Ameliorative Effect of Grape Seed Proanthocyanidin Extract on Cadmium‐Induced Meiosis Inhibition During Oogenesis in Chicken Embryos

Hou, Fuyin; Xiao, Min; Li, Jian; Cook, Devin; Zeng, Weidong; Zhang, Caiqiao; Mi, Yuling

doi:10.1002/ar.23320

Cited by 16 publications

(12 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have shown that GSPE could alleviate arsenic and cisplatin-induced oxidative stress in the testes of rodents [ 35 , 36 ]. Our previous study demonstrated that GSPE alleviated Cd-induced meiotic abnormalities of the ovarian tissues in chicken embryos [ 37 ]. In the present study, we investigated the effects of aging on ovary antioxidant status via comparing ovarian histology, antioxidants, and oxidants in the ovary and the expression levels of genes related to antioxidant capacity in ovaries of hens in different laying stages.…”

Section: Discussionmentioning

confidence: 99%

Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens

Liu

Lin

et al. 2018

Oxidative Medicine and Cellular Longevity

Self Cite

107

View full text Add to dashboard Cite

Oxidative stress is an important inducement in ovarian aging which results in fecundity decline in human and diverse animals. As a potent antioxidant, grape seed proanthocyanidin extract (GSPE) was investigated to ameliorate chicken ovarian aging in this study. Firstly, ovarian antioxidant capacity of hens at different ages (90, 150, 280, and 580 days old) was compared to elucidate its age-related changes. Subsequently, a D-gal-induced (2.5 mg/mL) aging ovarian model was established and the cultured ovarian tissues were treated with GSPE at 5 μg/mL for 72 h to evaluate the putative attenuating effects of GSPE on ovarian aging. Meanwhile, ovaries of D280 (young) and D580 (old) were treated with GSPE for 72 h in culture to verify the protective effects of GSPE on natural aging ovary. The results showed that GSPE could rescue the antioxidant capacity decline by increasing the antioxidase activities and their gene expression in either D-gal-induced or natural aging ovaries. Moreover, GSPE could maintain the homeostasis between cell proliferation and apoptosis in the D-gal-induced and natural aging ovaries, as well as alleviate D-gal-induced nucleus chromatin condensation in the ovarian granulosa cells. In conclusion, GSPE treatment can effectively prevent the ovarian aging process in hens by reducing oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens

Liu

Lin

et al. 2018

Oxidative Medicine and Cellular Longevity

Self Cite

107

View full text Add to dashboard Cite

show abstract

“…At morphological level, grape seed proanthocyanidins exerted positive effects in rat erythrocytes [34]. Simultaneous supplementation of grape seed proanthyocianidin extract (150 µg/egg) markedly improved the morphological alterations induced by cadmium as a result of upregulating meiosis-related proteins and gene expressions and restoring the antioxidant activity in embryo cells [35].…”

Section: Red Blood Cellsmentioning

confidence: 99%

Are Grapes Able to Mitigate the Noxious Effects Induced by Cadmium Exposure in Different Tissues and/or Organs? A Mini Review

et al. 2018

View full text Add to dashboard Cite

Grapes are fruits that grow in clusters and can be crimson, black, dark blue, yellow, green, orange, and pink. Cadmium is a non-essential metal toxic to living organisms and the environment. Recently, health professionals, food scientists, and consumers have paid much attention to grapes for their health-promoting effects. To the best of our knowledge, there are no reviews describing the ability of grapes to mitigate the toxic effects induced by cadmium exposure in different tissues and/or organs. Herein, the aim of this review is to present the effects of grapes following cadmium exposure on the number of papers published in the scientific literature. The results showed that grapes are able to mitigate the harmful activities induced by exposure to cadmium in several tissues and organs. The main actions are closely related to tissue regeneration as a result of the reestablishment of morphology and antioxidant activity. However, further studies are welcomed in order to elucidate new biological pathways regarding the outcomes promoted by grapes in this context, specially related to inflammation, tissue regeneration and cellular death.

show abstract

“…At the opposite in the literature, a dietary selenium (antioxidant) supplementation increased hatchability and reduced embryonic mortality rate (48,49). Furthermore, using in ovo injection (at embryonic day 6.5), GSE has been shown to protect chicken embryos against Cadmium, an endocrine disruptor (29).…”

Section: Gse Supplementation Did Not Affect the Fertility Parametersmentioning

confidence: 99%

“…Recently, we showed that GSE treatments reduced OS and improved in vitro steroidogenesis without affecting cell proliferation and viability in human granulosa cells (27). In hens, grape seed proanthocyanidin extract could prevent the ovarian aging process by reducing oxidative stress (28) and could provide some protection against the reproductive toxicity induced by the Cadmium endocrine disruptor (29). However, no studies investigated the in vivo effects of the GSE on the egg performance (quantity and quality) and on the fertility parameters.…”

Section: Introductionmentioning

confidence: 99%

A grape seed extract maternal dietary supplementation improves egg quality and reduces ovarian steroidogenesis without affecting fertility parameters in reproductive hens: a link with plasma and ovarian cell adipokines expression?

Barbe

Mellouk

Ramé

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: In mammals, oxidative stress (OS) induces negative effects on reproductive functions. In broiler hens, the genetic selection has increased susceptibility to OS. Grape seed extracts (GSE) are known as potent antioxidants. Here, we investigated the effects of time and level of GSE dietary supplementation on egg production and quality, fertility parameters, Reactive Oxygen Species (ROS) and steroid content in yolk egg associated to plasma adipokines in broiler hens. Methods: We designed an in vivo study using four groups of hens: A (control), B and C (supplemented with GSE at 0.5% and 1% of the total diet composition, respectively, starting at week 4) and D (supplemented with GSE at 1% of the total diet composition since hatching). We assessed the egg production from 23 th to 40 th weeks and quality at 33 th week. After artificial inseminations, the fertility parameters were calculated. In egg yolk, Reactive Oxygen Species (ROS) level and steroid production were evaluated by Ros-Glo H202 and ELISA assay, respectively. Expression of steroidogenic enzymes and adipokines and their receptors was determined by RT-qPCR in ovarian cells and plasma adipokines (RARRES2, ADIPOQ and NAMPT) were evaluated by specific ELISA assays. Results: The fertility parameters and egg production were unaffected by GSE supplementation. However, the rate of double-yolk eggs decreased for all GSE supplemented. Eggs from the C group were bigger and larger. The shell elasticity was higher for B and C groups. In the yolk egg, GSE supplementation reduced ROS content and steroidogenesis consistent with a decrease in P450 aromatase and StAR mRNA expression and basal in vitro progesterone secretion in granulosa cells. Interestingly, RARRES2 plasma levels were positively correlated while ADIPOQ and NAMPT plasma levels were negatively correlated, with steroids and ROS in yolk. Conclusions: Maternal dietary GSE supplementation did not affect egg production and fertility parameters whereas it reduced ROS content and steroidogenesis in yolk egg. Furthermore, it ameliorated egg quality by decreasing the number of double-yolk eggs and by improving the size of normal eggs and the elasticity of the shell. Taken together, our data suggest the possibility of using dietary maternal GSE to improve egg quality.

show abstract

Ameliorative Effect of Grape Seed Proanthocyanidin Extract on Cadmium‐Induced Meiosis Inhibition During Oogenesis in Chicken Embryos

Cited by 16 publications

References 40 publications

Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens

Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens

Are Grapes Able to Mitigate the Noxious Effects Induced by Cadmium Exposure in Different Tissues and/or Organs? A Mini Review

A grape seed extract maternal dietary supplementation improves egg quality and reduces ovarian steroidogenesis without affecting fertility parameters in reproductive hens: a link with plasma and ovarian cell adipokines expression?

Contact Info

Product

Resources

About