Amitriptyline, Diazepam, and Phenobarbital Sodium in Depressed Outpatients

Rickels, Karl; Hr, Chung; Hs, Feldman; Pe, Gordon; Ea, Kelly; Cc, Weise

doi:10.1097/00005053-197312000-00006

Cited by 17 publications

(9 citation statements)

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“…As for adverse reactions, a significantly greater number of side effects was reported in patients treated with TCA by Singh et al [38], whereas a comparable likelihood of reporting side effects was observed with both BZD and TCA in 3 other studies [35,37,39].…”

Section: Systematic Review Of Rct On the Efficacy Of Bzd In The Treatmentioning

confidence: 87%

“…Seven reports directly compared BZD and TCA in patients suffering from mixed anxiety/ depressive states [34][35][36][37], neurotic depression [38,39], and DSM-III major depressive disorder with anxiety [40] (online suppl. Table 1).…”

Section: Systematic Review Of Rct On the Efficacy Of Bzd In The Treatmentioning

confidence: 99%

“…In 5 studies [35,[37][38][39][40], there were no significant differences between BZD and TCA. Results significantly favoring TCA over BZD were found in the remaining 2 studies [34,36].…”

Section: Systematic Review Of Rct On the Efficacy Of Bzd In The Treatmentioning

confidence: 99%

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Benzodiazepines as a Monotherapy in Depressive Disorders: A Systematic Review

Benasi¹,

Guidi²,

Offidani³

et al. 2018

Psychother Psychosom

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Background: The aim of this paper was to perform a systematic review and, when feasible, a meta-analysis of randomized controlled trials (RCT) which used benzodiazepines (BZD) as a monotherapy versus placebo, antidepressant drugs (AD), or both. Methods: Keyword searches were conducted for identifying RCT comparing BZD and AD, and/or placebo in the treatment of depression, using electronic databases from their inception up to April 2017. We selected reports of RCT in which BZD were compared to AD and/or placebo in the treatment of adult patients with a primary diagnosis of depressive disorder or anxious depression. When feasible, data were subjected to meta-analysis. Results: A total of 38 studies met the criteria for inclusion and were then included in the systematic review. Only 1 study concerned a newer AD, fluvoxamine. For the meta-analysis, we submitted data on response rate from 22 RCT, considering BZD versus placebo (8 comparisons) and BZD versus tricyclic antidepressants (TCA) (20 comparisons). There was a lack of significant differences as to response rate between BZD and placebo, as well as between BZD and TCA. Analysis of individual studies disclosed that, in more than half of the studies comparing BZD to TCA and/or placebo, BZD were significantly more effective than placebo and as effective as TCA. Conclusions: BZD are a therapeutic option in anxious depression and there are no indications that AD are preferable. There is a pressing need for RCT of adequate methodological quality and follow-up comparing BZD to second-generation AD and placebo in anxious depression.

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Section: Systematic Review Of Rct On the Efficacy Of Bzd In The Treatmentioning

confidence: 87%

Section: Systematic Review Of Rct On the Efficacy Of Bzd In The Treatmentioning

confidence: 99%

See 1 more Smart Citation

Benzodiazepines as a Monotherapy in Depressive Disorders: A Systematic Review

Benasi¹,

Guidi²,

Offidani³

et al. 2018

Psychother Psychosom

Self Cite

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“…However, when attempting to go beyond the HAMD total score to analyze potential differences between types of depressive patients or between antidepressant treatments, only few investigators have used subscales derived empirically (e.g. Rickels et al 1973;Prusoff et al 1976), while most have turned to detailed item analysis (e.g. Kasper et al 1995;Simon et al 1998) or have used "rational" clusters of items defined essentially by their face validity (e.g.…”

Section: Discussionmentioning

confidence: 99%

Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. A meta-analysis of data from three randomized, placebo-controlled trials

Kasper

Dienel

2002

Psychopharmacology

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“…The remaining nine studies found the two drugs to be equal in overall efficacy (Hare, 1974;Sim et al, 1971;Claghom & Kellner, 1971;General Practitioner Group, 1971;Rickels etal., 1970, Rickels et al, 1973d'Elia et al, 1974;Sterlin et al, 1970;Beaubien et al, 1970). However, within this group a number of workers noted trends for one or another agent being superior.…”

Section: Depressive Disordersmentioning

confidence: 99%