Amelioration of isoniazid and rifampicin-induced liver toxicity by Amaranthus graecizans subsp. silvestris in rat

Ishtiaq, Saiqa; Afridi, Muhammad Shaharyar Khan; Masood, Nawal

doi:10.3329/bjp.v12i3.32985

Cited by 4 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blood samples were drawn from the anaesthetized animals by cardiac puncture in sterile heparinized tubes and allowed to clot for 30 min. Serum was separated from the blood by centrifugation process and used for the assay of serum marker enzymes [16].…”

Section: Evaluation Of Hepatoprotective Activitymentioning

confidence: 99%

Evaluation of anti-nociceptive, anti-inflammatory and hepatoprotective effects of methanol extract of Mazus pumilus (Burm. f.) Steenis (Mazaceae) herb

Ishtiaq¹,

Ilyas²,

Irshad³

et al. 2021

Trop. J. Pharm Res

Self Cite

View full text Add to dashboard Cite

Purpose: This study was designed to investigate the anti-nociceptive, anti-inflammatory and hepatoprotective activities of the methanol extract of Mazus pumilus (Mazaceae) herb. Methods: Anti-nociceptive activity was determined using hot plate, tail flick and acetic acid-induced writing methods. Carrageenan-induced rat paw edema (0.1 mL of 1 %) model was used for the assessment of anti-inflammatory activity. The methanol extract was administered orally at three different doses (150, 300 and 600 mg/kg) to three separate groups in all the experiments. Diclofenac sodium (50 mg/kg) was used as standard drug while control group received DMSO (1 %, 10 mL/kg). The hepatocurative effect of methanol extract of M. pumilus (400 mg/kg) was determined in isoniazid (50 mg/kg) and rifampicin (100 mg/kg) induced liver injury. Silymarin (100 mg/kg) was used as standard drug for comparison. The control group received distilled water (10 mL/kg). Preliminary phytochemical screening was also carried out. Results: The methanol extract of M. pumilus significantly (p < 0.05) augmented latency time and reduced the number of writhes in the pain models at all doses used for the assessment of antinociceptive actions. The anti-inflammatory activity of different doses of extract was evaluated by measuring the reduction in the size of the paw. A significant (p < 0.05) hepatocurative effect was observed when administered after anti-tuberculosis drugs. Histopathological analysis of the liver tissues also revealed restored hepatocellular architecture. Conclusion: The results demonstrate the anti-nociceptive, anti-inflammatory and hepatoprotective effects of the methanol extract of M. pumilus, thus substantiating the ethnomedical claims associated with the herb.

show abstract

Section: Evaluation Of Hepatoprotective Activitymentioning

confidence: 99%

Evaluation of anti-nociceptive, anti-inflammatory and hepatoprotective effects of methanol extract of Mazus pumilus (Burm. f.) Steenis (Mazaceae) herb

Ishtiaq¹,

Ilyas²,

Irshad³

et al. 2021

Trop. J. Pharm Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Whole plant was extracted with 90 % aqueous methanol, and extract was active against isoniazid and rifampicin-induced hepatotoxicity. 278…”

Section: Hepatoprotectionmentioning

confidence: 99%

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

Azab¹

2020

ECB

View full text Add to dashboard Cite

“…The fixed tissues were processed routinely and then fixed in paraffin, sectioned, de-paraffinized and rehydrated. The 7 μm thick sections of liver than stained with alum haematoxylin and eosin for nuclei and cytoplasm staining into blue/purple and pink respectively were observed microscopically for histopathological changes 21 .…”

Section: Reduced Glutathione (Gsh)mentioning

confidence: 99%

Hepatoprotective Role of Lovastatin - Pregnane X Receptor Agonist in Lithocholic Acid Induced Liver Cholestasis Diseased Rats

Nain

Dhingra

Jaspreet

2019

JBPR

View full text Add to dashboard Cite

Objective: Pregnane X receptor (PXR), member of nuclear receptor family, an integral component of the body defence mechanism against chemical insult are expressed in the liver, gastrointestinal system & lungs. Some studies have shown that the lovastatin is pregnane X receptor (PXR) activation effect. Methods: In the present study the hepatoprotective effect of lovastatin was investigated against lithocholic acid induced liver toxicity. Liver markers in serum and antioxidant enzymes in liver tissue were assessed by using standard procedures. Results: The level of liver marker (such as SGOT & SGPT) and bilirubin were increased significantly (p<0.05) and antioxidant enzyme (i.e. SOD, GSH and CAT) were significantly (p<0.05) decrease in lithocholic acid treated groups as compared to control group. Lovastatin at doses of 0.1, 0.2, 0.3 mg/kg showed significantly (p<0.05) decrease in the levels of liver marker (SGOT & SGPT) and bilirubin as compared to the positive control group in both pre & post treated models. The antioxidant enzymes such as Superoxide dismutase (SOD), Glutathione (GSH) and Catalase (CAT) content in liver tissue were significantly (p<0.05) increase after administration of lovastatin at dose dependent manner in both pre & post treated models. Conclusions: The results of the present study indicates that under the present experimental conditions, lovastatin showed hepatoprotective abilities against lithocholic acid induced hepatotoxicity in albino rat. Keywords: Hepatoprotection, lovastatin, Lithocholic Acid, Pregnane X Receptor

show abstract

Amelioration of isoniazid and rifampicin-induced liver toxicity by Amaranthus graecizans subsp. silvestris in rat

Cited by 4 publications

References 20 publications

Evaluation of anti-nociceptive, anti-inflammatory and hepatoprotective effects of methanol extract of Mazus pumilus (Burm. f.) Steenis (Mazaceae) herb

Evaluation of anti-nociceptive, anti-inflammatory and hepatoprotective effects of methanol extract of Mazus pumilus (Burm. f.) Steenis (Mazaceae) herb

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

Hepatoprotective Role of Lovastatin - Pregnane X Receptor Agonist in Lithocholic Acid Induced Liver Cholestasis Diseased Rats

Contact Info

Product

Resources

About