Amino-functionalized polymers by gamma radiation and their influence on macrophage polarization

Pérez-Calixto, Mitzi; Díaz‐Rodríguez, Patricia; Concheiro, Ángel; Burillo, Guillermina

doi:10.1016/j.reactfunctpolym.2020.104568

Cited by 10 publications

(8 citation statements)

References 37 publications

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“…Fibroblasts are adherent cells; thus, they need to be attached to a surface to function, therefore the fact that they survived in solution is a good sign. In comparison to other studies in which lower cytocompatibilities have been found, the cytocompatibility of these materials is acceptable [ 70 ].…”

Section: Resultsmentioning

confidence: 69%

Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility

et al. 2021

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The modification of medical devices is an area that has attracted a lot of attention in recent years; particularly, those developments which search to modify existing devices to render them antimicrobial. Most of these modifications involve at least two stages (modification of the base material with a polymer graft and immobilization of an antimicrobial agent) which are both time-consuming and complicate synthetic procedures; therefore, as an improvement, this project sought to produce antimicrobial silicone (PDMS) in a single step. Using gamma radiation as both an energy source for polymerization initiation and as a source of reducing agents in solution, PDMS was simultaneously grafted with acrylic acid and ethylene glycol dimethacrylate (AAc:EGDMA) while producing antimicrobial silver nanoparticles (AgNPs) onto the surface of the material. To obtain reproducible materials, experimental variables such as the effect of the dose, the intensity of radiation, and the concentration of the silver salt were evaluated, finding the optimal reaction conditions to obtain materials with valuable properties. The characterization of the material was performed using electronic microscopy and spectroscopic techniques such as 13C-CPMAS-SS-NMR and FTIR. Finally, these materials demonstrated good antimicrobial activity against S. aureus while retaining good cell viabilities (above 90%) for fibroblasts BALB/3T3.

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Section: Resultsmentioning

confidence: 69%

Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility

et al. 2021

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“…Simulation methods discussed in this review can be applied to modeling of a wider class of physical processes in polymer matrices in the presence of light illumination like, e.g., developing of polymer-based materials by UV-Vis and gamma radiations, using UV cross linking [ 225 , 226 , 227 ], gamma sterilization [ 228 ], gamma functionalization [ 229 ] and surface modification [ 230 ]. Another interesting area of applications is related to the effects of photo-ordering in azo-polymers irradiated with high-energy ions.…”

Section: Discussionmentioning

confidence: 99%

Modeling of Nonlinear Optical Phenomena in Host-Guest Systems Using Bond Fluctuation Monte Carlo Model: A Review

et al. 2021

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We review the results of Monte Carlo studies of chosen nonlinear optical effects in host-guest systems, using methods based on the bond-fluctuation model (BFM) for a polymer matrix. In particular, we simulate the inscription of various types of diffraction gratings in degenerate two wave mixing (DTWM) experiments (surface relief gratings (SRG), gratings in polymers doped with azo-dye molecules and gratings in biopolymers), poling effects (electric field poling of dipolar molecules and all-optical poling) and photomechanical effect. All these processes are characterized in terms of parameters measured in experiments, such as diffraction efficiency, nonlinear susceptibilities, density profiles or loading parameters. Local free volume in the BFM matrix, characterized by probabilistic distributions and correlation functions, displays a complex mosaic-like structure of scale-free clusters, which are thought to be responsible for heterogeneous dynamics of nonlinear optical processes. The photoinduced dynamics of single azopolymer chains, studied in two and three dimensions, displays complex sub-diffusive, diffusive and super-diffusive dynamical regimes. A directly related mathematical model of SRG inscription, based on the continuous time random walk (CTRW) formalism, is formulated and studied. Theoretical part of the review is devoted to the justification of the a priori assumptions made in the BFM modeling of photoinduced motion of the azo-polymer chains.

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“…The selfassembly can be formed by a simple dip coating or a chemical vapour deposition [29,[47][48][49]. In another study, polypropylene (PP) and polytetrafluoroethylene (PTFE) films were functionalized by amine groups in two steps; first grafting of acryloyl chloride (AC) using γ-rays and then chemical coupling between the grafted AC and ethylenediamine (ED) as shown in Figure 4(b) [50,51]. Another group grafted primary amine on PP surface by first grafting acrylamide through γ radiation followed by its vinylamine using sodium hypochlorite and sodium thiosulfate [52,53].…”

Section: Strategies Of the Surface Engineering/ Modificationmentioning

confidence: 99%

Surface engineering of personal protective equipments (PPEs) to prevent the contagious infections of SARS-CoV-2

Pandey

2020

Surface Engineering

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The outermost surfaces of Personal Protective Equipments (PPEs) interact with virus surfaceprotein as the first step during its transmission from aerosols and contacting surfaces, which can be tuned by surface engineering/modification. This report highlights the role of engineered surface chemistry of PPEs to avoid the spreading of the novel SARS-CoV-2 virus in hospitals. Physical properties of surfaces and spike-glycoprotein are correlated with the reported stability of SARS-CoV-2. The spike-protein is reported to be hydrophobic in nature with an isoelectric point of 5.9. Hence surface with both positive charge and hydrophobic groups are expected to achieve a strong binding with the surface spike-protein. Various surface engineering strategies of polypropylene and other materials with hybrid selfassembled monolayers and dopamine are discussed to design the mixed hydrophobic and charged surfaces. The strong surface-protein interactions may lead to severe conformational changes and destabilization of the viral envelope, which can disintegrate and inactivate the novel coronavirus.

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Amino-functionalized polymers by gamma radiation and their influence on macrophage polarization

Cited by 10 publications

References 37 publications

Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility

Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility

Modeling of Nonlinear Optical Phenomena in Host-Guest Systems Using Bond Fluctuation Monte Carlo Model: A Review

Surface engineering of personal protective equipments (PPEs) to prevent the contagious infections of SARS-CoV-2

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