2014
DOI: 10.1007/s00210-014-1004-2
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Amide-type local anesthetics action on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle

Abstract: Myotoxic effects related to intracellular Ca(2+) disturbances have been reported for local anesthetics. Such effects might derive from Ca-ATPase dysfunction. The aim of this work was to describe the effect of lidocaine and bupivacaine on the sarcoplasmic reticulum (SR) Ca-ATPase from fast-twitch skeletal muscle and to identify the affected steps of the enzyme's cycle. SR sealed vesicles were isolated from rabbit fast-twitch muscles by ultracentrifugation. The effect of the anesthetics on Ca-ATPase activity was… Show more

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Cited by 5 publications
(2 citation statements)
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“…It is possible that the myonecrosis arising from bupivacaine promotes sarcolemmal injury, allowing excessive entry of calcium. This ion leads to hypercontraction of myofibrils [27,54,55], increasing the quantity of intracellular free radicals due to the generation of oxidative stress, culminating in mitochondrial degeneration [39]. Considering that proteins in the synaptic region are transmembranic, alterations in the plasma membrane of the fiber and its sarcoplasm directly affect the muscle synapse [21], such that alterations in the NMJs can be considered responses to the pathological process of myonecrosis [29].…”
Section: Discussionmentioning
confidence: 99%
“…It is possible that the myonecrosis arising from bupivacaine promotes sarcolemmal injury, allowing excessive entry of calcium. This ion leads to hypercontraction of myofibrils [27,54,55], increasing the quantity of intracellular free radicals due to the generation of oxidative stress, culminating in mitochondrial degeneration [39]. Considering that proteins in the synaptic region are transmembranic, alterations in the plasma membrane of the fiber and its sarcoplasm directly affect the muscle synapse [21], such that alterations in the NMJs can be considered responses to the pathological process of myonecrosis [29].…”
Section: Discussionmentioning
confidence: 99%
“…15,30,33e38,41,43 These mechanisms are thought to be related to LA interference with ATP phosphorylation. 37,41,43 A surge in myoblastic apoptosis is the sequela of LA exposure. 1,19e23,25e29 Apoptosis is triggered by increased Back muscles, 37 back leg muscles, 43 breast muscle, 28 C2C12 cell line, 18e23,25,26 oesophageal muscle, 24 extensor digitorum longus muscle, 1,24,35,36 first lumbrical of foot muscle, 27 flexor digitorum brevis muscle, 24 hind leg muscles 15,32,33,42 masseter muscle, 34,37,41 medial pterygoid, 37,38,41 psoas muscle 40 quadriceps muscle, 29 skeletal muscle, 13,30,31 soleus muscle, 1,24 temporalis muscle, 39 tibialis anterior muscle 1 Humans, 13,29 mice, 1,18e26,35,36 quail, 28 rats, 27 pigs, 42 rabbits 15,30e34,37e41,43 Articaine, 38 benzocaine, 32 bupivacaine, 1,13,18e21,23e29,34,35,41e43 bupivacaine S and R enantiomers, 35,36 bupivacaine with caffeine, 1 bupivacaine with dantrolene...…”
Section: Myotoxic Damagementioning
confidence: 99%