American Chinese Glaucoma Imaging Study: A Comparison of the Optic Disc and Retinal Nerve Fiber Layer in Detecting Glaucomatous Damage

Leung, Christopher Kai-Shun; Medeiros, Felipe A.; Zangwill, Linda M.; Sample, Pamela A.; Bowd, Christopher; Ng, Diana; Cheung, Carol Y.; Lam, Dennis Shun Chiu; Weinreb, Robert N.

doi:10.1167/iovs.06-1332

Cited by 44 publications

(25 citation statements)

References 23 publications

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“…As compression on the axons is relieved by IOP reduction, the axons may recover their normal shape and size, with resultant increase in RNFL thickness without changes in ONH parameters. These findings could be explained by the fact that the RNFL is a more direct measure of the integrity of retinal ganglion cells, in contrast to the neuroretinal rim, which is composed of nerve fiber bundles, glial cells, and connective tissues 21 and could explain the presence of a statistically significant change for RNFL but not for ONH in our series. However, data interpretation deserves high caution because they could be also explained by physics rules.…”

Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 58%

“…Besides, RNFL attained a higher value in the change of visual sensitivity with respect to different levels of structural damage compared with neuroretinal rim measures. 21 The availability of the elements for a correct sample size calculation was limited by the lack of homogenous data on the effect of sudden IOP reduction on RNFL. We assumed that a change of mean RNFL thickness, as occurring between middle and advanced glaucoma, could be clinically significant.…”

Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 99%

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Short-term changes in the optic nerve head and visual field after trabeculectomy

Figus

Lazzeri

Nardi

et al. 2011

Eye

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Aims or Purpose To evaluate short-term changes in optic nerve head topography and visual field induced by surgical reduction of intraocular pressure. Methods A prospective study was performed on 56 eyes of 56 patients with uncontrolled primary open-angle glaucoma despite maximum medical therapy, which underwent trabeculectomy. Optic nerve head evaluations by means of Heidelberg Retina Tomograph, and visual field tests were performed pre-operatively, and at 3 and 6 months after surgery. Differences in intraocular pressure, visual field indices, and Heidelberg Retina Tomograph parameters were evaluated with the t-test for paired data. A linear regression model was calculated to analyze the relationship between intraocular pressure reduction and visual field changes, and optic nerve head changes. Results Mean intraocular pressure decreased from 24.4 ± 5.0 mm Hg to 12.1 ± 3.1 mm Hg (month 3, Po0.001), and 10.6±2.8 mm Hg (month 6, Po0.001) after trabeculectomy. Mean retinal nerve fiber layer thickness (baseline, 0.19±0.034; month 3, 0.24 ± 0.039, P ¼ 0.05; month 6, 0.21 ± 0.037, P ¼ 0.05) showed a statistical significant change compared with baseline values. Conclusions In this 6-months study, a significant increase in retinal nerve fiber layer thickness was detected after glaucoma filtration surgery.

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Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 58%

Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 99%

Short-term changes in the optic nerve head and visual field after trabeculectomy

Figus

Lazzeri

Nardi

et al. 2011

Eye

View full text Add to dashboard Cite

show abstract

“…[16][17][18] A recent study reported that RNFLT with a second order polynomial regression model fit had the highest correlation (R 2 = 0.383) with MD, better than with rim area measured by HRT. 18 Our results are consistent with this study in that RNFLT could be a more sensitive structural parameter to capture visual function loss in glaucoma than global changes in the ONH.…”

Section: Discussionmentioning

confidence: 98%

Comparison of Mean Deviation With AGIS and CIGTS Scores in Association With Structural Parameters in Glaucomatous Eyes

Naka¹,

Kanamori²,

Tatsumi³

et al. 2009

Journal of Glaucoma

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“…The RNFL defect may precede detectable changes on the optic disc and visual field (VF), 11 and RNFL-based assessments have been reported to be superior to optic disc-based assessments for the diagnosis of glaucoma. 12,13 Although both diseases accompany loss of RNFL, the underlying pathophysiologies of the two diseases are different. Structurally, RNFL loss in diabetes shows a relatively low correlation with the corresponding optic disc area compared to glaucoma, in which rim thinning in the optic disc corresponds to RNFL loss.…”

mentioning

confidence: 99%

Characteristics of Retinal Nerve Fiber Layer Defect in Nonglaucomatous Eyes With Type II Diabetes

Jeon

Kwon

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To investigate the characteristics of retinal nerve fiber layer (RNFL) defects associated with type II diabetes.METHODS. Forty nonglaucomatous eyes with type II diabetes and 54 eyes with early open angle glaucoma that exhibited a localized RNFL defect and 42 eyes from age-and sex-matched nondiabetic, nonglaucomatous controls were imaged with red-free fundus photography and optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec). The area under the receiver operating characteristic curves of eyes with diabetes was compared with that of eyes with glaucoma. When an RNFL defect on fundus photographs was identified in the quadrant, clock-hour, temporal-superior-nasal-inferior-temporal (TSNIT), deviation, and thickness maps, it was considered a true detection. RESULTS.In eyes with diabetes, the RNFL defects were located more frequently in the superior hemisphere than they were in those with glaucoma (P < 0.001). The angular locations of RNFL defects in eyes with diabetes (56.1 6 12.78) were significantly farther from the fovea compared with those in glaucoma (44.3 6 17.38; P < 0.001); in addition, the width of RNFL defects in diabetes (5.1 6 2.38) was significantly narrower than those in glaucoma (20.8 6 12.38; P < 0.001). The best parameter discriminating RNFL defects in diabetes from those in glaucoma was width of RNFL defect (0.955), followed by rim area (0.844), and average RNFL (0.791). The thickness map showed a sensitivity (70%) and specificity (69.1%), superior to those of all other maps in eyes with diabetes.CONCLUSIONS. The narrow width and identification of RNFL defect in thickness map obtained with Cirrus HD-OCT seems to be an effective tool for detecting RNFL defects in diabetes.

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American Chinese Glaucoma Imaging Study: A Comparison of the Optic Disc and Retinal Nerve Fiber Layer in Detecting Glaucomatous Damage

Abstract: The RNFL showed a stronger structure-function association and a higher diagnostic sensitivity for glaucoma detection than did the neuroretinal rim.

Cited by 44 publications

References 23 publications

Short-term changes in the optic nerve head and visual field after trabeculectomy

Short-term changes in the optic nerve head and visual field after trabeculectomy

Comparison of Mean Deviation With AGIS and CIGTS Scores in Association With Structural Parameters in Glaucomatous Eyes

Characteristics of Retinal Nerve Fiber Layer Defect in Nonglaucomatous Eyes With Type II Diabetes

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