Ambient desorption/ionization mass spectrometry for direct solid material analysis

Shrestha, Sarmila Amatya; Cha, Sangwon

doi:10.1016/j.trac.2021.116420

Cited by 10 publications

(5 citation statements)

References 161 publications

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“…Consequently, it has become a powerful tool for directly analyzing various chemicals in complex samples, such as agrochemicals . However, given that each agro-product has a different composition, morphology, hardness, and water content, matrix interference is unavoidable for agrochemical analysis with LTP-MS, leading to selectivity and sensitivity problems . Thus, effective and clear-up technologies of multiple pesticides are the crucial pre-requirements for the LTP-MS analysis method.…”

Section: Introductionmentioning

confidence: 99%

“…12 However, given that each agro-product has a different composition, morphology, hardness, and water content, matrix interference is unavoidable for agrochemical analysis with LTP-MS, leading to selectivity and sensitivity problems. 13 Thus, effective and clear-up technologies of multiple pesticides are the crucial pre-requirements for the LTP-MS analysis method. At present, three methods are frequently developed for sample preparation: liquid−liquid extraction, QuEChERS, and solid-phase extraction.…”

Section: ■ Introductionmentioning

confidence: 99%

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“UV-Driven Self-Cleaning” Magnetic Molecularly Imprinted Absorbents Coupled with LTP-MS and LC-TQ-MS for Rapid High-Throughput Screening and Quantification of Organophosphorus Pesticides in Agro-products

Wang

Zhang

et al. 2023

J. Agric. Food Chem.

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Organophosphorus magnetic molecularly imprinted polymers (OMMIPs) with high adsorption capacities (13.5–83.8 mg g–1) and good applicability were developed for efficient extraction and pre-concentration of multiple organophosphorus pesticides (OPPs) from foodstuffs. The OMMIP-based sample pretreatment coupled with low-temperature plasma ambient ionization mass spectrometry achieved rapid screening for 90 kinds of pesticides at default maximum residue limits of National Standard (GB 2763-2021) in nine types of agro-products. The OMMIP-based liquid chromatography coupled with triple quadrupole mass spectroscopy assay demonstrated rapid magneto-actuated isolation, efficient removal of matrix interference, and reduced signal suppression, resulting in a short detection time (30 min), compliant recoveries (60.1–127.5%), low detection limits (0.0001–0.073 μg g–1), and simultaneous quantification of multi-pesticides. The yolk–shell-structured OMMIPs (Fe3O4@mTiO2@MIPs) demonstrated additional benefits of excellent ultraviolet light-driven catalytic degradation activity toward OPPs, making them eco-friendly for self-cleaning regeneration and reducing laboratory pesticide discharge. This work highlights the potential of OMMIPs for high-throughput and in situ pesticide monitoring in modern large-scale agricultural markets.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

“UV-Driven Self-Cleaning” Magnetic Molecularly Imprinted Absorbents Coupled with LTP-MS and LC-TQ-MS for Rapid High-Throughput Screening and Quantification of Organophosphorus Pesticides in Agro-products

Wang

Zhang

et al. 2023

J. Agric. Food Chem.

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“…Since its emergence, the ambient ionization mass spectrometry (AIMS) 1 technique has received considerable attention among researchers in biomedicine, pharmaceuticals, environmental science, food safety, and chemical reaction monitoring. [2][3][4][5] Ambient ionization operates under an ambient environment and requires minimal or no sample preparation before mass spectrometric analysis, allowing the determination of target analytes in gas, liquid, and solid samples in high-throughput modes. According to the desorption methods, 2,5 ambient ionization can be categorized into three types, namely electrospray, laser, and plasma-based ionization sources.…”

Section: Introductionmentioning

confidence: 99%

Improvement in the performance of focusing plasma desorption ionization by altering its counter electrode

Zheng

Zuo

Xiang

et al. 2023

Rapid Comm Mass Spectrometry

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RationalePlasma‐based ionization sources play a vital role in rapidly analyzing diverse compounds without extensive sample pretreatment. In contrast to other sources, DC voltage‐based ionizations are more advantageous due to their high analytical sensitivity and good tandem with commercially available mass spectrometers without extra power supplies. However, their performance is at the risk of high current DC voltage and helium flow rate, which poses significant challenges to practical operation and increased expense.MethodsIn this work, we propose a novel focusing plasma desorption ionization (FPDI) in which a visible plasma beam is favorably generated between a conducting wire in a polymeric tube and a counter electrode composed of metal mesh and filter paper drilled with holes. A systematic investigation has been conducted on the influences of the geometry of drilled holes in filter paper, applied DC voltage, helium flow rate, and filter paper size. The optimized system is used to analyze various pesticides in fluid foodstuffs.ResultsCompared to metal mesh and conducting paper as the counter electrode for FPDI‐MS, combining metal mesh and filter paper drilled holes improved the analysis sensitivity by a factor of more than five. By applying the developed protocol for determining pesticides in complex matrixes such as orange juice and milk, a limit of detection as low as 1.3–3.0 ng mL−1 could be achieved.ConclusionsA novel FPDI‐MS technique has been developed by combining metal mesh and filter paper drilled with holes as the counter electrode and sample carrier. The corresponding improvement in analysis sensitivity facilitates the future expansion of FPDI‐MS applications into different pesticides and other compounds in complex matrixes.

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“…Ambient ionization mass spectrometry (MS) has gained widespread attention since the introduction of desorption electrospray ionization (DESI) by Cooks and co-workers in 2004, and diverse protocols , have been developed so far. Due to the unique features of operating at atmospheric pressure with little or no sample pretreatment, ambient ionization sources coupled to MS have been applied extensively for the rapid identification and semi-quantification of diverse compounds of interest in biological samples, − foodstuffs, , forensics, environmental matrixes, and chemical reactions. , According to the properties of ambient ionization, , they can be classified into spray-based (e.g., DESI) and plasma-based (e.g., direct analysis in real time (DART)) techniques. The major difference between both categories lies that target analytes with the former are charged via solvents upon high voltage, while the ones with the latter are ionized by the reactive species generated in a plasma plume.…”

Section: Introductionmentioning

confidence: 99%

Focusing Plasma Desorption/Ionization Mass Spectrometry

et al. 2022

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A plasma-based source named focusing plasma desorption/ionization (FPDI) is described, which applies a high direct current voltage between a metal wire inside a polymeric hollow truncated cone and a piece of a one-sided coated conducting paper substrate. The conducting paper acts as both the counter electrode and the sample carrier. Upon the generation of a visible plasma beam, it would directly ionize the samples spotted on the conducting paper substrate or located around the plasma beam. The signal intensity of target analytes in mass spectrometric analysis is dependent highly on whether the conducting paper substrate is grounded or not, the type of conducting paper substrate, the inside diameter of the polymeric hollow truncated cone tip, the metal wire tip-topolymer tip distance, the polymer tip-to-paper substrate distance, the applied voltage, and the helium flow rate. Based on the experimental observation, a plausible mechanism is proposed for the generation of the plasma beam from FPDI. Compared to the available low-temperature plasma, flowing atmospheric-pressure afterglow, and helium plasma ionization sources, FPDI has demonstrated higher sensitivity and better compatibility with commercial mass spectrometers without any extra power supplies. As a proof of concept, FPDI coupled with a mass spectrometer has also been applied for the discrimination of different brands of gasoline and determination of solid tablets and pesticides with limits of detection in the range of 2.2 to 30.7 ng mL −1 .

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Ambient desorption/ionization mass spectrometry for direct solid material analysis

Cited by 10 publications

References 161 publications

“UV-Driven Self-Cleaning” Magnetic Molecularly Imprinted Absorbents Coupled with LTP-MS and LC-TQ-MS for Rapid High-Throughput Screening and Quantification of Organophosphorus Pesticides in Agro-products

“UV-Driven Self-Cleaning” Magnetic Molecularly Imprinted Absorbents Coupled with LTP-MS and LC-TQ-MS for Rapid High-Throughput Screening and Quantification of Organophosphorus Pesticides in Agro-products

Improvement in the performance of focusing plasma desorption ionization by altering its counter electrode

Focusing Plasma Desorption/Ionization Mass Spectrometry

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