIC) and were included in the meta-analysis. Overall, the mean increase in BIC for the test surfaces compared to the reference surfaces was 3.7 percentage points (pp) (95% CI -3.9-11.2, p = 0.339). Analyzing the increase in BIC for specific coated surfaces in comparison to uncoated reference surfaces, inorganic surface coatings showed a significant mean increase in BIC of 14.7 pp (95% CI 10.6-18.9, p < 0.01), extracellular matrix (ECM) surface coatings showed an increase of 10.0 pp (95% CI 4.4-15.6, p < 0.001), and peptide coatings showed a statistical trend with 7.1 pp BIC increase (95% CI -0.8-15.0, p = 0.08). In this review, no statistically significant difference could be found for growth factor surface coatings (observed difference -3.3 pp, 95% CI -16.5-9.9, p = 0.6). All analyses are exploratory in nature. The results show a statistically significant effect of inorganic and ECM coatings on periimplant bone formation. Abstract: This systematic review and meta-analysis evaluated the influence of biological implant surface coatings on periimplant bone formation in comparison to an uncoated titanium reference surface in experimental large animal models. The analysis was structured according to the PRISMA criteriae. Of the1077 studies, 30 studies met the inclusion criteriae. Nineteen studies examined the bone implant contact (BIC) and were included in the meta-analysis. Overall, the mean increase in BIC for the test surfaces compared to the reference surfaces was 3.7 percentage points (pp) (95% CI 23.9-11.2, p 5 0.339). Analyzing the increase in BIC for specific coated surfaces in comparison to uncoated reference surfaces, inorganic surface coatings showed a significant mean increase in BIC of 14.7 pp (95% CI 10.6-18.9, p < 0.01), extracellular matrix (ECM) surface coatings showed an increase of 10.0 pp (95% CI 4.4-15.6, p < 0.001), and peptide coatings showed a statistical trend with 7.1 pp BIC increase (95% CI 20.8-15.0, p 5 0.08). In this review, no statistically significant difference could be found for growth factor surface coatings (observed difference 23.3 pp, 95% CI 216.5-9.9, p 5 0.6). All analyses are exploratory in nature. The results show a statistically significant effect of inorganic and ECM coatings on periimplant bone formation.

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Section: Study Characteristics and Descriptive Resultsmentioning

confidence: 99%