Amnion and Chorion Membranes: Potential Stem Cell Reservoir with Wide Applications in Periodontics

Gupta, Akanksha; Kedige, Suresh; Jain, Kishor S.

doi:10.1155/2015/274082

Cited by 75 publications

(82 citation statements)

References 63 publications

(79 reference statements)

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“…[3] Sabella and Stern in 1913 described its use for burnt and ulcerated skin surfaces. [2], [4] They evaluated the accelerative effect of the membrane on epithelialization and the reduction in pain in the wound. In 1940, De Röth first reported use of fetal membranes in the ocular surface.…”

Section: Historymentioning

confidence: 99%

“…He used fresh amnion and chorion as a biological dressing material for management of conjunctival defects. [2] With no ideal and practical means of preparation, sterilization and storage available at that time, the use of these membranes was very limited. [3] Kim and Tseng in 1995 gave the preservation method for maximal maintenance of biologic properties of membranes.…”

Section: Historymentioning

confidence: 99%

“…[3] Kim and Tseng in 1995 gave the preservation method for maximal maintenance of biologic properties of membranes. [2] In 1965, Dino et al demonstrated for the first time that amniotic membrane could be separated, sterilized and safely used at a later date. Since then a lot of research has been initiated to understand the true regenerative potential of this membrane.…”

Section: Historymentioning

confidence: 99%

“…Different modalities have been used in the past for the achievement of this goal which includes procedures like scaling, root planing, soft tissue curettage, and flap surgeries. [2] These procedures are used along with regenerative techniques like bone grafting, guided tissue regeneration, derivatives and substitutes of bone and biologic factors like enamel matrix proteins; but the outcomes are not predictable and are associated with high degree of variability. [1] With manifold developments in our understanding of periodontal regeneration, biologic and material sciences, complete regeneration still is an unrealistic situation in many clinical conditions due to complexity of biological events, factors and cells involved in the regenerative process of the periodontium.…”

Section: Introductionmentioning

confidence: 99%

“…These membranes have also been used in furcation defects, intrabony defects, and gingival recession coverage. [2] In this review, the various properties and uses of the placental membranes are discussed.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Human Amniotic Membrane: Hope in Periodontal Regeneration

2016

IJSR

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Several treatment modalities have been applied over the years to achieve periodontal regeneration with no predictable outcome. However, in the emerging field of regenerative medicine, the mesenchymal stem cells derived from human fetal membrane have shown promising results. The amniotic sac encloses the developing foetus through gestation and is composed of amnion and chorion membranes. The clinical application of these membranes not only maintains the structural and anatomical configuration of regenerated tissues, but also contributes to the enhancement of healing through reduction of post-operative scarring and providing a rich source of stem cells. Periodontal regeneration using amniotic membrane provides excellent predictability, improved long-term outcomes, and superior aesthetics over other treatment options.

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Section: Historymentioning

confidence: 99%

Section: Historymentioning

confidence: 99%

Section: Historymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Human Amniotic Membrane: Hope in Periodontal Regeneration

2016

IJSR

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Human Chorionic Membrane‐derived Tunable Hydrogels for Vascular Tissue Engineering Strategies

Martins,

Deus,

Gomes

et al. 2024

Adv Healthcare Materials

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One of the foremost targets in the advancement of biomaterials to engineer vascularized tissues is not only to replicate the composition of the intended tissue but also to create thicker structures incorporating a vascular network for adequate nutrients and oxygen supply. For the first time, to the best of current knowledge, a clinically relevant biomaterial is developed, demonstrating that hydrogels made from the human decellularized extracellular matrix can exhibit robust mechanical properties (in the kPa range) and angiogenic capabilities simultaneously. These properties enable the culture and organization of human umbilical vein endothelial cells into tubular structures, maintaining their integrity for 14 days in vitro without the need for additional polymers or angiogenesis‐related factors. This is achieved by repurposing the placenta chorionic membrane (CM), a medical waste with an exceptional biochemical composition, into a valuable resource for bioengineering purposes. After decellularization, the CM underwent chemical modification with methacryloyl groups, giving rise to methacrylated CM (CMMA). CMMA preserved key proteins, as well as glycosaminoglycans. The resulting hydrogels rapidly photopolymerize and have enhanced strength and customizable mechanical properties. Furthermore, they demonstrate angio‐vasculogenic competence in vitro and in vivo, holding significant promise as a humanized platform for the engineering of vascularized tissues.

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Chorion and amnion/chorion membranes in oral and periodontal surgery: A systematic review

et al. 2020

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The aim of this study was to perform a systematic review on the clinical applications where chorion membrane (CM) and amnion/chorion membrane (ACM) were used for oral tissue regeneration procedures. Selection of articles was carried out by two evaluators in Pubmed and Scopus databases, and Outcomes (PICO) method was used to select the relevant articles. Clinical studies reporting the use of CM or ACM for oral soft and hard tissue regeneration were included. The research involved 21 studies conducted on 375 human patients. Seven clinical applications of CM and ACM in oral and periodontal surgery were identified: gingival recession treatment, intrabony and furcation defect treatment, alveolar ridge preservation, keratinized gum width augmentation around dental implants, maxillary sinus membrane repair, and large bone defect reconstruction. CM and ACM were compared to negative controls (conventional surgeries without membrane) or to the following materials: collagen membranes, dense polytetrafluoroethylene membranes, platelet-rich fibrin membranes, amnion membranes, and to a bone substitute. Several studies support the use of CM and ACM as an efficient alternative to current techniques for periodontal and oral soft tissue regeneration procedures. However, further studies are necessary to increase the level of evidence and especially to demonstrate their role for bone regeneration.

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Amnion and Chorion Membranes: Potential Stem Cell Reservoir with Wide Applications in Periodontics

Cited by 75 publications

References 63 publications

Human Amniotic Membrane: Hope in Periodontal Regeneration

Human Amniotic Membrane: Hope in Periodontal Regeneration

Human Chorionic Membrane‐derived Tunable Hydrogels for Vascular Tissue Engineering Strategies

Chorion and amnion/chorion membranes in oral and periodontal surgery: A systematic review

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