Amine-functionalized mesoporous silica KIT-6 as a controlled release drug delivery carrier

Ayad, Mohamad M.; Salahuddin, Nehal; El-Nasr, Ahmed Abu; Torad, Nagy L.

doi:10.1016/j.micromeso.2016.04.029

Cited by 75 publications

(48 citation statements)

References 65 publications

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“…This shows that the sample has a highly ordered mesostructure with a 3D cubic Ia3d symmetry. The XRD pattern of the sample synthesized in current project is similar to the XRD pattern for KIT-6 reported by Ayad [13]. Figure 3 shows the FTIR spectrum of KIT-6.…”

Section: Membrane Characterizationsupporting

confidence: 76%

Preparation of mixed matrix membrane using cellulose acetate incorporated with synthesized KIT-6 silica

Ding¹,

Chew²,

Oh³

et al. 2018

J. MECH. ENG. SCI.

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There is increasing interest among researchers to develop Mixed Matrix Membranes (MMMs), by incorporating fillers in polymer membranes. However, these membranes always suffer from a trade-off between permeability and selectivity as proven by Robeson in upper bound curves developed in gas separation applications. In current project, mesoporous silica, KIT-6 was synthesized and followed by incorporation of KIT-6 as filler into cellulose acetate (CA) matrix to form MMMs. The fabrications of MMMs were done by using dry phase inversion method. The KIT-6 loadings in the MMMs were varied from 2 to 10 wt%. The properties of KIT-6 and membranes were characterized with Scanning electron microscopy (SEM), Fourier transform infrared (FTIR), X-ray diffraction (XRD) and thermal gravimetric analysis (TGA). The effect of KIT-6 loadings on the properties of the formed MMMs was investigated. XRD and FTIR results suggested that KIT-6 mesoporous silica is successfully synthesized. The TGA curve indicate the overall weight loss of 3.02 % for KIT-6 and 72.29-86.77 % for all the membranes. The successful incorporation of silica particles into CA polymer matrix is confirmed by FTIR spectrum while MMMs images from SEM suggested that KIT-6 silica powder could embed well with CA polymer matrix. Defect-free MMMs could be fabricated and potential to be use in future especially in gas separation.

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Section: Membrane Characterizationsupporting

confidence: 76%

Preparation of mixed matrix membrane using cellulose acetate incorporated with synthesized KIT-6 silica

Ding¹,

Chew²,

Oh³

et al. 2018

J. MECH. ENG. SCI.

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“…For both CUR and CPT, the DLC found were in the range of 0.4–0.7 %, and DLE in the range of 4–6.4 % (see experiment table assays in Table S1). Standard MSNs loaded with various hydrophobic anticancer drugs have been reported, including Camptothecin, 5‐Fluorouracile, Paclitaxel, Docetaxel, and Curcumin with DLCs of a few percent, mainly between 0.06 and 2.4 %, which in fact are standard values for the loading of hydrophobic molecules in MS nanosystems . Furthermore, to afford a biocompatible HSA coating, the drug loaded CNT@MS‐IBAM composites, after removal of the drug supernatant, were brought in contact with a solution of HSA (at 0.25 mg mL −1 ).…”

Section: Resultsmentioning

confidence: 99%

Design of Protein‐Coated Carbon Nanotubes Loaded with Hydrophobic Drugs through Sacrificial Templating of Mesoporous Silica Shells

Fiegel

Harlepp

Bégin

et al. 2018

Chemistry A European J

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One key challenge in the fields of nanomedicine and tissue engineering is the design of theranostic nanoplatforms able to monitor their therapeutic effect by imaging. Among current developed nano-objects, carbon nanotubes (CNTs) were found suitable to combine imaging, photothermal therapy, and to be loaded with hydrophobic drugs. However, a main problem is their resulting low hydrophilicity. To face this problem, an innovative method is developed here, which consists in loading the surface of carbon nanotubes (CNTs) with drugs followed by a protein coating around them. The originality of this method relies on first covering CNTs with a sacrificial template mesoporous silica (MS) shell grafted with isobutyramide (IBAM) binders on which a protein nanofilm is strongly adhered through IBAM-mediated physical cross-linking. This concept is first demonstrated without drugs, and is further improved with the suitable loading of hydrophobic drugs, curcumin (CUR) and camptothecin (CPT), which are retained between the CNTs and human serum albumin (HSA) layer. Such novel nanocomposites with favorable photothermal properties are very promising for theranostic systems, drug delivery, and phototherapy applications.

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“…The MSN-40/CTAB has significant weight loss due to surfactant CTAB loss of MSN-40/CTAB at 100-500 ∘ C. For amine functionalized samples, the TG curves have a rapid weight loss at 200-800 ∘ C, which is due to the removal of multiamine groups [21]. This is significant evidence of the existence of amine groups on the surface and inner pore of MSN-40 [21,38,39]. The MSN-DQ-40 can be further confirmed due to fairly obvious weight loss compared to MSN-NH 2 -40.…”

Section: Releasing Of Ibumentioning

confidence: 99%

Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release

Song

Guo

et al. 2018

Journal of Nanomaterials

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Mesoporous silica spheres were synthesized by using Stöber theory . Calcination of the mesostructured phase resulted in the starting solid. Organic modification with aminopropyl groups resulted in two MSN-40 materials: named MSN-NH 2 and MSN-DQ-40, respectively. These two kinds of samples with different pore sizes (obtained from 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethox-ysilane (NQ-62) and modified NQ-62) showed control of the delivery rate of ibuprofen (IBU) from the siliceous matrix. The obtained sample from modified NQ-62 has an increased loading rate and shows better control of the delivery rate of IBU than the obtained sample from NQ-62. These three solids were characterized using standard solid state procedures. During tests of in vitro drug release, an interesting phenomenon was observed: at high pH (pH 7.45), IBU in all carriers was released slowly; at low pH (pH 4.5), only a part of the IBU was slowly released from this carrier within 25 hours; most IBU was effectively confined in mesoporous material, but the remaining IBU was released rapidly and completely after 25 hours.

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Amine-functionalized mesoporous silica KIT-6 as a controlled release drug delivery carrier

Cited by 75 publications

References 65 publications

Preparation of mixed matrix membrane using cellulose acetate incorporated with synthesized KIT-6 silica

Preparation of mixed matrix membrane using cellulose acetate incorporated with synthesized KIT-6 silica

Design of Protein‐Coated Carbon Nanotubes Loaded with Hydrophobic Drugs through Sacrificial Templating of Mesoporous Silica Shells

Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release

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