Ambient mass spectrometry: Direct analysis of dimethoate, tebuconazole, and trifloxystrobin on olive and vine leaves by desorption electrospray ionization interface

Rocca, Lucia Mainero; Cecca, Juri; L’Episcopo, Nunziata; Fabrizi, Giovanni

doi:10.1002/jms.3978

Cited by 14 publications

(5 citation statements)

References 35 publications

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“…Chlorpropham was found on potato surfaces; dimethoate, tebuconazole, and trifoxystrobin were found on olive and vine leaves; and atrazine residues were found on Chinese cabbage leaves using DESI-MS. The existence of matrix effects and limited accuracy are key limits for quantitative analysis on surfaces [147][148][149]. The utilization of portable mass spectrometers to conduct in situ analysis is one of the most appealing characteristics of ambient ionization sources.…”

Section: Optical Screening Methods For Pesticide Residue In Food Matr...mentioning

confidence: 99%

Advancement and New Trends in Analysis of Pesticide Residues in Food: A Comprehensive Review

Wahab

Muzammil

Nasir

et al. 2022

Plants

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Food safety is a rising challenge worldwide due to the expanding population and the need to produce food to feed the growing population. At the same time, pesticide residues found in high concentrations in fresh agriculture pose a significant threat to food safety. Presently, crop output is being increased by applying herbicides, fungicides, insecticides, pesticides, fertilizers, nematicides, and soil amendments. A combination of factors, including bioaccumulation, widespread usage, selective toxicity, and stability, make pesticides among the most toxic compounds polluting the environment. They are especially harmful in vegetables and fruits because people are exposed to them. Thus, it is critical to monitor pesticide levels in fruits and vegetables using all analytical techniques available. Any evaluation of the condition of pesticide contamination in fruits and vegetables necessitates knowledge of maximum residue levels (MRLs). We set out the problems in determining various types of pesticides in vegetables and fruits, including the complexity and the diversity of matrices in biological materials. This review examines the different analytical techniques to determine the target analytes that must be isolated before final consumption. Many processes involved determining pesticide residues in fruits and vegetables and their advantages and disadvantages have been discussed with recommendations. Furthermore, MRLs of target pesticide residues in fruit and vegetable samples are discussed in the context of data from the literature. The review also examines MRLs’ impact on the international trade of fruits and vegetables. Accurate, sensitive, and robust analytical procedures are critical to ensuring that pesticide levels in food products are effectively regulated. Despite advances in detection technology, effective sample preparation procedures for pesticide residue measurement in cereals and feedstuffs are still needed. In addition, these methods must be compatible with current analytical techniques. Multi-residue approaches that cover a wide range of pesticides are desired, even though pesticides’ diverse natures, classes, and physio-chemical characteristics make such methods challenging to assemble. This review will be valuable to food analysts and regulatory authorities to monitor the quality and safety of fresh food products.

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Section: Optical Screening Methods For Pesticide Residue In Food Matr...mentioning

confidence: 99%

Advancement and New Trends in Analysis of Pesticide Residues in Food: A Comprehensive Review

Wahab

Muzammil

Nasir

et al. 2022

Plants

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“…The lack of chromatographic separation led to a further issue: how to correlate analyte quantity and mass spectrometric signal. In the authors' previous works 55,61,66 it was noticed that there is a greater outcome stability when the concentration is linked to the area subtended by the signal curve rather than to its height. Therefore, all other method experiments, or analyses, were conducted using areas and DESI plate speed was kept fixed at 200 μm/s.…”

Section: Validation Resultsmentioning

confidence: 98%

“…The procedure of analysing multiple spots for each sample turned out to be useful for obtaining representative mean values able to improve method reproducibility. The number of independent samples to be analysed was statistically studied (see Section 3.6) in this project as well as in the authors’ previous works 61 …”

Section: Resultsmentioning

confidence: 99%

“…The analysis time, given five spots per sample and three lines per spot, was still short (5 min) due to the possibility of positioning the spots at about 1 cm from each other with the help of the engraved plate.The procedure of analysing multiple spots for each sample turned out to be useful for obtaining representative mean values able to improve method reproducibility. The number of independent samples to be analysed was statistically studied (see Section 3.6) in this project as well as in the authors' previous works 61. F I G U R E 3 Total ion current and corresponding images of dried blood drops, two contiguous spots showing 'coffee ring' on the first spot and 'volcano' effect on the second [Color figure can be viewed at wileyonlinelibrary.com]3.4 | DBS supportSupports, as well as DESI geometrical parameters and ionization solvent, play an essential role in DESI analysis both during sample evaporation and during detection.…”

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confidence: 99%

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Direct multiclass desorption electrospray ionization–tandem mass spectrometry method for the analysis of sleep inducers and ototoxic drugs in dried blood spots

Rocca

L’Episcopo

Gordiani

et al. 2022

Rapid Comm Mass Spectrometry

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Rationale An unconventional and innovative approach for the quantitative determination of 11 ototoxic and narcoleptic drugs in whole blood is described. The multiclass method allows the inclusion of the most widespread drugs on the market (antihistamines, antidepressants, antihypertensives, anxiolytics, opioids, Z‐drugs) responsible for 10% of occupational accidents. Methods The developed procedure involved the use of the desorption electrospray ionization (DESI) interface for the direct analysis of dried blood spots (DBS). All the issues strictly connected to the chemical–physical characteristics of DBS and DESI (sample inhomogeneity, DBS support, DESI geometry and solvent) were carefully evaluated and innovative strategies were applied. Haematocrit was managed using a small and measured volume of blood (2 μL) with analysis of the entire DBS. Results The proposed method was fully validated in terms of limits of detection, limits of quantitation (LOQs; between 60 pg/mm2 and 1.6 ng/mm2), linearity (one order of magnitude starting from LOQs) and inter‐ and intra‐day precision (on three levels, with relative standard deviation values not exceeding 17%). Accuracy was calculated by comparison with an ultrahigh‐performance liquid chromatography–tandem mass spectrometry method (suitable also as a confirmatory method). Conclusions Results showed a surprising sensitivity, demonstrating that this procedure could be suitable for applications in various fields, e.g. forensic analysis. Moreover, as a collateral benefit, it was discovered that the method is able to analyse very light traces left on plastic and glass surfaces by detached dried blood.

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“…However, chromatography-mass spectrometry techniques are time-consuming, and the pretreatment process is laborious. In recent years, with the development of ambient MS, various atmospheric pressure ionization sources have been used for pesticide testing, including desorption electrospray ionization (DESI) [12][13][14], extractive electrospray ionization (EESI) [15,16], paper spray ionization (PSI) [17][18][19][20], probe electrospray ionization [21], and atmospheric plasma ionization sources, such as direct analysis on real time (DART) [22][23][24][25], atmospheric pressure chemical ionization (APCI) [26,27], and dielectric barrier discharge ionization (DBDI) [28][29][30][31]. These ion sources avoid complex pretreatment and chromatographic separation steps and offer multiple advantages.…”

Section: Introductionmentioning

confidence: 99%

A Novel Integrated APCI and MPT Ionization Technique as Online Sensor for Trace Pesticides Detection

Zhao

Chu

Zhou

2022

Sensors

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The misuse of pesticides poses a tremendous threat to human health. Excessive pesticide residues have been shown to cause many diseases. Many sensor detection methods have been developed, but most of them suffer from problems such as slow detection speed or narrow detection range. So, the development of rapid, direct and sensitive means of detecting trace amounts of pesticide residues is always necessary. A novel online sensor technique was developed for direct analysis of pesticides in complex matrices with no sample pretreatment. The portable sensor ion source consists of an MPT (microwave plasma torch) with desolventizing capability and an APCI (atmosphere pressure chemical ionization), which provides abundant precursor ions and a strong electric field. The performance which improves the ionization efficiency and suppresses the background signal was verified by using pesticide standard solution and pesticide pear juice solution measurements with an Orbitrap mass spectrometer. The limit of detection (LOD) and the limit of quantization (LOQ) of the method were measured by pear juice solutions that were obtained in the ranges of 0.034–0.79 μg/L and 0.14–1 μg/L. Quantitative curves were obtained ranging from 0.5 to 100 μg/L that showed excellent semi-quantitative ability with correlation coefficients of 0.985–0.997. The recoveries (%) of atrazine, imidacloprid, dimethoate, profenofos, chlorpyrifos, and dichlorvos were 96.6%, 112.7%, 88.1%, 85.5%, 89.2%, and 101.9% with the RSDs ranging from 5.89–14.87%, respectively. The results show that the method has excellent sensitivity and quantification capability for rapid and direct detection of trace pesticide.

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Ambient mass spectrometry: Direct analysis of dimethoate, tebuconazole, and trifloxystrobin on olive and vine leaves by desorption electrospray ionization interface

Cited by 14 publications

References 35 publications

Advancement and New Trends in Analysis of Pesticide Residues in Food: A Comprehensive Review

Advancement and New Trends in Analysis of Pesticide Residues in Food: A Comprehensive Review

Direct multiclass desorption electrospray ionization–tandem mass spectrometry method for the analysis of sleep inducers and ototoxic drugs in dried blood spots

A Novel Integrated APCI and MPT Ionization Technique as Online Sensor for Trace Pesticides Detection

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