Alveolar ridge dimensional changes following ridge preservation procedure with novel devices: Part 1 – CBCT linear analysis in non‐human primate model

Abstract

AimThis study sought to investigate dimensional changes to the alveolar bone following extraction and application of novel devices used for obturation of socket orifice (socket cap) and space maintenance in sockets with facial dehiscence (socket cage).Material and methodsSix Macaca fascicularis had six teeth each removed according to the following intervention groups (groups A–C intact alveolar bone; D–E facial dehiscence): negative control (A); socket obturated with cap (B); filled with anorganic bovine bone mineral (ABBM) + socket cap (C); dehiscence negative control (D); socket cap + socket cage (E); ABBM + socket cap + socket cage (F). Serial CBCT scans at preoperatively, 6 and 12 weeks following intervention were compared to quantify linear alveolar bone alterations.ResultsWithout therapeutic intervention, intact sockets exhibited significant reduction in width at the crestal 2 mm of the ridge crest within 6 weeks. Compared with the negative control sites which lost up to 52% of crestal bone width, sites treated with socket cap + ABBM lost at most 4% of bone width at the crestal 2 mm. Similar results were seen in the dehiscence groups, with the combination of socket cap + socket cage + ABBM maintaining the greatest socket width and height dimensions.ConclusionsResults from the current non‐human primate study suggest that the socket cap and socket cage devices, when used in conjunction with xenograft proved effective in minimizing post‐extraction socket width loss and height seen in both intact sockets and sockets with facial dehiscence defects.

Collagen Sponge Functionalized with Chimeric Anti-BMP-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model

“…The anesthesia was maintained by IV Propofol (2.5 mg/kg) per 30~45 min. Local anesthesia was achieved by intramucosal injection of lidocaine with 1 : 100,000 epinephrine (Astra Zeneca, London, England) [21, 22]. Hair over the right mandibular region was shaved.…”

An open randomized controlled clinical trial to evaluate ridge preservation and repair using SocketKAP™ and SocketKAGE™: part 2 – three‐dimensional alveolar bone volumetric analysis of CBCT imaging

“…; Min et al. ). Importantly, multiple published systematic reviews of human randomized clinical trials validate these prior animal studies, documenting a mean horizontal reduction of 3.8 mm and a mean vertical reduction of 1.24 mm within 6 months of tooth extraction.…”

Alveolar ridge dimensional changes following ridge preservation procedure with novel devices: part 3 – histological analysis in non‐human primate model

“…Our study of alveolar bone resorption in non‐human primate is the first using this model (Min et al. ; Omran et al. ).…”

“…A recent series of studies in non‐human primate model (Min et al. ; Omran et al. ) have provided important insights into post‐extraction volumetric changes, as well as the effects of novel ridge preservation and augmentation devices on these morphometric changes.…”

“…) and non‐human primate animal model (Min et al. ; Omran et al. ), as well as clinical studies (Abdelhamid et al.…”