2019
DOI: 10.1016/j.lfs.2019.06.009
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Amelioration of fenitrothion induced oxidative DNA damage and inactivation of caspase-3 in the brain and spleen tissues of male rats by N-acetylcysteine

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Cited by 35 publications
(15 citation statements)
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“…Environmental contaminants especially pesticides are now responsible for the development of diseases both in wildlife and humans ( Ye et al, 2013 , Shin et al, 2017 ). Humans are exposed to these pesticides either directly as agricultural workers or indirectly through food consumption ( Alam et al, 2019 ). Herbal medicines can be defined as raw or extracted products isolated from plants, and they are widely used for prevention and treatment of many chronic diseases because they have fewer side effects compared with pharmacological drugs ( Park et al, 2011 ).…”
Section: Discussionmentioning
confidence: 99%
“…Environmental contaminants especially pesticides are now responsible for the development of diseases both in wildlife and humans ( Ye et al, 2013 , Shin et al, 2017 ). Humans are exposed to these pesticides either directly as agricultural workers or indirectly through food consumption ( Alam et al, 2019 ). Herbal medicines can be defined as raw or extracted products isolated from plants, and they are widely used for prevention and treatment of many chronic diseases because they have fewer side effects compared with pharmacological drugs ( Park et al, 2011 ).…”
Section: Discussionmentioning
confidence: 99%
“…For the studies, we chose fenitrothion (FN), a synthetic insecticide from the group of organophosphates, that despite its toxicity and latest withdrawal from sale by the law in European countries, is commonly used in food storage facilities in many countries worldwide. Moreover, FN is very well-studied for its chemical and physiological properties, as evidenced by numerous studies, including reports about its influence on insects [ 22 , 23 , 24 , 25 ], rodents [ 26 , 27 , 28 ], and humans [ 29 , 30 , 31 ]. Therefore, this pesticide is a good model for the tests of organophosphates’ toxicity.…”
Section: Introductionmentioning
confidence: 99%
“…The ROS/RNS‐induced DNA damage is another way for the induction of apoptosis through p53 69 . This gene arrests the cell sequence at the late G1 stage and the p21 is the primary mediator of this process 70 .…”
Section: Discussionmentioning
confidence: 99%