This Section of Epidemiology and Psychiatric Sciences regularly appears in each issue of the Journal to stress the relevance of epidemiology for behavioural neurosciences, reporting the results of studies that explore the use of an epidemiological approach for providing a better understanding of the neural basis of major psychiatric disorders and, in turn, the utilisation of the behavioural neurosciences for promoting innovative epidemiological research.The final scope is to help the translation of most relevant research findings into every-day clinical practice. These contributions are written in house by the journal's editorial team or commissioned by the Section Editor (no more than 1000 words, short unstructured abstract, 4 key-words, one Table or Although we have gained enormous insights into neurobiological and psychological underpinnings of bipolar disorder (BD) symptoms, our knowledge concerning pathogenic mechanisms initiating recurrent affective episodes is still fragmentary. Previous research has highlighted the role of significant life events and social rhythm in recurrent episodes of mania and depression. However, most studies share the drawback of retrospective self-report data, which are prone to recall biases and limited introspective abilities. Therefore, more objective data, such as neuropsychological and neurobiological measures are needed to further unravel the pathogenic mechanisms of the dynamics of bipolar disorder. Previous research has highlighted disturbed emotional reactivity as well as impaired emotion regulation and impulse control as major behavioural characteristics of BD and aberrancies in prefrontal-limbic-striatal networks that have been proposed to be the correlates of these behavioural alterations. However, longitudinal studies assessing these neural and behavioural alterations are rare. Future research should therefore adopt prospective study designs including behavioural and neuroimaging measures underlying cognitive, emotional and motivational deficits in bipolar disorder. Particularly, these measures should be collected continuously at multiple time points as implemented in modern ambulatory assessment tools. Bipolar disorder (BD) is a highly severe and chronic mental condition with a lifetime prevalence of 2-4% for its most common subtypes (i.e., type I/II). Given the chronic and episodic course of the disease the prediction of recurrent manic and depressive episodes is a major, though not adequately resolved clinical and research question. On a phenomenological level the disease is characterised by phases of (hypo)mania, a state of elevated mood, increased energy, risk-taking and reduced sleep and phases of depression, best described by feelings of sadness, hopelessness, loss of energy and reduced sensitivity to positive outcomes. It has been proposed that increased emotional reactivity, deficient emotion regulation and impulse control as well as motivational dysregulation are important * Address for correspondence: M. Wessa, Department of Clinical Psychology and Neurop...