Amide proton transfer imaging in differentiation of type II and type I endometrial carcinoma: a pilot study

Ochiai, Ryoya; Mukuda, Naoko; Yunaga, Hiroto; Kitao, Shinichiro; Okuda, K; Sato, Shinya; Oishi, Tsutomu; Miyoshi, Mitsuharu; Nozaki, Atsushi; Fujii, Shinya

doi:10.1007/s11604-021-01197-3

Cited by 13 publications

(7 citation statements)

References 27 publications

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“…Amide proton transfer‐weighted (APTw) imaging is a magnetic resonance molecular‐imaging technique based on the chemical exchange saturation transfer phenomenon, 15 and it has been applied to the diagnosis of EC, together with the pathological features and immunohistochemical indicators (Ki‐67). Ochiai et al 16 reported that the APT value of type II EC was higher than that of type I EC. Takayama et al 17 found that the APT value was positively correlated with the histological grade of endometrioid adenocarcinoma.…”

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confidence: 97%

Amide Proton Transfer‐Weighted Imaging Combined With Intravoxel Incoherent Motion for Evaluating Microsatellite Instability in Endometrial Cancer

Song

et al. 2022

Magnetic Resonance Imaging

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Background Microsatellite instability (MSI), caused by mismatch repair (MMR) protein defects that lead to uncorrectable mismatch bases, results in the accumulation of gene mutations and ultimately to tumors. Preoperative prediction of MSI can provide a basis for personalized and precise treatment of endometrial cancer (EC) patients. Purpose To investigate amide proton transfer weighting (APTw) imaging combined with intravoxel incoherent motion (IVIM) in the assessment of MSI in EC. Study Type Retrospective. Population A total of 71 patients with EC (12 classified as the MSI group and 22 as the microsatellite stabilization [MSS] group after entering and leaving the group standard). Field Strength/Sequence A 3.0 T/IVIM, diffusion‐weighted imaging (DWI) and APTw. Assessment Amide proton transfer (APT) value, apparent diffusion coefficient (ADC), pure diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) were calculated and compared between MSI and MSS groups. Statistical Tests The Kendall's W test; Mann–Whitney U‐test; Chi‐square test or Fisher's exact test; logistic regression analysis; Area under the receiver operating characteristic (ROC) curve (AUC); The Delong test; Pearson or Spearman correlation coefficients. The significance threshold was set at P < 0.05. Results APT and D* values of the MSI group were significantly higher than those of the MSS group. While ADC, D, and f values in the MSI group were significantly lower than those in the MSS group. The multivariate analysis revealed that only APT and D* values were independent predictors to evaluate the MSI status. And the ROC curves indicated that the combination of APT and D* values could distinguish the MSI status of EC with the highest diagnostic efficacy (AUC = 0.973), even without significant difference to those by APT (AUC = 0.894) or D* (AUC = 0.920) value separately (P = 0.149 and 0.078, respectively). Conclusion Combination of APTw and IVIM imaging may serve as an effective noninvasive method for clinical assessment of MSI in EC. Evidence Level 3 Technical Efficacy Stage 2

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confidence: 97%

Amide Proton Transfer‐Weighted Imaging Combined With Intravoxel Incoherent Motion for Evaluating Microsatellite Instability in Endometrial Cancer

Song

et al. 2022

Magnetic Resonance Imaging

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“…A total of five groups have contributed reports that were involving cervical cancer and endometrial carcinomas along with healthy uterine tissues. APT values changed with cancer type [ 56 ], histology grade [ 60 ], proliferation, as well as menstrual cycle. The APT method was co-studied with other fMRI methods [ 57 ].…”

Section: Applicationsmentioning

confidence: 99%

“…Ochiai et al [ 56 ] evaluated the efficacy of APT imaging in the differentiation of type I and type II uterine endometrial carcinoma in a 33-patient study. Results show that APT imaging has the potential to determine the type of endometrial cancer.…”

Section: Applicationsmentioning

confidence: 99%

A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging

Gao

Zou

et al. 2021

IJMS

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Chemical exchange saturation transfer (CEST) MRI is a promising molecular imaging tool which allows the specific detection of metabolites that contain exchangeable amide, amine, and hydroxyl protons. Decades of development have progressed CEST imaging from an initial concept to a clinical imaging tool that is used to assess tumor metabolism. The first translation efforts involved brain imaging, but this has now progressed to imaging other body tissues. In this review, we summarize studies using CEST MRI to image a range of tumor types, including breast cancer, pelvic tumors, digestive tumors, and lung cancer. Approximately two thirds of the published studies involved breast or pelvic tumors which are sites that are less affected by body motion. Most studies conclude that CEST shows good potential for the differentiation of malignant from benign lesions with a number of reports now extending to compare different histological classifications along with the effects of anti-cancer treatments. Despite CEST being a unique ‘label-free’ approach with a higher sensitivity than MR spectroscopy, there are still some obstacles for implementing its clinical use. Future research is now focused on overcoming these challenges. Vigorous ongoing development and further clinical trials are expected to see CEST technology become more widely implemented as a mainstream imaging technology.

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“…Previous data suggested that, due to over-expressed mobile protein and peptide concentrations, APTw can assess the pathological grade of malignant tissue. For example, a previous study found that histologically type II, high-grade, high International Federation of Gynecology and Obstetrics (FIGO) stage and lymphovascular space invasion (LVSI)-positive EC have higher APT values (14,15). In addition, Li et al (16) showed that the APT value was moderately positively correlated with the expression index of the nuclear antigen Ki-67 associated with EC cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma

Shifeng,

Yue,

Wen

et al. 2023

Acta Radiol

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Background Endometrial carcinoma (EC) is the sixth most common cancer in women. P53 gene expression in patients with endometrial cancer can predict the efficacy and prognosis of patients with neoadjuvant therapy. Purpose To explore the value of multimodal magnetic resonance imaging (MRI) in differentiating p53 abnormal (p53abn) from p53 wild-type (p53wt) EC. Material and Methods Data from 47 EC patients, including 14 p53abn cases and 33 p53wt cases, were retrospectively analyzed. The preoperative MRI sequences included amide proton transfer weighted (APTw) imaging, T2 mapping, mDIXON-Quant imaging and diffusion-weighted imaging (DWI). After post-processing, APT, T2, transverse relaxation rate (R2*), fat fraction (FF) and apparent diffusion coefficient (ADC) maps were obtained. The APT, T2, R2*, FF and ADC values for lesions of the two groups of cases were measured by two observers who were blind to the pathological data. Results The APT value and R2* value in the p53abn group were higher than those in the p53wt group, while the ADC value was lower (all P < 0.05). There was no statistically significant difference in T2 value and FF value between the two groups (all P > 0.05). The area under curve of APT, R2*, ADC and combined APT + R2*+ADC values for identification of p53abn and p53wt EC were 0.739, 0.689, 0.718 and 0.820, respectively (all P > 0.05). Conclusion APTw, mDIXON-Quant and DWI techniques can be usedfor quantitative identification of p53abn and p53wt EC. The multimodal MRI provides a new way for preoperative quantitative evaluation of EC molecular typing, which has certain clinical application value.

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Amide proton transfer imaging in differentiation of type II and type I endometrial carcinoma: a pilot study

Cited by 13 publications

References 27 publications

Amide Proton Transfer‐Weighted Imaging Combined With Intravoxel Incoherent Motion for Evaluating Microsatellite Instability in Endometrial Cancer

Amide Proton Transfer‐Weighted Imaging Combined With Intravoxel Incoherent Motion for Evaluating Microsatellite Instability in Endometrial Cancer

A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging

The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma

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