Aminopterin for Psoriasis

The emergence of supportive oncodermatology: The study of dermatologic adverse events to cancer therapies

“…28 Despite these efforts, there is still a paucity of adequate data supporting the use of other pharmacologic agents, and treatment guidelines are based on anecdotal evidence and expert opinions. 29,30 Chemotherapy-induced alopecia (CIA), initially reported in the 1950's, 31,32 represents one of the most common and distressing events in cancer patients. 33 Among women, 58% consider CIA the most disturbing reaction and 8% are at risk of avoiding therapy because of this toxicity.…”

Review of American and English literature for the years 1963 and 1964 (Seventeenth Rheumatism Review)

“…] Antimalarials continue to be the drugs of choice in management of discoid lupus erythematosus but there is not iinanirnity regarding their usefulness in the treatment of SLE. The dermatological indications for antimalarial therapy have been outlined and toxicity, in general, reviewed (1025). The mode of action of antimalarials is not known.…”

Parenteral Methotrexate in Psoriasis

“…In the de novo synthesis of purines tetrahydrofolic acid derivatives com¬ bine with and transfer one-carbon units into the number 2 carbon unit transfer is also mediated by a derivative of tetrahydrofolic acid.8…”