Amino-modified 2-oxazoline copolymers for complexation with DNA

Abstract

Copolymers of 2-isopropyl-2-oxazoline (iPrOx) with 2-methyl-2-oxazoline (MetOx) and 2-(3-butenyl)-2-oxazoline (ButEnOx) were synthesized via cationic ring opening polymerization (CROP). In the next step the copolymers were modified to obtain primary and...

Chelate-functionalized poly(2-oxazoline) for the destruction of bacterial cell membranes

“…For example, in the aqueous solutions of copolymers based on 2-ethyl- and 2- n -propyl-2-oxazoline, both unimers and large aggregates coexist around room temperature. 50 For gradient copolymers of 2-isopropyl-, 2-methyl- and 2-(3-butenyl)-2-oxazoline modified with primary and secondary amine groups in the substituents, 45 as well as for gradient copolymers based on 2- n -propyl- and 2-methyl-2-oxazoline, 51 bi- or even multimodal size distributions at 25 °C were observed. It should be also kept in mind that DLS evaluation of particle size from intensity, used in this work, detects, by nature, large aggregates even at a very low % of total content.…”

“…Synthesis of “POx-NH 2 ”: The modification of vinyl double bonds present in ButEnOx was carried out according to the procedure described in ref. 45. Briefly, POx was dissolved in a THF : methanol 50 : 50 v/v mixture ( c = 50 mg mL −1 ) in a reactor dried under reduced pressure.…”