Amides from the Stem Bark of<i>Fagara macrophylla</i>

Wansi, Jean Duplex; Nwozo, Sarah Onyenibe; Mbaze, Luc Meva’a; Devkota, Krishna Prasad; Moladje, Suzye Mireille Donkwe; Fomum, Zacharias Tanee; Sewald, Norbert

doi:10.1055/s-0029-1185327

Cited by 19 publications

(10 citation statements)

References 11 publications

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“…The potential of Z. species in the treatment of cancer has been assessed using both drug-sensitive and drug-resistant cancer cells. For example, antiproliferative activities have been demonstrated using cell culture studies for extracts of Z. clava-herculis L. stem bark against lung cancer (A549) ( Wansi et al, 2009 ), Z. ailanthoides Seibold. and Zucc.…”

Section: Zanthoxylum Species As Potential Sources Of Anticancer Agentsmentioning

confidence: 99%

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

et al. 2021

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The health benefits and toxicity of plant products are largely dependent on their secondary metabolite contents. These compounds are biosynthesized by plants as protection mechanisms against environmental factors and infectious agents. This review discusses the traditional uses, phytochemical constituents and health benefits of plant species in genus Zanthoxylum with a focus on cancer, microbial and parasitic infections, and sickle cell disease as reported in articles published from 1970 to 2021 in peer-reviewed journals and indexed in major scientific databases. Generally, Z. species are widely distributed in Asia, America and Africa, where they are used as food and for disease treatment. Several compounds belonging to alkaloids, flavonoids, terpenoids, and lignans, among others have been isolated from Z. species. This review discusses the biological activities reported for the plant species and their phytochemicals, including anticancer, antibacterial, antifungal, antiviral, anti-trypanosomal, antimalarial and anti-sickling properties. The safety profiles and suggestions for conservation of the Z. species were also discussed. Taken together, this review demonstrates that Z. species are rich in a wide range of bioactive phytochemicals with multiple health benefits, but more research is needed towards their practical application in the development of functional foods, nutraceuticals and lead compounds for new drugs.

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Section: Zanthoxylum Species As Potential Sources Of Anticancer Agentsmentioning

confidence: 99%

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

et al. 2021

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“… Dischistocalyx grandifolius C.B.Clarke (Acanthaceae) 27646/SRF Cam; Mbouda Whole plant (whole plant: 4.53 %) Infectious diseases [ 50 ] Not reported Not reported Fagara macrophylla Engl. (Rutaceae) 6173/SRF Cam; Mbouda Bark, leaves and seeds (bark: 8.43 %; leaves: 6.81 %) Hypertension [ 51 ], colds and stomach-ache, fever, malaria [ 50 ], cancers [ 52 ] Alkaloids: tembetarineoblongine, magnoflorine, arborinine, nitidine, dihydronitidine, xanthoxoline, 1-Hydroxy-3-methoxy-N-methyl-acridone, N -(4 hydroxyphenethyl)octacosanamide, N -(4-hydroxyphenethyl)hexacosanamide, N -(4-hydroxyphenethyl)decanamide, N -vanilloyltyramine, and N -[ O -docosanoylvanilloyl]tyramine, flavonoid: hesperidin [ 53 – 56 ] Antiplasmodial :bark [ 55 ]; Antifeedant: xanthoxoline and 1-hydroxy-3-methoxy-N-methyl-acridone, arborinine, tembetarine and magnoflorine against Spodoptera frugiperda , S. littoralis and S. frugiperda [ 54 ]; Low cytotoxicity: seeds extract towards leukemia CCRF-CEM and CEM/ADR5000 cells lines and pancreatic cancer MiaPaCa-2 cell line [ 52 ]; Antitumor: nitidine chloride and 6-methoxy-5,6-dihydronitidine [ 57 ] Myrianthus arboreus P.Beauv. (Moraceae) 55499/HNC; Bangangté Bark, leaves (bark: 7.68 %; leaves: 10.37 %) Dysentery, diarrhea, vomiting, analgesic, antipyretic, heart troubles, pregnancy complications, dysmenorrheal, incipient hernia, boils, toothache, bronchitis, sore throat [ 58 ]; headaches, swellings and tumours, diabetes [ 40 ]; stomach disorders [ 59 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of selected Cameroonian medicinal plants and Nauclea pobeguinii towards multi-factorial drug-resistant cancer cells

Kuete

Sandjo

Mbaveng

et al. 2015

BMC Complement Altern Med

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BackgroundMalignacies are still a major public concern worldwide and despite the intensive search for new chemotherapeutic agents, treatment still remains a challenging issue. This work was designed to assess the cytotoxicity of six selected Cameroonian medicinal plants, including Nauclea pobeguinii and its constituents 3-acetoxy-11-oxo-urs-12-ene (1), p-coumaric acid (2), citric acid trimethyl ester (3), resveratrol (4), resveratrol β-D-glucopyranoside (5) and strictosamide (6), against 8 drug-sensitive and multidrug-resistant (MDR) cancer cell lines.MethodsThe resazurin reduction assay was used to evaluate the cytotoxicity of the crude extracts and compounds, whilst column chromatography was used to isolate the constituents of Nauclea pobeguinii. Structural characterization of isolated compounds was performed using nuclear magnetic resonance (NMR) spectroscopic data.ResultsPreliminary experiments on leukemia CCRF-CEM cells at 40 μg/mL showed that the leaves and bark extracts from Tragia benthamii, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Fagara macrophylla induced more than 50 % growth of this cell line contrary to the leaves and bark extracts of N. pobeguinii. IC50 values below or around 30 μg/mL were obtained with leaves and bark extracts of N. pobeguinii towards two and five, respectively, of the 8 tested cancer cell lines. The lowest IC50 value was obtained with the bark extract of N. pobeguinii against HCT116 (p53−/−) colon cancer cells (8.70 μg/mL). Compounds 4 and 6 displayed selective activity on leukemia and carcinoma cells, whilst 1–3 were not active. IC50 values below 100 μM were recorded with compound 5 on all 9 tested cancer cell lines as well as with 4 against 7 out of 8 and 6 against 2 out of 8 cell lines.Collateral sensitivity was observed in CEM/ADR5000 leukemia cells, MDA-MB-231-BCRP breast adenocarcinoma cells (0.53-fold), HCT116 (p53+/+) cells, human U87MG.ΔEGFR glioblastome multiforme cells to the methanolic bark extract of N. pobeguinii, as well as in MDA-MB-231-BCRP cells and HCT116 (p53+/+) cells and U87MG.ΔEGFR cells (0.86-fold) to compound 5.ConclusionsThe results of this study demonstrate the cytotoxicity of six Cameroonian medicinal plants, Canarium schweinfurthii, Dischistocalyx grandifolius, Tragia benthamii, Fagara macrophylla, Myrianthus arboreus and Nauclea pobeguinii. We also demonstrated the antiproliferative potential of Nauclea pobeguinii against drug-resistant cancer cell lines. Resveratrol and its glucoside are the major cytotoxic constituents in the bark of Nauclea pobeguinii.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-015-0841-y) contains supplementary material, which is available to authorized users.

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“…Engl. (Rutaceae) 6173/SRFC-Cam Leaves (6.81 %) Bark (8.43 %) Bamboutos Mountain, West region of Cameroon Malaria (Zirihi et al 2007 ); hypertension (Fézan et al 2008 ) Alkaloids: tembetarine,oblongine, magnoflorine, arborinine, nitidine (Torto and Mensah 1970 ; Tringali et al 2001 ); dihydronitidine (Zirihi et al 2007 ); acridone alkaloid and amide alkaloids (Wansi et al 2009 ); flavonoid: hesperidin (Tringali et al 2001 ) Antiplasmodial activities of ethanol bark extracts (Zirihi et al 2007 ); antifeedant activities of isolated acridone alkaloid, arborinine, tembetarine and magnoflorine against SF , SL, SFr (Tringali et al 2001 ) Myrianthus arboreus P. Beauv. (Moraceae) 55499/HNC Bark (7.68 %) Leaves (10.37 %) Bangangté, West Region of Cameroon Dysentery, diarrhea,vomiting; analgesic, antipyretic, heart troubles, pregnancy complications, dysmenorrheal, incipient hernia, boils, toothache, bronchitis, sore throat; headaches, swellings and tumours, diabete (Orwa et al 2009 );stomach disorders (Agwa et al 2011 ; Uzodimma 2013 ) Alkaloids, flavonoid, tannin (Orwa et al 2009 ); cyanogenic glycosides, phytic acid (Agwa et al 2011 ); terpenes (Borokini and Omotayo 2012 ); saponin, anthocyanin, glycoside, carotenoid, oxalate (Otitoju et al 2014 ) Antibacterial activities of methanol and aqueous extracts against KP, PV, SA, EC (Agwa et al 2011 ); antiplasmodial activities by inhibiting the developmental stage of AG (Akinkurolere et al 2011 ) Tragia benthamii Bak.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria

2015

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Bacterial infections caused by multidrug resistant phenotypes constitute a worldwide health concern. The present study was designed to evaluate the in vitro antibacterial activities of the methanol extracts of five medicinal plants: Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against a panel of 28 multidrug resistant Gram-negative bacterial strains. The liquid broth microdilution was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts. The best activity was recorded with Canarium schweinfurthii bark extract, MIC values ranging from 32 to 1024 µg/mL being recorded against 85.7 % tested bacteria. Broad spectra of antibacterial activities were also obtained with both bark and leaf extracts from Myrianthus arboreus (78.6 %) as well as the bark extract from Fagara macrophylla (75.0 %). The lowest MIC value of 32 µg/mL was obtained with Canarium schweinfurthii bark extract against Klebsiella pneumoniae KP63 strain. The results of this work provide baseline information for the use of the studied plants, and mostly Fagara macrophylla, Canarium schweinfurthii and Myrianthus arboreus in the treatment of bacterial infections including multidrug resistant phenotypes.

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Amides from the Stem Bark ofFagara macrophylla

Cited by 19 publications

References 11 publications

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

Cytotoxicity of selected Cameroonian medicinal plants and Nauclea pobeguinii towards multi-factorial drug-resistant cancer cells

Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria

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