Alzheimer's disease: Preliminary study of spatial distribution at birth place

Jean, Hugo; Emard, Jean-François; Thouez, Jean-Pierre; Houde, Louis; Robitaille, Yves; Mathieu, Jean; Boily, C.; Daoud, Nicolas; Beaudry, Michel; Cholette, A.; Bouchard, Rémi W.; Veilleux, Francine; Gauvreau, D.

doi:10.1016/0277-9536(95)00185-9

Cited by 22 publications

(17 citation statements)

References 14 publications

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“…The studies ranged in size from 321 28 to the entire population of the USA. 29 Methodologies included multiple-phase population surveys (n ¼ 13 19,21,30-50 ), one-phase surveys (n ¼ 10 22,23,28,51-59 ), using death certificate data (n ¼ 8 20, 29,49,[60][61][62][63][64][65]88 ) and case registers (n ¼ 3 [66][67][68][69][70][71][72] ). Eight studies included a longitudinal design allowing dementia incidence to be ascertained.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies included a clinical assessment of participants. 19,21,30,[32][33][34][35][36][37][38][39][42][43][44][45][46][47][48][49]50,58,66,67,71 The papers included in the review were divided into groups reflecting the scale of comparison. Each group will be considered, in turn, comparing rates between countries or nationwide surveys, rural and urban areas, regions, towns or cities and smaller areas.…”

Section: Resultsmentioning

confidence: 99%

“…20,22 The latest report from the 10/66 Dementia Research Group was excluded because it did not give sufficient data for inclusion despite reporting a slightly later stage of the study. 57 There was evidence of an association between rurality and prevalence of AD 37,42,47,67 (OR ¼ 1.50, 90% CI 1.33-1.69) but much less so for vascular dementia 30,37,47 Only one prevalence study classified participants according to more than one set of diagnostic criteria. 23 Altering the criteria used had a substantial effect on the association between non-specific dementia and rurality: using DSM-IV criteria (OR ¼ 0.91, 90% CI 0.57-1.45), using 10/66 consensus criteria (OR ¼ 1.14, 90% CI 0.80-1.61) and excluding the four comparisons reported in this study (OR ¼ 1.32, 90% CI 0.73-2.39).…”

Section: Odds Ratiomentioning

confidence: 99%

See 2 more Smart Citations

Geographical variation in dementia: systematic review with meta-analysis

Russ

Batty

Hearnshaw

et al. 2012

International Journal of Epidemiology

156

140

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Odds Ratiomentioning

confidence: 99%

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Geographical variation in dementia: systematic review with meta-analysis

Russ

Batty

Hearnshaw

et al. 2012

International Journal of Epidemiology

156

140

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“…Epidemiological studies have reported a higher prevalence of AD in rural areas than in urban settings. Over the past decades, pesticides have been used to increase the productivity and the specialization of cultures in rural areas9. Evidence from in-vitro models and animal studies suggests that long-term/low-dose pesticide exposure may lead to the neuronal loss in specific brain regions, resulting in subsequent cognitive impairment, decreased memory and attention, and loss of motor function1011.…”

mentioning

confidence: 99%

Pesticide exposure and risk of Alzheimer’s disease: a systematic review and meta-analysis

Yan

Zhang

Liu

et al. 2016

Sci Rep

153

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Evidence suggests that lifelong cumulative exposure to pesticides may generate lasting toxic effects on the central nervous system and contribute to the development of Alzheimer’s disease (AD). A number of reports indicate a potential association between long-term/low-dose pesticide exposure and AD, but the results are inconsistent. Therefore, we conducted a meta-analysis to clarify this association. Relevant studies were identified according to inclusion criteria. Summary odds ratios (ORs) were calculated using fixed-effects models. A total of seven studies were included in our meta-analysis. A positive association was observed between pesticide exposure and AD (OR = 1.34; 95% confidence interval [CI] = 1.08, 1.67; n = 7). The summary ORs with 95% CIs from the crude and adjusted effect size studies were 1.14 (95% CI = 0.94, 1.38; n = 7) and 1.37 (95% CI = 1.09, 1.71; n = 5), respectively. The sensitivity analyses of the present meta-analysis did not substantially modify the association between pesticide exposure and AD. Subgroup analyses revealed that high-quality studies tended to show significant relationships. The present meta-analysis suggested a positive association between pesticide exposure and AD, confirming the hypothesis that pesticide exposure is a risk factor for AD. Further high-quality cohort and case-control studies are required to validate a causal relationship.

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“…Another incidental finding was that suburban residency may be more protective from developing AD than urban residency. Although there were evidences that AD are associated with some environmental agents 41 , such as heavy metals or pesticides, the risk of developing AD related to the levels of urbanization was still not identified 42 , 43 .…”

Section: Discussionmentioning

confidence: 99%

Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study

Chu

Liang

Yeh

et al. 2020

Sci Rep

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Previous studies have shown that central auditory dysfunction without severe peripheral hearing loss was associated with higher incidences of cognitive decline and Alzheimer's dementia 11,12. Both hearing loss and central auditory dysfunction are associated with higher risk of developing dementia 5-10 years later 13. Uhlmann et al. 14 demonstrated an association of hearing impairment and Alzheimer's dementia. There may be a pathophysiological interplay of hearing impairment and neurodegeneration. Although the prevalence of tinnitus is not exactly related to the prevalence of hearing loss, chronic tinnitus is usually accompanied by a hearing impairment 4. Previous research revealed that chronic tinnitus was related to the anatomical brain abnormalities, including cortical grey matter reduction and reduced white matter integrity 15. In previous decades, structural and functional brain research showed the correlation between annoying tinnitus and various forms of cognitive dysfunction, especially executive control of attention and working memory 16. Such studies suggest that changes in hearing, olfaction may antecede the beginning of cognitive impairments and dementia as the strong risk factors of AD dementia 17,18. On the other hand, adequate research shows that specific sensory changes may be early biomarkers for AD 13. Previous studies have not used population-based cohort study to evaluate the relationship between tinnitus and subsequence risk of AD and PD. We applied nationwide data from the National Health Insurance (NHI) system to operate a retrospective population-based cohort study in Taiwan. This reliable data has been used for various studies, including tinnitus and AD/PD 19-21. The hypothesis of this study is that tinnitus might be related with the likelihood of subsequent diagnosis of AD and PD. We aim to determine the possibility of an association between tinnitus and a higher risk of AD and PD development. Methods Data sources. The NHI program, an essential health insurance program instituted in 1995, provided comprehensive medical care coverage to about 99% of the residents in Taiwan, including inpatient, outpatient, emergency, and traditional Chinese medicine services 22. Comprehensive information on medical visits, including diagnostic codes and prescription details according to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) are provided by the NHI Research Database (NHIRD). NHIRD is supervised by the National Health Research Institutes, with confidentiality kept in congruence with the directives of the NHI Bureau, Taiwan. Data used in the current study are from the Longitudinal Health Insurance Database 2005 (LHID2005). LHID2005 data were methodically and randomly retracted from the NHIRD, which contains data on one million people. No significant differences in the average insured payroll-related amount, sex distribution, or age distribution between patients in the LHID2005 and those in the original NHIRD were reported by NHRI 23 .

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Alzheimer's disease: Preliminary study of spatial distribution at birth place

Cited by 22 publications

References 14 publications

Geographical variation in dementia: systematic review with meta-analysis

Geographical variation in dementia: systematic review with meta-analysis

Pesticide exposure and risk of Alzheimer’s disease: a systematic review and meta-analysis

Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study

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