Amlodipine-induced gingival hypertrophy

Yolcu, Alkım; Aydoğdu, İsmet

doi:10.1016/j.ejim.2020.06.023

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Fifteen months after treatment, the patient presented with no signs of recurrence. In another case report by Yolcu and Aydogdu,[ 45 ] they reported a secondary reaction of myeloid sarcoma with concurrent AIGO. They report a 63-year-old hypertensive male on amlodipine for 6 years.…”

Section: Discussionmentioning

confidence: 99%

Calcium Channel Blockers Induced Gingival Overgrowth

Damdoum

Varma

Nambiar

et al. 2022

Journal of International Society of Preventive and Community Dentistry

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Section: Discussionmentioning

confidence: 99%

Calcium Channel Blockers Induced Gingival Overgrowth

Damdoum

Varma

Nambiar

et al. 2022

Journal of International Society of Preventive and Community Dentistry

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Attenuation of L-NAME-induced Hypertension in Rats with Elettaria cardamomum–Low-dose Amlodipine Combination: A Possible Synergism of Covasodilatory Effect

Mouslem,

Almuayli,

Aldaej

et al. 2024

Pharmacognosy Magazine

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Background Hypertension is a prevalent chronic disorder that affects approximately 1.28 billion adults worldwide. In the use of amlodipine, though it is a cost-effective antihypertensive agent, it causes side effect that may lead to discontinuation of the medication. Purpose To examine the effect of the combination of Elettaria cardamomum plus a low dose of amlodipine on Nω-nitro-l-arginine methyl ester (L-NAME)-induced hypertensive rat model. Materials and Methods Thirty adult male Wistar rats were randomized into five groups of six rats, respectively. The standard control group received only normal saline (first group). The other four groups received L-NAME (40 mg/kg/day, orally) for 21 days as follows: Group 2 served as L-NAME group only; Group 3 was given E. cardamomum (400 mg/kg/day, orally); Group 4 received amlodipine (5 mg/kg/day, orally); Group 5 received E. cardamomum (400 mg/kg/day, orally) + a low dose of amlodipine (2.5 mg/kg/day, orally) and served as the combination treatment group. Twenty-four hours after the last treatment, blood pressure was measured, then blood samples were collected, rats were sacrificed, and hearts and kidneys were harvested. Serum levels of lipids, liver enzymes, urea, and creatinine were determined. Results L-NAME administration induced a notable increase in systolic, diastolic, and mean arterial blood pressure, with significant changes in biochemical parameters. However, administration of E. cardamomum alone or in combination with a low dose of amlodipine showed a better reduction in systolic and diastolic blood pressure than amlodipine alone. Consequently, effects on liver enzymes, lipid profile, and cardiorenal pathology were significantly improved with combination treatment compared with amlodipine alone. Conclusion The present study has shown that the E. cardamomum–low-dose amlodipine combination could be beneficial in lowering blood pressure without the attendant adverse effects associated with the normal dose of amlodipine alone. This could be due to covasorelaxant effects.

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Agrandamiento gingival por amlodipina: Reporte de caso

Peraza

Espinoza

2021

RSD

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El agrandamiento gingival es el aumento del volumen de la encía mayormente ocasionado por cambios inflamatorios asociados a la acumulación prolongada de biopelícula dental e inducido por fármacos, dentro de los cuales los bloqueadores de calcio como la amlodipina se destacan. La amlodipina es un fármaco de 3era generación, comúnmente usado para tratar condiciones como la hipertensión, arritmias y anginas de pecho. La prevalencia registrada para el agrandamiento gingival inducido por amlodipina, en pacientes con cardiopatías, oscila entre un 3%. El agrandamiento gingival inducido por amlodipina se debe a una interacción entre los fibroblastos gingivales, la bioquímica de los mediadores de la inflamación y los metabolitos del medicamento. A continuación, se presenta el reporte de caso de un hombre de 57 años, hipertenso, con agrandamiento gingival inducido por amlodipina, y con diagnóstico de Periodontitis estadio 3 grado C, en el que se realizó tratamiento de terapia básica periodontal y se sustituyó la amlodipina por otro fármaco antihipertensivo, adicionalmente para la resolución final del caso se realizó gingivectomía y raspado y alisado radicular a cielo abierto en bolsas recidivantes. Se concluye que la sustitución del fármaco inductor del agrandamiento gingival y una adecuada terapia periodontal puede mejorar la salud gingival del paciente y su calidad de vida.

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Amlodipine-induced gingival hypertrophy

Cited by 3 publications

References 3 publications

Calcium Channel Blockers Induced Gingival Overgrowth

Calcium Channel Blockers Induced Gingival Overgrowth

Attenuation of L-NAME-induced Hypertension in Rats with Elettaria cardamomum–Low-dose Amlodipine Combination: A Possible Synergism of Covasodilatory Effect

Agrandamiento gingival por amlodipina: Reporte de caso

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