Ambulatory ECG‐Based T‐Wave Alternans Predicts Sudden Cardiac Death in High‐Risk Post‐MI Patients with Left Ventricular Dysfunction in the EPHESUS Study

Abstract

AECG-based TWA measured with MMA is a powerful predictor of SCD in high-risk post-MI patients with LV dysfunction.

Simultaneous Assessment of T-Wave Alternans and Heart Rate Turbulence on Holter Electrocardiograms as Predictors for Serious Cardiac Events in Patients After Myocardial Infarction

“…1-4 Recent studies have reported that TWA using the modified moving average method (MMA-TWA) based on the time-domain algorithm of TWA measurement, which can be assessed simply using 24-h Holter ECGs is also a significant index for cardiac events. [5][6][7] Heart rate turbulence (HRT) is a measure of autonomic response to perturbation of arterial blood pressure after ventricular premature contractions (VPCs) and has been also introduced as a risk stratification marker for serious cardiac events. 8- 11 However, no prospective study has described the clinical utility of these markers in a simultaneous assessment, and there is no available information of a comparison of the 2 markers for risk stratification for serious cardiac events.…”

Ambulatory ECG-Based T-Wave Alternans and Heart Rate Turbulence Predict High Risk of Arrhythmic Events in Patients With Old Myocardial Infarction

“…Recently, the introduction of a time domain-based method of TWA, termed the "modified moving average" (MMA) analysis, has expanded the application and utility of TWA to ambulatory ECG. [9][10][11][12] HRT is a measure of the autonomic response to perturbations of arterial blood pressure (BP) after a single premature ventricular contraction (PVC). HRT correlates significantly with baroreflex sensitivity and consists of a short initial acceleration followed by deceleration of the HR.…”

National Russian Guidelines on Application of the Methods of Holter Monitoring in Clinical Practice

“…B. Nearinng и R. Verrier разработали новый метод временной оценки МАТ, так называемый Modified Moving Average (MMA) метод, который может быть использован, как при ХМ, так при стресс-тестах [102]. Было проведено несколько крупных ретро-спективных [103,104] и проспективных [105,106] исследований, в которых показано, что значение отрезной точки МАТ выше 65 микровольт (μV) ассоциируется с риском высокой смертности во взрослой популяции [101]. Значения МАТ в дан-ном исследовании у больных с кардиоваскулярной патологией и остановкой сердца составили 72±20 μV против 52±15 μV у больных без жизне-угрожающих состояний.…”