Ameliorative Effect Of Trigonella Foenum Graecum L. On Lipid Profile, Liver Histology and Ldl-Receptor Gene Expression in High Cholesterol-Fed Hamsters

Sm, Kassaee; Goodarzi, MT; Sn, Kassaee

doi:10.4183/aeb.2021.7

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Many studies have reported the hypercholesteremic and hypoglycemic activity of TFG. This effect is mainly attributed to the presence of flavonoids, dietary fibers, which restrict the absorption of lipids from the small intestine, and 4-hydroxy isoleucine which enhances LDL uptake by increasing the activity of lecithin cholesterol acyl transferase and by upregulation of LDL receptor gene expression and also the phytoestrogen content, a large amount of fiber galactose and mannose in the extract (Doyle et al 2009 ; Kassaee et al 2021 ). Estrogen reduces TC levels by increasing the expression of the hepatic LDL receptor.…”

Section: Discussionmentioning

confidence: 99%

Trigonella foenum-graecum L. seed extract modulates biochemical and histomorphological changes in therapeutic model of high-fat diet-fed ovariectomized rats

et al. 2023

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This study investigates the therapeutic effect of petroleum ether fraction of Trigonella foenum-graecum L. (PE-TFG) seed extract in ovariectomized rats fed with high-fat diet. Rats were randomly grouped into sham ovariectomy (S.OVX), ovariectomy + high-fat diet (OVX + HFD), and treatment groups. The blood samples were collected, and lipid profile, glucose, hepatic markers, and inflammatory markers were estimated. Liver, kidney, and common carotid artery were isolated for histopathological observations. Liver samples were tested for antioxidant, oxidative stress markers, mRNA expression of adiponectin, and PPAR-γ. PE-TFG treatment significantly decreased total cholesterol (18%), LDL (20%), hepatic markers (28%), leptin (17%), TNF-α (21%), and increased mRNA expression of adiponectin and PPAR-γ. There was also micro- and macro-hepatic steatosis, inflammation in the liver, deteriorated tubules in the kidney, and increased tunica intima and media thickness of the common carotid artery. These pathological alterations were reversed with PE-TFG administration. This impact might be linked to phytoestrogens and other components in PE-TFG such as diosgenin, phenols, and flavonoids.

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Section: Discussionmentioning

confidence: 99%

Trigonella foenum-graecum L. seed extract modulates biochemical and histomorphological changes in therapeutic model of high-fat diet-fed ovariectomized rats

et al. 2023

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“…The results are supported by previous studies. An article [9] reported that the aqueous solution of fenugreek leaves possesses significant activity against serum triglyceride and total cholesterol. Two more studies [30,31] on fenugreek seed powder and freeze-dried garlic cloves used as individual and in 10% and 2% combination, respectively, in a high cholesterol diet of rats for 8 weeks in a myocardial infarction model, reported that both herbal materials had significant effect on TC, TG, HDL, LDL on heart muscle and liver.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the traditional medicinal uses, fenugreek is found to have many pharmacological properties, such as anti-diabetic, anti-nociceptive, anticarcinogenic, anti-oxidant and anti-inflammatory [6,7]. The anti-cholesterol activity of fenugreek extracts has been well studied by researchers all over the world, and T. Fenograsicum leaves, seeds and extracted in different solvents are well reported as anti-hyperlipidaemic agent [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Preventive effects of <i>Trigonella foenum-graecum</i> and <i>Allium sativum</i> against Triton induced hyperlipidaemia in rabbits

IMRAN,

Sohail,

Khan

et al. 2023

J Pre Clin Clin Res.

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Introduction and Objective. Hyperlipidaemia is the greatest risk factor of coronary heart disease and currently available hypolipidemic drugs have been associated with number of side effects. Several studies have demonstrated the role of Trigonella foenum-graecum and Allium sativum in improvement of lipid profile and suggest their use as alternative and natural source for prevention / long term management of hyperlipidaemia. Materials and method. The study investigates synergetic antihyperlipidemic effects of polyherbal formulation containing T. foenum-graecum seeds and A. sativum buds (ratio 7:3) in Triton-induced acute hyperlipidaemia in rabbits, and compared with standard Atorvastatin. All animals were fed their respective samples orally without any base material for the period of one week. On day 7, blood samples were collected directly from the marginal ear vein of all rabbits before dosing. Immediately after the last dose, Triton WR-1339 (200 mg/kg i.p.) (Tyloxapol) (Sigma-aldrich Corp., USA) in normal saline was injected into all groups. After 24 h of Triton injection, blood samples were again collected from marginal ear vein of all animals for analysis of total cholesterol (TC), triglycerides (TG), HDL cholesterol and LDL cholesterol. Results. Seven days pretreatment of polyherbal formulation clearly demonstrated significant anti-hyperlipidaemic effects by showing TC 40.4 (p <0.05*), TG 36.6 (p <0.01**), HDL 25.8 and LDL 10.6 mg/dl (p <0.01**) in comparison with control group that exhibited TC 94.6, TG 812.6, HDL 20 and LDL 91.6 mg/dl lipid values. The standard group also exhibited potent results by showing TC 46, TG 198.6 (p <0.01**), HDL 37.6 (p <0.05*) and LDL 31.6 mg/dl (p <0.05*) values. Conclusion. The results obtained suggest that the regular use of a moderate amount of T. foenum-graecum and A. sativum in the diet may offer protection against hyperlipidaemia.

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The effect of the fenugreek hydrolyzed protein on lipid profile in patients with mild-to-moderate hypercholesterolemia: A confirmatory triple-blind randomized-controlled clinical trial

Badiee Gavarti,

Askari,

Roohafza

et al. 2025

Phytomedicine Plus

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Ameliorative Effect Of Trigonella Foenum Graecum L. On Lipid Profile, Liver Histology and Ldl-Receptor Gene Expression in High Cholesterol-Fed Hamsters

Cited by 3 publications

References 33 publications

Trigonella foenum-graecum L. seed extract modulates biochemical and histomorphological changes in therapeutic model of high-fat diet-fed ovariectomized rats

Trigonella foenum-graecum L. seed extract modulates biochemical and histomorphological changes in therapeutic model of high-fat diet-fed ovariectomized rats

Preventive effects of <i>Trigonella foenum-graecum</i> and <i>Allium sativum</i> against Triton induced hyperlipidaemia in rabbits

The effect of the fenugreek hydrolyzed protein on lipid profile in patients with mild-to-moderate hypercholesterolemia: A confirmatory triple-blind randomized-controlled clinical trial

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