Amarogentin has protective effects against sepsis-induced brain injury via modulating the AMPK/SIRT1/NF-κB pathway

Song, Bihui; Zhou, Wenhao

doi:10.1016/j.brainresbull.2022.08.018

Cited by 11 publications

(3 citation statements)

References 40 publications

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“…Accordingly, regulation of TNF levels is considered to be important in the treatment of various Central Nervous System (CNS)-related diseases [ 31 ]. In addition, alleviation of oxidative phosphorylation was reported to improve neurological functions in mice [ 32 ]. RNA-seq analysis revealed that the Atf4 gene was significantly downregulated, while End1 , Lif and Socs3 genes were significantly upregulated in the TNF signaling pathway in the SLPQ1 group compared with the control group.…”

Section: Resultsmentioning

confidence: 99%

Promoting Effect and Potential Mechanism of Lactobacillus pentosus LPQ1-Produced Active Compounds on the Secretion of 5-Hydroxytryptophan

Zeng

Song

Zhang

et al. 2022

Foods

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5-hydroxytryptophan (5-HTP) is an important substance thought to improve depression. It has been shown that Lactobacillus can promote the secretion of 5-HTP in the body and thus ameliorate depression-like behavior in mice. However, the mechanism by which Lactobacillus promotes the secretion of 5-HTP is unclear. In this study, we investigated the promoting effect and mechanism of Lactobacillus, isolated from Chinese fermented foods, on the secretion of 5-HTP. The results showed that Lactobacillus (L.) pentosus LPQ1 exhibited the strongest 5-HTP secretion-promoting effect ((9.44 ± 0.69)-fold), which was dependent on the mixture of compounds secreted by L. pentosus LPQ1 (termed SLPQ1). In addition, the results of the RNA sequencing (RNA-seq) and quantitative real-time polymerase chain reaction (qRT-PCR) analyses indicated that SLPQ1 alters the TNF and oxidative phosphorylation signaling pathways. Moreover, the SLPQ1 ultrafiltration fraction (>10 kDa) showed a similar 5-HTP promoting effect as SLPQ1. Furthermore, reverse-phase liquid chromatography-tandem mass spectrometry (RPLC-MS/MS) identified 29 compounds of >10 kDa in SLPQ1, including DUF488 domain-containing protein, BspA family leucine-rich repeat surface protein, and 30S ribosomal protein S5, which together accounted for up to 62.51%. This study reports new findings on the mechanism by which L. pentosus LPQ1 promotes 5-HTP production in some cell lines in vitro.

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Section: Resultsmentioning

confidence: 99%

Promoting Effect and Potential Mechanism of Lactobacillus pentosus LPQ1-Produced Active Compounds on the Secretion of 5-Hydroxytryptophan

Zeng

Song

Zhang

et al. 2022

Foods

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“…We observed the expression of mitochondrial antioxidants in NSC-34 cells at different time points after LPS intervention, and found that the changes were most significant at 24 h. Similarly, LPS-induced oxidative stress in NSC-34 cells for 24 h has also been widely adopted by other studies. 29,30 Therefore, samples were collected at 24 h after LPS intervention in the subsequent experiments. Lentiviral vectors are used in biological experiments, which are effective tools for transferring and integrating transgenes of interest into mammalian cells.…”

Section: Fndc5 Can Significantly Inhibit Caspase3 and Bax Pathwaysmentioning

confidence: 99%

FNDC5/Irisin protects neurons through Caspase3 and Bax pathways

Zhang,

Zhao

et al. 2024

Cell Biochemistry & Function

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Irisin is a glycosylated protein formed from the hydrolysis of fibronectin type III domain‐containing protein 5 (FNDC5). Recent studies have demonstrated that FNDC5/Irisin is involved in the regulation of glucose and lipid metabolism, it can inhibit inflammation and have neuroprotective effects. However, the effect and mechanism of FNDC5/Irisin on motor neuron‐like cell lines (NSC‐34) have not been reported. In this study, we used lipopolysaccharide to construct cellular oxidative stress injury models and investigated the potential roles of FNDC5/Irisin on neurons by different cellular and molecular pathways. Taken together, our findings showed that FNDC5/Irisin can protect neurons, and this effect might be associated with Caspase3 and Bax pathways. These results laid the foundation for neuronal protection and clinical translation of FNDC5/Irisin therapy.

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“…The mechanism of action of these compounds was to inhibit the upstream mTOR pathways. Fucoxanthinol, the active form of fucoxanthin metabolite from seaweeds has a neuroprotective activity by preventing inflammation, ROS scavenging effect, and activation of mTOR (Song & Zhou, 2022). Sirolimus can be found in the marine bacterium Streptomyces hygroscopicus (Nguyen et al, 2019).…”

Section: Rivarti Et Almentioning

confidence: 99%

Alzheimer's disease from a diabetic brain: Exploring the molecular process to determine the potential therapy target from marine sources

Rivarti,

Saputri,

Harahap

et al. 2023

Pharm Educ

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Background: The prevalence of Alzheimer’s Disease (AD) among Type 2 Diabetes Mellitus (T2D) patients has reached almost 30%. Despite the rapid development, treatments for patients with T2D have not succeeded in controlling the neurodegenerative processes that occur in these patients' brains, leading to AD pathology. Several studies have demonstrated that marine sources can inhibit several AD pathogenesis pathways in T2D patients. This review aimed to determine the effect of marine species-sourced compounds at the molecular level in inhibiting and preventing the pathogenesis of AD in T2D patients. Method: Combinations of several terms were used to search for peer-reviewed literature published in PubMed, Scopus, and Google Scholar. Result: Marine organisms-sourced compounds inhibited various target signalling pathways between T2D and AD, such as an inhibitor of β-site-amyloid precursor protein cleaving enzyme 1 (BACE1) also known as β-secretase, glycogen synthase kinase-3 beta (GSK3B), insulin degradation enzyme (IDE), the mammalian target of rapamycin (mTOR), nuclear factor kappa-light-chain-enhancer (NF-κb), and nuclear factor erythroid 2-related factor 2 (Nrf2). Conclusion: Marine sources can be considered as a potential therapy to prevent or slow AD progression in T2D patients.

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Amarogentin has protective effects against sepsis-induced brain injury via modulating the AMPK/SIRT1/NF-κB pathway

Cited by 11 publications

References 40 publications

Promoting Effect and Potential Mechanism of Lactobacillus pentosus LPQ1-Produced Active Compounds on the Secretion of 5-Hydroxytryptophan

Promoting Effect and Potential Mechanism of Lactobacillus pentosus LPQ1-Produced Active Compounds on the Secretion of 5-Hydroxytryptophan

FNDC5/Irisin protects neurons through Caspase3 and Bax pathways

Alzheimer's disease from a diabetic brain: Exploring the molecular process to determine the potential therapy target from marine sources

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