Ammonium 1-pyrrolidinedithiocarbamate as a reagent for bismuth

Lau, Herbert K.Y.; Droll, Henry A.; Lott, Peter F.

doi:10.1016/s0003-2670(01)80104-5

Cited by 14 publications

(4 citation statements)

References 12 publications

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“…Ammonium pyrrolidinedithiocarbamate (APDC) is an excellent chelating agent for heavy metals (17,18). The structure of its anion (PDC − ) is shown in Fig.…”

Section: Radiochemistrymentioning

confidence: 99%

“…Finally, the solution containing 212 Pb(PDC) 2 was sterilized by filtration through a Gelman 0.22 μm filter and the activity determined using the HpGe detector. It should be noted that bismuth also complexes with PDC to form 212 Bi(PDC) 3 , although, based on half-life considerations, there are about 10 times fewer 212 Bi atoms than 212 Pb atoms at secular equilibrium (18). Table I.…”

Section: Radiochemistrymentioning

confidence: 99%

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Biological Effect of Lead-212 Localized in the Nucleus of Mammalian Cells: Role of Recoil Energy in the Radiotoxicity of Internal Alpha-Particle Emitters

Azure¹,

Archer²,

Sastry³

et al. 1994

Radiation Research

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The radiochemical dipyrrolidinedithiocarbamato-212 Pb(II) [ 212 Pb(PDC) 2 ] is synthesized and its effects on colony formation in cultured Chinese hamster V79 cells are investigated. The cellular uptake, biological retention, subcellular distribution and cytotoxicity of the radiocompound are determined. The 212 Pb is taken up quickly by the cells, reaching saturation levels in 1.25 h. When the cells are washed, the intracellular activity is retained with a biological half-life of 11.6 h. Gamma-ray spectroscopy indicates that the 212 Pb daughters ( 212 Bi, 212 Po and 208 Tl) are in secular equilibrium within the cell. About 72% of the cellular activity localizes in the cell nucleus, of which 35% is bound specifically to nuclear DNA. The mean cellular uptake required to achieve 37% survival is 0.35 mBq of 212 Pb per cell, which delivers a dose of 1.0 Gy to the cell nucleus when the recoil energy of 212 Bi and 212 Po decays is ignored and 1.7 Gy when recoil is included. The corresponding RBE values compared to acute external 137 Cs γ rays at 37% survival are 4.0 and 2.3, respectively. The chemical Pb(PDC) 2 is not chemotoxic at the concentrations used in this study. Because the β-particle emitter 212 Pb decays to the α-particle-emitting daughters 212 Bi and 212 Po, these studies provide information on the biological effects of α-particle decays that occur in the cell nucleus. Our earlier studies with cells of the same cell line using 210 Po (emits 5.3 MeV α particle) localized predominantly in the cytoplasm resulted in an RBE of 6. These earlier results for 210 Po, along with the present results for 212 Pb, suggest that the recoil energy associated with the 212 Bi and 212 Po daughter nuclei plays little or no role in imparting biological damage to critical targets in the cell nucleus.

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“…Ammonium pyrrolidinedithiocarbamate (APDC) is an excellent chelating agent for heavy metals (17,18). The structure of its anion (PDC − ) is shown in Fig.…”

Section: Radiochemistrymentioning

confidence: 99%

Section: Radiochemistrymentioning

confidence: 99%

Biological Effect of Lead-212 Localized in the Nucleus of Mammalian Cells: Role of Recoil Energy in the Radiotoxicity of Internal Alpha-Particle Emitters

Azure¹,

Archer²,

Sastry³

et al. 1994

Radiation Research

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show abstract

“…Following the practice of others, especially in use of ammonium 1-pyrrolidinedithiocarbamate (APDC), Lau, Droll, and Lott (1971) studied the extraction of the bismuth complex into MIBK. With (ethylenedinitrilo) tetraacetic acid disodium salt (EDTA) and an ammonium citrate buffer, only copper, silver, gold, osmium, thallium, and bismuth are extracted into MIBK.…”

Section: Discussionmentioning

confidence: 99%

“…Several methods were attempted to extract bismuth from rocks and soils for analysis by flameless atomic absorption. Of these, the procedure which resulted in the best extraction is that based on the work of Lau, Droll, and Lott (1971), who used APDC to form an extractable complex with bismuth. With such an extraction, bismuth is detectable to about 50 ppb in geologic materials.…”

Section: Discussionmentioning

confidence: 99%

Journal of Research of the U. S. Geological Survey, 1976, volume 4, issue 2

1976

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Some Aspects on Preconcentration for Neutron Activation Analysis

Yeh¹,

Lo²,

Wang³

1984

J Chinese Chemical Soc

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Kc.t' Word Jndex-Trace metals; neutron activation analysis; preconcentrution,A prcconccntration method incorporated with neutron activation analysis was . developed for the accurate determination of trace metals in biological and environmental samples. Bismuth dicthyldithiocarbamatc, thallium 'diethyldithiocarbamate.arid ammonium pyrrolidinedithiocarbamatc were used as the prcconcentraticn agents for three groups of metals. Trace metals were enriched and interfering elements such as Na, Br, P. K. etc. were-removed simultaneously during the preconcentration process so that 'the sensitivity for each metal was greatly improved. Optimal conditions for sample digestion, group preconcentratlon of trace metals and neutron activation analysis of biological and environmental samples were discussed.

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Ammonium 1-pyrrolidinedithiocarbamate as a reagent for bismuth

Cited by 14 publications

References 12 publications

Biological Effect of Lead-212 Localized in the Nucleus of Mammalian Cells: Role of Recoil Energy in the Radiotoxicity of Internal Alpha-Particle Emitters

Biological Effect of Lead-212 Localized in the Nucleus of Mammalian Cells: Role of Recoil Energy in the Radiotoxicity of Internal Alpha-Particle Emitters

Journal of Research of the U. S. Geological Survey, 1976, volume 4, issue 2

Some Aspects on Preconcentration for Neutron Activation Analysis

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