Ameliorative effects of selenium nanoparticles on letrozole induced polycystic ovarian syndrome in adult rats

Butt, Maisra Azhar; Ullah, Asad; Kiyani, Mubin Mustafa; Jahan, Sarwat

doi:10.1504/ijbnn.2020.107184

Cited by 4 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No significant change was observed in the serum level of FSH. These results are similar to those reported by Butt et al [ 24 ] and Ryu et al [ 54 ].…”

Section: Discussionsupporting

confidence: 93%

“…Lipid profile parameters were normalized after treatment with SeNPs. Similar findings have been reported earlier by Butt et al [ 24 ] when SeNPs administrated at 50 and 100 mg/kg. The hypolipidemic effect of SeNPs may be attributed to the enhanced catabolism of cholesterol to bile acids and the suppression of cholesterol synthesis and LDL receptor activity [ 19 ].…”

Section: Discussionsupporting

confidence: 92%

“…In contrast, the treatment of PCOS rats with SeNPs returned the ovarian tissue to some extent to normal architectures with the appearance of follicles at different stages of development and a decreased number of cystic follicles. Several reports revealed similar results [ 24 ].…”

Section: Discussionsupporting

confidence: 74%

“…SeNPs treatment in the present study reversed the increment in the testosterone and LH levels and improved estradiol and progesterone levels. This could be explained by the ability of SeNPs to ameliorate the altered cystic follicles, antral follicles, and corpus luteum in PCOS rats [ 24 ]. Moreover, it has been reported that high levels of testosterone contribute to the pathogenesis of PCOS and repression of its excessive production by SeNPs administration may have beneficial effects on PCOS disturbances [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have demonstrated that Se and SeNPs improve insulin resistance in PCOS women and rat models [ 23 , 24 ]. Nevertheless, the effect of SeNPs on androgen production in PCO models has not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Selenium Nanoparticles Modulate Steroidogenesis-Related Genes and Improve Ovarian Functions via Regulating Androgen Receptors Expression in Polycystic Ovary Syndrome Rat Model

Abdallah

El-Ghannam

Hasan

et al. 2023

Biol Trace Elem Res

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) occurs during the reproductive period in women and is characterized by reproductive, endocrine, and metabolic disorders. Androgen plays a decisive role in its pathogenesis due to the interaction between hyperandrogenism and insulin resistance, which might be improved by selenium nanoparticles (SeNPs). The present study aimed to clarify the effect of SeNPs on androgen synthesis and action in the PCOS model and the resulting effect on ovarian function. Fifty-five 7-week-old female albino rats (90–105 g) were divided equally into five groups: control (C), fed a standard diet for 11 weeks; high-fat diet (HFD) group, fed HFD for 11 weeks; HFD and letrozole (L) (HFD + L), fed HFD for 11 weeks and administrated orally with L, at a daily dose of 1 mg/kg BW, for three weeks from the 7th to 9th week of the trial; HFD + L + 0.1SeNPs and HFD + L + 0.2SeNPs groups, treated the same as HFD + L group and orally gavaged SeNPs at daily doses of 0.1 and 0.2 mg/kg BW, respectively, during the last 14 day of the experiment. Daily determination of estrous cycle was performed, and at the end of the experimental period, BMI, serum glucose, insulin, HOMA-IR, lipid profile, sex hormones, TNF-α, IL6, oxidative stress biomarkers, ovarian mRNA expression of different proteins and enzymes involved in steroidogenesis, pathological examination, and immunohistochemical staining for androgen receptor (AR) were evaluated. Treatment of SeNPs restored estrous cyclicity, decreased BMI, and insulin resistance, improved dyslipidemia, reduced serum testosterone, and improved ovarian histopathology in PCOS rats. Furthermore, the anti-inflammatory and antioxidant impacts of SeNPs were remarkably noticed. Administration of SeNPs decreased androgen synthesis and expression of ovarian AR protein by decreasing the mRNA expression of STAR, Cyp11A1, Cyp17A1, and HSD17B3 and increasing the expression of Cyp19α1. Conclusively, SeNPs decreased androgen synthesis and blocked the vicious circle initiated by excessive androgen secretion via decreased AR expression. Thus, it may effectively treat PCOS cases by eliminating its reproductive, endocrine, and metabolic dysfunctions.

show abstract

“…No significant change was observed in the serum level of FSH. These results are similar to those reported by Butt et al [ 24 ] and Ryu et al [ 54 ].…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations