Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain

Abdulmajeed, Wahab Imam; Ibrahim, Ridwan Babatunde; Ishola, Azeez Olakunle; Balogun, Wasiu Gbolahan; Cobham, Ansa Emmanuel; Amin, Abdulbasit

doi:10.1515/jbcpp-2014-0052

Cited by 8 publications

(5 citation statements)

References 47 publications

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“…At the same time, at the familiarization session, the objects’ exploration rate by animals did not differ significantly. Since there are numerous data in the literature on working memory impairment in neuropathic pain [ 31 , 32 , 33 ], we investigated the spontaneous alternations rate in the Y-maze as an indicator of memory deficit in pain and treatment. In untreated mice with SNI, the index of working spatial memory was significantly lower than in synaptamide-treated animals (55.18 ± 2.95—“SNI” vs. 63.01 ± 2.81—“SNI + Syn”, p = 0.038) ( Figure 1 f).…”

Section: Resultsmentioning

confidence: 99%

“…In the “SNI + Syn” group, the average time spent exploring a familiar object was significantly lower than that of a novel one (4.88 ± 1.03-familiar vs. 10.42-novel, p = 0.023), while in the SNI group, animals spent approximately the same amount of time on the study of the novel and familiar objects (12.71 ± 2.21 – ”SNI” vs. 15.11 ± 3.53—“SNI + Syn”) ( Figure 1 d). Since there are numerous data in the literature on working memory impairment in neuropathic pain [ 13 , 31 , 32 ], we investigated the spontaneous alternations rate in the Y-maze as an indicator of memory deficit in pain and treatment. In untreated mice with SNI, the index of working spatial memory was significantly lower than in synaptamide-treated animals (55.18 ± 2.95—“SNI” vs. 63.01 ± 2.81—“SNI + Syn”, p = 0.038) ( Figure 1 f).…”

Section: Resultsmentioning

confidence: 99%

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Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain

Tyrtyshnaia

Bondar

Konovalova

et al. 2021

IJMS

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Neuropathic pain arises from damage or dysfunction of the peripheral or central nervous system and manifests itself in a wide variety of sensory symptoms and cognitive disorders. Many studies demonstrate the role of neuropathic pain-induced neuroinflammation in behavioral disorders. For effective neuropathic pain treatment, an integrative approach is required, which simultaneously affects several links of pathogenesis. One promising candidate for this role is synaptamide (N-docosahexaenoylethanolamine), which is an endogenous metabolite of docosahexaenoic acid. In this study, we investigated the activity of synaptamide on mice behavior and hippocampal plasticity in neuropathic pain induced by spared nerve injury (SNI). We found a beneficial effect of synaptamide on the thermal allodynia and mechanical hyperalgesia dynamics. Synaptamide prevented working and long-term memory impairment. These results are probably based on the supportive effect of synaptamide on SNI-impaired hippocampal plasticity. Nerve ligation caused microglia activation predominantly in the contralateral hippocampus, while synaptamide inhibited this effect. The treatment reversed dendritic tree degeneration, dendritic spines density reduction on CA1-pyramidal neurons, neurogenesis deterioration, and hippocampal long-term potentiation (LTP) impairment. In addition, synaptamide inhibits changes in the glutamatergic receptor expression. Thus, synaptamide has a beneficial effect on hippocampal functioning, including synaptic plasticity and hippocampus-dependent cognitive processes in neuropathic pain.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain

Tyrtyshnaia

Bondar

Konovalova

et al. 2021

IJMS

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“…With its effect on RL and TLC and its significant increase compared to the PTZ group, AMT reverses the effect of PTZ-induced memory impairment in rats, indicating its protective role against seizures and seizure-induced memory impairment. While no studies have been reported on the anticonvulsant effect or the effect on AMT memory so far, there are some reports on the inhibitory effects of AMT on neuropathic pain as well as the progression of underlying diseases associated with it (Hu et al, 2010;Abdulmajeed et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Other pharmacological properties at the central and peripheral levels include alpha-adrenergic receptor, endogenous opioid system activation, N-Methyl-D-aspartate (NMDA) receptor antagonists, gamma-Aminobutyric acid (GABA) receptor activation, reduced tumor necrosis factor (TNF) production, and prostaglandin E2 (Rico-Villademoros, Slim, Calandre, 2015). There are reports of the effect of AMT on learning and memory in experimental models of neuropathic pain in rats (Hu et al, 2010;Abdulmajeed et al, 2016).…”

Section: Effect Of Amitriptyline On Learning and Memory Consolidation...mentioning

confidence: 99%

Effect of amitriptyline on learning and memory consolidation in the male Wistar rats with an experimental model of pentylenetetrazole-induced seizure

Niazi

Mirazi

Hosseini

2023

Braz. J. Pharm. Sci.

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Amitriptyline (AMT) was developed for the treatment of chronic and neuropathic pain. There is also evidence it may be useful in the treatment of neurodegenerative disorders. In this regard, the effect of on the experimental model of seizures and memory impairment caused by seizures in rats is investigated in the present study. Seizures in Wistar rats (200-250 g) were induced by pentylenetetrazole (PTZ, 60 mg/kg, intraperitoneally (i.p.)). The anticonvulsant effect of AMT (10 and 20 mg/kg, i.p.) was evaluated in the seizure model. The effect on memory was assessed using passive avoidance (PA) learning and memory test. After behavioral tests, the animals underwent deep anesthesia and were put down painlessly. Animal serum was isolated for oxidant/antioxidant assays (malondialdehyde (MDA), and glutathione peroxidase (GPx)). Intraperitoneal injection of AMT decreased the mean number of myoclonic jerks and generalized tonic-clonic seizure (GTCS) duration and increased the mean latency of myoclonic jerk and GTCS compared to the PTZ group. Moreover, in the PA test, AMT caused a significant increase in retention latency (RL) and total time spent in the light compartment (TLC) compared to the PTZ group. Biochemical tests showed that AMT was able to significantly increase GPx serum levels and significantly reduce MDA serum levels compared to the PTZ group. Overall, this study suggests the potential neuroprotective effects of the AMT drug in a model of memory impairment caused by seizures via the mechanism of inhibition of the oxidative stress pathway.

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“…Other studies have shown that compared with traditional local anesthetics, amitriptyline has a better intensity of analgesic action and a longer duration of action ( Ryu et al, 2017 ). Moreover, it has been reported that local application of amitriptyline can produce analgesic effect on neuropathic pain, diabetic neuropathic pain and fibromyalgia ( Hiroki et al, 2017 , Abdulmajeed et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models

Zhen-long

Wang

et al. 2020

Saudi Journal of Biological Sciences

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Objective To investigate the analgesic effect of amitriptyline on neuropathic pain model rats, diabetic neuropathic pain model rats and fibromyalgia model rats. Methods The healthy male Sprague wrote – Dawley (SD) rats were taken as the research object, and they were randomly divided into model group (group A), beside the sciatic nerve and injection of 5 mm amitriptyline group (group B), beside the sciatic nerve and injection of 10 mm amitriptyline group (group C), beside the sciatic nerve and injection of 15 mm amitriptyline group (group D), intraperitoneal injection of amitriptyline group (group E). Pain induced by selective injury of sciatic nerve branches in rats, pain induced by chronic compression of sciatic nerve, diabetic neuropathic pain and fibromyalgia were conducted to determine the pain threshold of mechanical stimulation in rats after drug administration. Results The pain threshold of mechanical stimulation in the local amitriptyline group (group B, C, D) was significantly higher than that in the group A and group E at each time point after drug treatment, and the pain threshold of mechanical stimulation gradually increased with the increase of concentration. There was no statistically significant difference in mechanical stimulation pain threshold between group A and group E at each time point after drug treatment. Conclusion Para-sciatic injection of amitriptyline at different concentrations has analgesic effects on neuropathic pain, diabetic neuropathic pain and fibromyalgia in rat models, and amitriptyline directly ACTS on the local sciatic nerve.

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Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain

Abstract: The administration of amitriptyline and phenytoin can ameliorate neuronal injury, demyelination, and memory impairment associated with neuropathic pain in Wistar rats.

Cited by 8 publications

References 47 publications

Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain

Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain

Effect of amitriptyline on learning and memory consolidation in the male Wistar rats with an experimental model of pentylenetetrazole-induced seizure

Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models

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