Ambient ionization and miniature mass spectrometry system for chemical and biological analysis

Ma, Xiaoxiao; Ouyang, Zheng

doi:10.1016/j.trac.2016.04.009

Cited by 102 publications

(86 citation statements)

References 87 publications

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“…The pursuit of the high throughput drug analysis has led to the coupling of ambient ionization methods to field-portable MS instrumentation [39,40], allowing rapid and flexible screening of controlled substances and other contraband while enjoying the discriminating power of MS analysis. Reported applications demonstrate the utility of specific ambient MS techniques in this arena, allowing the direct analysis of utilized surface swabs [24], trace residues [41], bulk evidence [42], and highly complex sample matrices [26,43].…”

Section: A Review Of the 2009 Census For Publicly Funded Forensicmentioning

confidence: 99%

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Lawton

Traub

Fatigante

et al. 2016

J. Am. Soc. Mass Spectrom.

103

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Abstract. Forensic evidentiary backlogs are indicative of the growing need for costeffective, high-throughput instrumental methods. One such emerging technology that shows high promise in meeting this demand while also allowing on-site forensic investigation is portable mass spectrometric (MS) instrumentation, particularly that which enables the coupling to ambient ionization techniques. While the benefits of rapid, on-site screening of contraband can be anticipated, the inherent legal implications of field-collected data necessitates that the analytical performance of technology employed be commensurate with accepted techniques. To this end, comprehensive analytical validation studies are required before broad incorporation by forensic practitioners can be considered, and are the focus of this work. Pertinent performance characteristics such as throughput, selectivity, accuracy/precision, method robustness, and ruggedness have been investigated. Reliability in the form of false positive/negative response rates is also assessed, examining the effect of variables such as user training and experience level. To provide flexibility toward broad chemical evidence analysis, a suite of rapidly-interchangeable ion sources has been developed and characterized through the analysis of common illicit chemicals and emerging threats like substituted phenethylamines.

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Section: A Review Of the 2009 Census For Publicly Funded Forensicmentioning

confidence: 99%

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Lawton

Traub

Fatigante

et al. 2016

J. Am. Soc. Mass Spectrom.

103

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show abstract

“…The objective is to translate the reactive methodology demonstrated with a commercial benchtop system, to a portable MS platform. Recent reports that couple ambient ionization methods, including PS, with portable mass spectrometers are promising 65 66 67 68 69 . In this respect, portable ion trap technology is often preferred as tandem analysis can be performed in time, without increase in instrument footprint.…”

Section: Discussionmentioning

confidence: 99%

Direct Analysis and Quantification of Metaldehyde in Water using Reactive Paper Spray Mass Spectrometry

Maher

Jjunju

Damon

et al. 2016

Sci Rep

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Metaldehyde is extensively used worldwide as a contact and systemic molluscicide for controlling slugs and snails in a wide range of agricultural and horticultural crops. Contamination of surface waters due to run-off, coupled with its moderate solubility in water, has led to increased concentration of the pesticide in the environment. In this study, for the first time, rapid analysis (<~1 minute) of metaldehyde residues in water is demonstrated using paper spray mass spectrometry (PS-MS). The observed precursor molecular ions of metaldehyde were confirmed from tandem mass spectrometry (MS/MS) experiments by studying the fragmentation patterns produced via collision-induced dissociation. The signal intensity ratios of the most abundant MS/MS transitions for metaldehyde (177 → 149 for protonated ion) and atrazine (221 → 179) were found to be linear in the range 0.01 to 5 ng/mL. Metaldehyde residues were detectable in environmental water samples at low concentration (LOD < 0.1 ng/mL using reactive PS-MS), with a relative standard deviation <10% and an R2 value >0.99, without any pre-concentration/separation steps. This result is of particular importance for environmental monitoring and water quality analysis providing a potential means of rapid screening to ensure safe drinking water.

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“…In order to take advantage of advances in portable mass spectrometers, a necessary condition is the ability to sample and ionize neutral analytes with minimal sample preparation as well as simple high‐voltage supply apparatus. Here, we present the first application of the recently developed TENG MS ion source to pharmaceutical forensics using a dry wooden toothpick to sustain electrospray ionization (ESI) .…”

Section: Introductionmentioning

confidence: 99%

Triboelectric nanogenerator (TENG) mass spectrometry of falsified antimalarials

Bernier

Winalski

et al. 2018

Rapid Comm Mass Spectrometry

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RationaleAn epidemic of low‐quality medicines continues to endanger patients worldwide. Detection of such ‘medicines’ requires low cost, ambient ionization sources coupled to fieldable mass spectrometers for optimum sensitivity and specificity. With the use of triboelectric nanogenerators (TENGs), the charge required to produce gas‐phase ions for mass analysis can be obtained without the need for high‐voltage electrical circuitry, simplifying and lowering the cost of next‐generation mass spectrometry instruments.MethodsA sliding freestanding (SF) TENG was coupled to a toothpick electrospray setup for the purposes of testing if falsified medicines could be fingerprinted by this approach. Extracts from both genuine and falsified medicines were deposited on the toothpick and the SF TENG actuated to generate electrical charges, resulting in gas‐phase ions for both active pharmaceutical ingredients and excipients.ResultsOur previous work had shown that direct analysis in real time (DART) ambient mass spectrometry can identify the components of multiple classes of falsified antimalarial medicines. Experiments performed in this study show that a simple extraction into methanol along with the use of a SF TENG‐powered toothpick electrospray can provide similar detection capabilities, but with much simpler and rugged instrumentation, and without the need for compressed gases or high‐voltage ion source power supplies.ConclusionsTENG toothpick MS allows for rapid analyte ion detection in a safe and low‐cost manner, providing robust sampling and ionization capabilities.

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Ambient ionization and miniature mass spectrometry system for chemical and biological analysis

Cited by 102 publications

References 87 publications

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Direct Analysis and Quantification of Metaldehyde in Water using Reactive Paper Spray Mass Spectrometry

Triboelectric nanogenerator (TENG) mass spectrometry of falsified antimalarials

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