Alzheimer's Disease prevalence, costs, and prevention for military personnel and veterans

Sibener, Leslie; Ibrahim, Zaganjor; Snyder, Heather M.; Bain, Lisa J.; Egge, Robert; Carrillo, María C.

doi:10.1016/j.jalz.2014.04.011

Cited by 61 publications

(39 citation statements)

References 44 publications

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“…Although there is no published document on AD and other dementias YLD rates in these countries, several important hazardous behaviors may be positively related to this downward trend in YLD rates. Lack of adequate knowledge about dementia, widespread poverty, relatively low economic growth rate, low level of literacy, occurrence of war in some of these countries (e.g., Iraq, Lebanon, Afghanistan, Syria, Yemen, Palestine, and Libya), inadequate mental healthcare system, insufficient length of treatment, and decrease in life expectancy can be regarded as some of these related factors [19,[28][29][30][31][32][33][34].…”

Section: Resultsmentioning

confidence: 99%

Years Lived with Disability due to Alzheimer’s Disease and Other Dementias in Asian and North African Countries: A Trend Analysis

Amini

Zayeri

Moghaddam

2019

JEGH

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In Asia, which has a rapidly aging population, dementia is the most prominent disease. This article presents an application of Latent Growth Mixture Model (LGMM) to identify classes of individual Alzheimer’s Disease (AD) and other dementias Years Lived with Disability (YLD) rates for Asian and North African countries based on the unobserved heterogeneity. The AD and other dementias YLD data for both sexes and age-standardized groups reported by the Global Burden of Disease (GBD) Study database during 1990–2015 for 55 Asian and North African countries were analyzed via LGMM. Findings of LGMMs identified four classes of YLD trajectories. Among the specified classes, a class was related to a single country (Turkey) with the highest starting point in 1990 (intercept of 218.52 per 100,000) and upward trend. Another class with increasing trend (a slope of 2.66 per 100,000) consisted of India, China, Singapore, Japan, and Egypt. Other countries in Asia and North Africa (Classes 3 and 4) had a downward trend of YLD rates. The upward trend for some parts of Asia and North Africa might be attributed to appropriate therapeutic strategies, higher levels of awareness, related medical cares, and increase in life expectancy in these countries.

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Section: Resultsmentioning

confidence: 99%

Years Lived with Disability due to Alzheimer’s Disease and Other Dementias in Asian and North African Countries: A Trend Analysis

Amini

Zayeri

Moghaddam

2019

JEGH

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“…For example, if the underlying aetiology is unrelated to PTSD, treatment of PTSD will not be effective in preventing dementia (Childress et al 2013). Several authors have identified the need for further longitudinal research on the effect of neurological changes from PTSD on the subsequent development of dementia (Childress et al 2013;Doyle et al 2014;Qureshi et al 2010;Sibener et al 2014;Sorrell & Durham 2011;Weiner et al 2014).…”

Section: Theme 3: Implications For Health-care Providers and Treatmenmentioning

confidence: 99%

Post‐traumatic stress disorder and dementia in veterans: A scoping literature review

Ritchie

Cramm

Aiken

et al. 2019

Int J Mental Health Nurs

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Emerging research has found an association between post‐traumatic stress disorder (PTSD) and dementia in veterans, yet little is known about the nature of this association and how it is conceptualized in the literature. The purpose of this scoping review is to understand how the relationship between PTSD and dementia in veterans is recognized and described in the peer‐reviewed literature. A scoping review was conducted using Arksey and O'Malley's (International Journal of Social Research Methodology, 8, 19, 2005) framework. Articles are included if participants were veterans with a focus on PTSD and dementia. A total of six databases (CINAHL, MEDLINE, EMBASE, PsycINFO, HealthSTAR, and PubMed) were searched along with the reference lists of eligible sources in September 2018. Thematic analysis was used to summarize the data. Thirty‐six studies were included in this review. Three main themes emerged from the literature: (i) symptomatic expression of PTSD and dementia; (ii) aetiology underlying the relationship between PTSD and dementia; and (iii) implications of PTSD and dementia on healthcare providers, treatment, and resources. This study highlights the ongoing need to understand mechanisms underlying the association between PTSD and dementia, the need for definition of PTSD symptoms, and to sensitize healthcare providers to the presence of PTSD when caring for veterans with dementia.

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“…Among them, 70% of dementia patients will become AD (Reitz & Mayeux, 2014). Notably, large affected population and long-term disability pose a huge challenge to public health (Sibener et al, 2014). Therefore, people have attached greatly importance to early diagnosis and treatment of AD.…”

Section: Introductionmentioning

confidence: 99%

Whole Blood mRNA Expression Pattern Differentiates AD Patients and Healthy Controls Through Bioinformatics Analysis

Zhu¹,

Wang²

2019

JBLS

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Background: Gene chip has a wide range of applications in screening disease markers.Methods: GSE63063 dataset including 238 healthy controls and 285 patients with Alzheimer’s disease (AD) was downloaded to investigate the whole blood mRNA expression pattern. Lumi and LIMMA packages of R software were used to screening differential-expressed genes (DEGs). We functionally annotate DEGs through DAVID database. Then STRING database and Cytoscape software were used to construct protein-protein interaction models for hub genes.Results: Our results indicated that 51 DEGs altered in AD patients compared with healthy controls. These DEGs was associated with transcription (BP), RNA binding (MF) and ribosome (CC) terms and the ribosome signaling pathway. In addition, Ribosomal protein S17 (RPS17) was identified as the top 1 in hub genes using maximal clique centrality. RPS17 mutations reduced erythrocyte production and impaired brain development. Finally, the expression levels of the three genes (NDUFA1, RPL36AL, and NDUFS5) showed a good predictive effect.Conclusion: In conclusion, we explored the expression of genes in the AD blood and NDUFA1 may be a potential biomarker for predicting AD.

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Alzheimer's Disease prevalence, costs, and prevention for military personnel and veterans

Cited by 61 publications

References 44 publications

Years Lived with Disability due to Alzheimer’s Disease and Other Dementias in Asian and North African Countries: A Trend Analysis

Years Lived with Disability due to Alzheimer’s Disease and Other Dementias in Asian and North African Countries: A Trend Analysis

Post‐traumatic stress disorder and dementia in veterans: A scoping literature review

Whole Blood mRNA Expression Pattern Differentiates AD Patients and Healthy Controls Through Bioinformatics Analysis

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