Amidated pectin-based wafers for econazole buccal delivery: Formulation optimization and antimicrobial efficacy estimation

Mura, Paola; Mennini, Natascia; Kosalec, Ivan; Furlanetto, Sandra; Orlandini, Serena; Jug, Mario

doi:10.1016/j.carbpol.2014.11.065

Cited by 38 publications

(21 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, wafers have been employed as wound healing [16] and buccal [18] drug delivery systems. They can therefore be employed in the delivery of NIC, including composite systems combining two or more polymers [16,17] as demonstrated by Pawar and co-workers [18,19] who reported the use of composite polymeric wafers combining polyox with either carrageenan or sodium alginate in the development of wafers for controlled delivery of drugs to chronic wound sites [18,19].…”

Section: Introductionmentioning

confidence: 99%

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Okeke

Boateng

2016

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Smoking cessation is of current topical interest due to the significant negative health and economic impact in many countries. This study aimed to develop buccal films and wafers comprising HPMC and sodium alginate (SA) for potential use in nicotine replacement therapy via the buccal mucosa, as a cheap but effective alternative to currently used nicotine patch and chewing gum. The formulations were characterised using texture analyser (tensile and hardness, mucoadhesion), scanning electron microscopy, x-ray diffractometry, attenuated total reflection -Fourier transform infrared (ATR-FTIR), differential scanning calorimetry (DSC) and swelling capacity. Drug loaded films and wafers were characterised for content uniformity (HPLC) whilst the drug loaded wafers only were further characterised for in vitro drug dissolution. SA modified and improved the functional properties of HPMC at optimum ratio of HPMC: SA of 1.25 : 0.75. Generally, both films and wafers (blank and drug loaded) were amorphous in nature which impacted on swelling and mucoadhesive performance.HPMC-SA composite wafers showed a porous internal morphology with higher mucoadhesion, swelling index and drug loading capacity compared to the HPMC-SA composite films which were non-porous. The study demonstrates the potential use of composite HPMC-SA wafers in the buccal delivery nicotine.

show abstract

Section: Introductionmentioning

confidence: 99%

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Okeke

Boateng

2016

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

show abstract

“…This apparatus allows the drug release testing under physiological flow rate of the dissolution medium and offers ability to maintain the sink conditions while operating in an open system setup. Besides compendial, some self-made flow through apparatuses were also used [54]. However, the flow through method shows some disadvantages, including instrument cost and set-up, filter clogging, drug adsorption to the apparatus, problems to maintain a constant flow rate and consequent high variability in the results [39].…”

Section: Membrane Diffusion Methodsmentioning

confidence: 99%

In vitro dissolution/release methods for mucosal delivery systems

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…The high relative sensitivity of ALMP to calcium ion concentrations could be linked to the presence of lone electron pair of Nitrogen from the amide groups that could be able to interact with Ca 2+ , but without the strength of the carboxylate interactions. The presence of amide groups in ALMP makes the biopolymer more hydrophobic and consequently the trend to form gels increases producing more resistant 3D architectures in aqueous media [3,21].…”

Section: Pectin Purification and Characterizationmentioning

confidence: 99%

“…Low and medium methoxylated Pecs can make reversible gels in the presence of multivalent cations, while high methoxylated Pecs are forming irreversible gels in presence of solutes (e.g., sugars) under acidic pH [2]. Amidated low methoxylated pectin (ALMP) are advantageous compared to low methoxylated pectins since can make gels in presence of low bivalent ion concentrations, are less sensitive to pH, and enhanced mucoadhesiveness because of the presence of amide groups [3].…”

Section: Introductionmentioning

confidence: 99%

Development of Crystal Violet encapsulation in pectin - Arabic gum gel microspheres

Revuelta

Villalba

Navarro

et al. 2016

Reactive and Functional Polymers

View full text Add to dashboard Cite

Six pectins with 35% to 91% methoxylation degree were purified and characterized to encapsulate Crystal Violet (CV). Amidated low methoxylated pectin (ALMP) was selected based on microsphere morphologies, aqueous solubility, viscosity and the effect of calcium concentration. Pectin microspheres were stabilized with Arabic gum (AG) and optimized according to the loading. Microspheres composed of 2.0% ALMP-1.0% AG crosslinked with 450 mM calcium(II) were able to encapsulate 217 ± 2 μM CV. Optical microscopy of the gels revealed spheroid microspheres with 250 ± 50 μm diameter containing homogenous CV distribution. Dried microspheres observed by SEM and epifluorescence showed a highly shrinkable matrix keeping the spheroidal morphology. Low relative viscosity of the ALMP-AG-CV solutions was found compared to ALMP and ALMP-AG. The Young moduli (60-80 Pa) of ALMP-AG microspheres by texturometric analysis indicated that the CV could interfere with the gel crosslinking. Raman spectroscopy analysis suggested some interaction of CV nucleophilic center within the matrix. FTIR of the matrix showed largest shifts in the carbonyl and carboxylate groups probably associated to H-bridges. CV stability studies performed on ALMP-AG microspheres, synthetized from polymer solutions with pH values above and below pectin pKa and showed faster CV release rates in presence of ionic strength.

show abstract

Amidated pectin-based wafers for econazole buccal delivery: Formulation optimization and antimicrobial efficacy estimation

Cited by 38 publications

References 36 publications

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

In vitro dissolution/release methods for mucosal delivery systems

Development of Crystal Violet encapsulation in pectin - Arabic gum gel microspheres

Contact Info

Product

Resources

About