Amended Final Report on the Safety Assessment of Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Rice Bran Acid, Oryza Sativa (Rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (Rice) Bran Extract, Oryza Sativa (Rice) Extract, Oryza Sativa (Rice) Germ Powder, Oryza Sativa (Rice) Starch, Oryza Sativa (Rice) Bran, Hydrolyzed Rice Bran Extract Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein1

Abstract

Aim of the present study was to compare antianxiety activity of various extracts of Oats (OA), Rice Bran (RB) and Spinach (SP) which are rich in phenolics mainly flavonoids and possesses excellent antioxidant property. Flavonoids are reported to have effect on central nervous system, mainly in anxiety disorders. The activity of various extracts (petroleum ether and hydroalcoholic) of all the three plants was evaluated at different doses (50, 100, 200 mg/kg of body weight) using EPM model of anxiety. The studies were conducted on swiss albino mice, and the test materials were administered per oral route. Results indicated that out of all the prepared extracts of the three selected plants, hydroalcoholic extract of Spinach (Spinacia oleracea) exhibited maximum and significant effect at 200 mg/kg of body weight, the results were comparable to the standard antianxiety drug diazepam (2 mg/kg p.o.).

Wax‐based delivery systems: Preparation, characterization, and food applications

“…Moreover, CLW has been examined for acute oral toxicity and no toxic effects were seen following the administration of 5 g/kg CLW by rats and no mortalities occurred after 14 days (Anonymous, 1984). The same safety information has also been considered for RBW by FDA and its oral LD 50 was more than 24 g/kg (male mice model; Anonymous, 2006). Furthermore, BW and CRW have also showed beneficial effects on metabolic disorders by reducing adipogenesis in 3T3-L1 cells (Issara, Park, & Park, 2019).…”

Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes

“…Although adding chemical products to daily cosmetics are controversial due to toxicity issues. Besides, rice derived components generally are well-thought-out to be safe and non-allergenic, as well as investigations had reported no irritation when rice components tested on the skin 44 . Nowadays, the safety of natural products is a fascinating topic in these issues 45 .…”