Ameliorating effect of lyophilized extract of<i>Butea frondosa</i>leaves on scopolamine-induced amnesia in rats

Malik, Jai; Kumar, M. Jyothi; Deshmukh, Rahul; Kumar, Puneet

doi:10.3109/13880209.2012.717229

Cited by 18 publications

(11 citation statements)

References 26 publications

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“…In our study, as expected, scopolamine significantly impaired learning and memory in MWM test. It has been described that scopolamine induces impairment of short memory and acquisition of new knowledge and also increases AChE activity and oxidative stress in the brain [38]. In fact, scopolamine blocks cholinergic neurons pharmacologically and causes impairment of learning and memory in experimental animals [39].…”

Section: Discussionmentioning

confidence: 99%

Tadalafil Reversed H-89 – and Scopolamine – Induced Spatial Learning Impairments in Male Rats

et al. 2021

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Accumulated evidence shows that the cAMP and cGMP signaling pathway plays an important role in memory function and neuronal plasticity. Phosphodiesterase 5 (PDE5) is a hopeful therapeutic target in AD (Alzheimer disease), and PDE5 inhibition may be a good therapeutic strategy for the treatment of AD. In the present study, the four-day bilateral intra-hippocampal infusion of H-89 as a protein kinase AII inhibitor (10 µM/side) and intra-peritoneal injections of tadalafil (20 mg/kg) and scopolamine (0.5 mg/kg) alone and also on combination on spatial learning in Morris water maze (MWM) were investigated. DMSO and saline were used as controls for H-89 and other mentioned drugs, respectively. Rats were trained for 4 days; each day included one block of four trials. Post- training probe trial tests were performed on day 5. Administration of H-89 and scopolamine led to a significant impairment in spatial learning compared to their related controls. But, combination of tadalafil/H-89 or tadalafil/scopolamine reversed H-89 or scopolamine- induced spatial learning deficits in MWM. Taken together, these results showed the probable regulatory effects of cGMP on cholinergic and cAMP/PKA signaling pathways in co-administrations of these mentioned drugs on spatial learning in MWM.

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Section: Discussionmentioning

confidence: 99%

Tadalafil Reversed H-89 – and Scopolamine – Induced Spatial Learning Impairments in Male Rats

et al. 2021

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“…It may be considered that resulted radicals of hydrogen peroxide catalyzed by increased CAT enzymes. An increase in GSH level, a thiol based endogenous antioxidant acts as a co substrate, accelerates the GPx assisted reaction by reduction of peroxides, such as lipid and hydrogen peroxides ( Malik et al, 2013 ). It has been demonstrated that scopolamine associated increase in oxidative stress direct increased lipid peroxidation and reduced SOD, CAT, and GPx in rat brain, which causes memory impairment and neuronal cell death ( Jeong et al, 2008 ; Pahaye et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Prosopis cineraria (L.) Druce and Its ZnO Nanoparticles on Scopolamine Induced Amnesia

et al. 2018

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Over recent years, utilization of green synthesized nanomaterials has been widely growing on human body because of its special properties. With the increasing acceptance of nanoparticle approach for various clinical treatments, the biosafety and toxicological effects on the vital organs such as central nervous system, have received more concern. Main focus of this study was to evaluate acute exposure of n-butanol fraction of Prosopis cineraria (L.) Druce hydroethanolic extract (BuPC) and green synthesized zinc oxide nanoparticles of BuPC (ZnOPC) on spatial cognition behavior, and to assess underlying mechanism by estimation of enzymatic antioxidative status along with acetylcholinesterase (AChE) activity in mice brain. Strongest in vitro antioxidant and AChE inhibitory activity exhibiting fraction, BuPC, was examined for inhibition kinetic study by Lineweaver–Burk and Dixon plots. BuPC was further used for fabrication ZnOPC and characterized by UV-visible spectroscopy, Fourier Transform Infrared (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X ray (EDX), and Dynamic Light Scattering (DLS) analysis. Old male swiss albino mice were randomly divided into seven groups and treated for 21 days. Subsequently spatial memory was determined by two behavioral models [Elevated plus maze (EPM) and Hebbs William maze (HWM)] and supernatant of brain homogenate was analyzed for enzymatic antioxidant level and AChE inhibitory activity. Zinc content of blood plasma and brain was estimated. Results showed prolonged transfer latency (TL) and time taken to reach reward chamber (TRC) by scopolamine was not ameliorated by the ZnOPC group, whereas BuPC group showed significant reduction in scopolamine induced increase in TL and TRC compared to control and scopolamine treated groups. ZnOPC alleviated enzymatic antioxidant activity and AChE as compared to donepezil and BuPC treated groups. Study concludes that ZnOPC attenuated spatial learning and memory by increase in oxidative stress and decrease in AChE activity at both dose levels. Our results suggest that BuPC exhibited a strong neuroprotective effect on cognitive deficit mice and it may be employed as a strong substance for the treatment of dementia whereas the green synthesized ZnOPC was not proficient to reverse the memory impairment induced by scopolamine.

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“…On day 16, the platform was removed and the animal was randomly released at any one of the edges (N, S, E, and W) facing the wall of the pool and tested for the retention of the memory. The time spent in the target quadrant (where the platform was placed) was recorded (Kumar & Kumar, 2009a;Malik et al, 2013). The higher value of the time spent in quadrant indicates better retention ability as the animal remembered the position of the platform.…”

Section: Morris Water Maze Testmentioning

confidence: 99%

Protective effect ofConvolvulus pluricaulisstandardized extract and its fractions against 3-nitropropionic acid-induced neurotoxicity in rats

Malik

Choudhary

Kumar

2015

Pharmaceutical Biology

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Context: Convolvulus pluricaulis Chois. (Convolvulaceae), a well-known Ayurvedic ''Medhya Rasayana'' (nervine tonic), is extensively used for different central nervous system (CNS) disorders. Objective: The objective of this study was to evaluate the protective effect of standardized hydro-methanol extract of C. pluricaulis (CPE) and its fractions, namely ethyl acetate (EAE), butanol (BE), and aqueous (AE), against 3-nitropropionic acid (3-NP) induced neurotoxicity in rats. Materials and methods: The extract of the whole plant was standardized on the basis of scopoletin content (0.014%) using thin layer chromatography densitometric analysis. CPE (100 and 200 mg/kg) and its fractions, namely EAE (15 and 30 mg/kg), BE (25 and 50 mg/kg), and AE (50 and 100 mg/kg) were administered orally for 20 d. Their protective effect against 3-NP (10 mg/kg, i.p. for 14 d) was assessed by the effect on various behavioral parameters, namely body weight, locomotor activity, grip strength, gait pattern, and the effect on cognitive dysfunction. Biochemical parameters for oxidative damage were also assessed in the striatum and cortex regions of the brain.

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Ameliorating effect of lyophilized extract ofButea frondosaleaves on scopolamine-induced amnesia in rats

Cited by 18 publications

References 26 publications

Tadalafil Reversed H-89 – and Scopolamine – Induced Spatial Learning Impairments in Male Rats

Tadalafil Reversed H-89 – and Scopolamine – Induced Spatial Learning Impairments in Male Rats

Comparative Evaluation of Prosopis cineraria (L.) Druce and Its ZnO Nanoparticles on Scopolamine Induced Amnesia

Protective effect ofConvolvulus pluricaulisstandardized extract and its fractions against 3-nitropropionic acid-induced neurotoxicity in rats

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