Amlodipine in the current management of hypertension

Abstract

Hypertension is the leading cause of death worldwide, affecting 1.4 billion people. Treatment options include the widely used calcium channel blockers, among which amlodipine, a dihydropyridine, has unique characteristics that distinguish it from other drugs within this class. This review aims to provide an updated overview of the evidence supporting the use of amlodipine over the past 30 years and highlights its cardiovascular benefits in current hypertension management. Amlodipine has low renal clearance (7 mL/min/mg) and long half‐life (35–50 h) and duration of action, which allows it to sustain its anti‐hypertensive effect for more than 24 h following a single dose. Additionally, blood pressure (BP) control is maintained even when a dose has been missed, providing continuous protection in case of incidental noncompliance. It has proven to reduce BP variability and successfully lower BP. Amlodipine also controls BP in patients with a systolic/diastolic BP of 130/80 mm Hg or higher, diabetes, or chronic kidney disease without worsening glycemic or kidney function. Additionally, amlodipine is a wise choice for older adults due to its ability to control BP and protect against stroke and myocardial infarction. Side effects of amlodipine include edema, palpitations, dizziness, and flushing, which are more common with the higher dose of 10 mg. Amlodipine is cost effective and predicted to be cost saving when compared with usual care.

Efficacy and Safety of Triple Therapy of Telmisartan/Amlodipine/Rosuvastatin in Patients with Dyslipidemia and Hypertension: A Multicenter Randomized Clinical Trial

“…The combination of TEL/ALD/RSV, which are the most extensively researched drugs for treating hypertension and dyslipidemia, has demonstrated significant and proven benefits, as demonstrated by a wealth of clinical trials. 16 , 17 , 18 Telmisartan, a specific angiotensin II receptor blocker with a notable preference for the angiotensin II type I receptor and an extended half-life, which renders it a highly efficient once-daily medication for BP management. It has demonstrated excellent tolerability and effectiveness in diminishing the chances of CVD and mortality in individuals at high risk.…”

Hypertension and arterial wall stiffness in clinical practice: literature review

“…В единственном исследовании HYVET, выполненном у больных АГ старше 80 лет, показано на фоне лечения индапамидом ретард снижение общей смертности на 21%, числа смертельных и несмертельных инсультов на 30%, смертельной и несмертельной сердечной недо-статочности -на 64%, смертельных инсультов -на 39% [75]. В одном из последних обзоров литературы собраны многочисленные доказательства по влиянию амлодипина у больных АГ на основные кардиологические события, подчеркивается, что амлодипин является разумным выбором для пожилых людей из-за его способности контролировать АД и защищать от инсульта и ИМ [79].…”

Pharmacokinetics of Amlodipine in Patients with Arterial Hypertension

“…Амлодипин обладает выраженным антигипертензивным эффектом и является одним из основных препаратов для лечения артериальной гипертензии (АГ) [2], а также проявляет антиангинальные свойства и применяется для симптоматического лечения стенокардии напряжения [3] и вазоспастической стенокардии [4].…”