Amine‐Terminated Ionic Liquid Modified Magnetic Graphene Oxide (MGO‐IL‐NH₂): A Highly Efficient and Reusable Nanocatalyst for the Synthesis of 3‐Amino Alkylated Indoles

Abstract

Amine‐terminated ionic liquid has been covalently fabricated over the surface of Magnetic graphene oxide nanosheets. The structure of prepared material has been confirmed by various characterization techniques such as Fourier Transform Infrared Spectroscopy (FT‐IR), Powder XRD, Vibrating Sample Magnetometer (VSM), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Energy Dispersive X‐ray spectroscopy (EDX). The prepared material demonstrates its supremacy as an efficient, recyclable and cost‐effective heterogeneous catalyst in the synthesis of 3‐amino alkylated indoles via Mannich reaction. The presence of both the hydrogen‐bond donors and acceptors assemblies helps to activate the substrate molecule, thereby increases the rate of reaction and excellent product yields have been obtained. Moreover, the catalyst could be magnetically recovered and recyclable up to seven consecutive cycles thereby make the protocol efficient for large‐scale production of pharmaceutically important compounds.

Reusable Nano Catalysed Synthesis of Heterocycles: An Overview

“…Additionally, the catalyst is retrieved using an external magnet, and a recyclability test revealed that the catalyst may be reused up to seven times without losing its catalytic efficiency (Scheme 23, Table 15). [31]…”

Recent Advances in Ionic Liquids and Ionic Liquid-Functionalized Graphene: Catalytic Application and Environmental Remediation

“…The resulting magnetic graphene oxide (MGO) was functionalized with imidazole by the reaction of MGO with 3-chloropropyltrimeth-oxysilane followed by N-alkylation of imidazolium salt. Finally, the quaternization of the resultant product was achieved by the reaction of the resultant with 2-chloroethylamine in order to obtain the final magnetic graphene oxide-supported amine-functionalized IL (MGO−IL−NH 2 ) ( Figure 1 ) [ 10 ].…”

Studying the Structure and Properties of Epoxy Composites Modified by Original and Functionalized with Hexamethylenediamine by Electrochemically Synthesized Graphene Oxide

“…One of the ways to change the functional properties of GO is covalent or non-covalent modification of GO [3][4][5], which is essential for the creation of various composite materials [6,7]. Interest in the derivatization of GO stems from the wide possibilities of regulating the chemical and physical properties of the material which are due to the addition of a certain amount of both organic functional groups on the basal plane and on the edge sections of GO and of inorganic compounds [8][9][10][11]. There has been growing interest in the modification of organic structures containing an amino group, especially aliphatic and/or aromatic amines, to change the structure of the GO surface [12][13][14].…”