Ameliorative Effect of Different Concentration of Mushroom (<i>Pleurotus Tuberregium</i>) on Pathomorphological Changes Induced By Lead Toxicity in Liver and Kidney of Wistar Albino Rats

Abstract

This study evaluates ameliorative effect of different concentrations of mushroom (Pleurotus tuberregium) on the effects of lead (Pb). Ninety albino rats were divided into six groups with three replicates (5 rats per group) for 21 days pre-experimental stage for acclimatization. The experimental groups were exposed to 0.1 g/l of lead daily for 21 days. At the end of exposure period, lead salt was discontinued for 21 and 42days to verify possible ameliorative effect of mushroom in the post-experimental stage. Samples of liver and kidney tissues were then collected and subsequently analyzed for structural changes every 21 days. The tissues of the pre-experimental stages showed normal tissues as those of the control except in the liver which showed mild periportal chronic inflammatory cell. However, the experimental groups, showed liver with focal periportal vascular congestion and hypertrophy, moderate chronic inflammatory cell infiltration and interstitial oedema. The kidney showed focal proximal tubular necrosis, transmural oedema, interstitial haemorrhage, and chronic inflammatory cell infiltration. The tissues of liver and kidney in the post experimental stages were improved with increased mushroom content in the feed. Results of this study demonstrated that P. tuberregium may ameliorate lead toxicity in liver and kidney tissues.

In vitroAntimicrobial andin vivoLead Acetate Poison Abatement Study ofGarcinia kolaHeckel

“…Based on the premise that free radicals are generated during the pathogenesis due to chronic lead exposure, chelation by the supplementation with antioxidants or displacement reaction therapies are suitable alternative treatments for some heavy metal poisoning [16][17][18]. Lead (Pb) has no physiological role in biological systems [19] and is one of the most commonly implicated heavy metals in the Nigerian environment, especially in oil polluted, mining and urban areas. The paradigm shift in the economic mainstay of crude oil to radical natural mineral mining activities in Nigeria has led to increased incidents of lead poisoning, morbidity and mortality, resulting from saturnism.…”