Ambulatory arterial stiffness index is associated with impaired left atrial mechanical functions in hypertensive diabetic patients: A speckle tracking study

Kalaycıoğlu, Ezgi; Gökdeniz, Tayyar; Aykan, Ahmet Çağrı; Hatem, Engin; Gürsoy, Ozan Mustafa; Çavuşoğlu, Gökhan; Çetın, Mustafa; Çelık, Şükrü

doi:10.5152/akd.2014.5796

Cited by 15 publications

(12 citation statements)

References 31 publications

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“…28 Conversely, the data on analogous interactions with respect to left atrium performance are scarce. 29 This study provides incremental information over prior papers by a comprehensive analysis of an array of potential contributors to left atrium strain impairment in the early stage of HHD, as well as by a collective assessment of the relationships between central/peripheral haemodynamics and derangements of both function and size of the left atrium.…”

Section: Discussionmentioning

confidence: 99%

Association of central blood pressure with left atrial structural and functional abnormalities in hypertensive patients: Implications for atrial fibrillation prevention

Przewlocka‐Kosmala

Jasic-Szpak

Rojek

et al. 2019

Eur J Prev Cardiolog

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Aims Functional and structural abnormalities of the left atrium have been demonstrated to be clinically and prognostically significant in a range of cardiovascular disorders, increasing the risk of atrial fibrillation. Among the potential contributors to these aberrations, central arterial factors remain insufficiently defined. Accordingly, we sought to investigate the determinants of left atrium abnormalities in hypertension, with special focus on central haemodynamics. Methods In this retrospective, cross-sectional study, 263 patients (age 63.8 ± 8.0 years) with uncomplicated hypertension underwent echocardiography including left atrium strain (LAS) and volume analysis, and central haemodynamics assessment using radial tonometry. Results Patients were grouped depending on LAS and left atrium volume index (LAVI), using externally validated cutpoints (34.1% for LAS and 34 ml/m2 for LAVI). The subset with lower LAS ( n = 124) demonstrated higher central (cPP) and brachial pulse pressure (bPP), ventricular- arterial coupling, left ventricular mass index (LVMI) and LAVI, and lower global left ventricular longitudinal strain and early diastolic tissue velocity (e′). Patients with higher LAVI ( n = 119) presented higher systolic blood pressure, cPP, bPP, central augmentation pressure, LVMI and E/e′ ratio and lower LAS. In multivariable analysis, cPP was independently associated with both LAS ( β = –0.22; p = 0.002) and LAVI ( β = 0.21; p = 0.003). No independent associations with left atrium parameters were shown for bPP. Conclusion Higher cPP is detrimentally associated with left atrium structural and functional characteristics, thus providing a possible pathophysiological link with the development of substrate for atrial fibrillation. Prophylaxis of atrial fibrillation might be another argument for consideration in the treatment strategy in hypertension targeted measures addressing central blood pressure.

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Section: Discussionmentioning

confidence: 99%

Association of central blood pressure with left atrial structural and functional abnormalities in hypertensive patients: Implications for atrial fibrillation prevention

Przewlocka‐Kosmala

Jasic-Szpak

Rojek

et al. 2019

Eur J Prev Cardiolog

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“…Aix values were found to be correlated with serum asymmetrical dimethylarginine (ADMA) levels in newly diagnosed hypertensive patients ( 14 ). Furthermore, it has been previously shown that prediabetes and newly diagnosed diabetes patients have increased arterial stiffness and markers of ED through rising blood glucose levels ( 15 , 16 ). Increased PWV measurements in FMF patients may reflect increased cardiovascular risk.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the arterial stiffness and associated factors in patients with familial Mediterranean fever

et al. 2016

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Objective:Because of the ongoing and recurring inflammatory state in familial Mediterranean fever (FMF), patients may experience a high risk of cardiovascular events. Our aim was to investigate the arterial stiffness and associated factors in patients with FMF.Methods:Sixty-nine consecutive FMF patients (including 11 females) and 35 controls (including 5 females) were enrolled in the study. The demographical, clinical, and laboratory data and genetic mutations of the patients were recorded. In the study, FMF patients according to the Tel-Hashomer criteria were included, whereas patients with other known inflammatory rheumatologic disease, atherosclerotic cardiovascular disease, hypertension, diabetes, those under the age of 18 years, or those refusing to participate in the study were excluded. Arterial stiffness measurements were performed using the TensioMed device (TensoMed Ltd, Budapest, Hungary).Results:The patient and control groups were similar in terms of the mean ages, BMIs, gender, systolic blood pressures, and smoking. FMF patients had a higher pulse wave velocity (PWV) (7.73±1.3 and 7.18±1.1 m/s; p=0.03) and lower brachial and aortic augmentation indexes (–64.6±14.6% and –54.6±25.9%, p=0.041 and 4.9±7.4% and 14.0±11.5%, p=0.025, respectively) compared with the controls. Thirty-one (45%) patients were in the “during-attack” state and had higher PWV (8.17±1.6 and 7.38±0.9 m/s; p=0.027) compared with the asymptomatic patients. PWV was correlated to serum CRP, WBC, ESR, fibrinogen, and neutrophil/lymphocyte ratios (r=0.666, 0.429, 0.441, 0.388, and 0.460, respectively). The genetic mutation and predominant attack type had no effect on arterial stiffness.Conclusion:FMF patients have increased arterial stiffness during attacks compared with asymptomatic patients and controls. The impaired arterial stiffness is correlated to the severity of the inflammatory state rather than to the attack type or genetic mutations.

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“…Our results are in concordance with this study, but we evaluated the effects of lead exposure on arterial stiffness by using AASI, which was found to be significantly higher than that of the control group. As an indicator of arterial stiffness, AASI has been associated with an increased risk of cardiovascular morbidity and mortality in various clinical settings ( 17 , 18 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the ambulatory arterial stiffness index in lead-exposed workers

Karakulak

Yılmaz²,

Tutkun³

et al. 2017

Anatol J Cardiol

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Objective:Lead exposure has been associated with various cardiovascular disorders. It may also cause increased inflammation and fibrosis in the arterial system resulting in an increase in arterial stiffness. In this study, the ambulatory arterial stiffness index (AASI), which is a technique that measures arterial stiffness, was evaluated in occupationally lead-exposed workers.Methods:In this cross-sectional study, 68 lead-exposed workers without known cardiovascular risk factors and 68 healthy subjects were evaluated according to the 24-hour ambulatory blood pressure monitorization (ABPM) profiles and blood and 24-hour urine lead levels. A regression slope of diastolic over systolic blood pressure (BP) was computed in each participant. AASI was defined as 1 minus the regression slope.Results:There were no significant differences in terms of baseline demographic, clinical, echocardiographic characteristics, and ABPM profiles between the groups. In lead-exposed workers, the mean age was 34.7±8.1 years, and the median blood and urine lead levels were 40.5 µg/dL and 34.9 µg/L, respectively. AASI was 0.42±0.10 in lead-exposed workers and 0.37±0.10 in control subjects (p=0.007). In correlation analysis, AASI was correlated with both blood (r=0.417, p<0.001) and urine lead (r=0.242, p=0.047) levels. In regression analysis, blood lead level was found to be associated with AASI (b=0.086, p<0.001).Conclusion:AASI, which is an indicator of arterial stiffness, was found to be higher in lead-exposed workers than in healthy individuals. Increased AASI may be considered an early sign of arterial involvement in case of lead exposure.

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Ambulatory arterial stiffness index is associated with impaired left atrial mechanical functions in hypertensive diabetic patients: A speckle tracking study

Cited by 15 publications

References 31 publications

Association of central blood pressure with left atrial structural and functional abnormalities in hypertensive patients: Implications for atrial fibrillation prevention

Association of central blood pressure with left atrial structural and functional abnormalities in hypertensive patients: Implications for atrial fibrillation prevention

Investigation of the arterial stiffness and associated factors in patients with familial Mediterranean fever

Evaluation of the ambulatory arterial stiffness index in lead-exposed workers

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