Amnion epithelial cell–derived exosomes induce inflammatory changes in uterine cells

Hadley, Emily E.; Sheller‐Miller, Samantha; Saade, George R.; Salomón, Carlos; Mesiano, Sam; Taylor, Robert N.; Taylor, Brandie D.; Menon, Ramkumar

doi:10.1016/j.ajog.2018.08.021

Cited by 90 publications

(81 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Emily E. Hadley et al demonstrated that hAESC-released exosomes under control and oxidative stress conditions were taken up by myometrial, decidual, and placental cells. The exosomes from both conditions significantly increased inflammatory mediators (IL-6, IL-8, and PGE2) and activated NF-kB in maternal cells, indicating that hAESC exosomes are a novel paracrine mechanism of fetal–maternal communication [ 145 ]. In terms of preclinical treatment with hAESC exosomes, researchers presented strong evidence on wound healing and fibrosis.…”

Section: The Paracrine Effect Of Human Amniotic Epithelial Stem Cementioning

confidence: 99%

Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications

Qiu

Cui

et al. 2020

IJMS

View full text Add to dashboard Cite

Perinatal stem cells have been regarded as an attractive and available cell source for medical research and clinical trials in recent years. Multiple stem cell types have been identified in the human placenta. Recent advances in knowledge on placental stem cells have revealed that human amniotic epithelial stem cells (hAESCs) have obvious advantages and can be used as a novel potential cell source for cellular therapy and clinical application. hAESCs are known to possess stem-cell-like plasticity, immune-privilege, and paracrine properties. In addition, non-tumorigenicity and a lack of ethical concerns are two major advantages compared with embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). All of the characteristics mentioned above and other additional advantages, including easy accessibility and a non-invasive application procedure, make hAESCs a potential ideal cell type for use in both research and regenerative medicine in the near future. This review article summarizes current knowledge on the characteristics, therapeutic potential, clinical advances and future challenges of hAESCs in detail.

show abstract

Section: The Paracrine Effect Of Human Amniotic Epithelial Stem Cementioning

confidence: 99%

Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications

Qiu

Cui

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Labor is considered a state of systemic [15‐19] and local [20‐31] physiological inflammation [32‐35]. The latter concept is supported by consistent evidence showing that labor is characterized by an increase in cellular and soluble inflammatory mediators in the cervix [32,36‐48], myometrium [37‐38,40,49‐52], chorioamniotic membranes [38,40,53‐59], and decidual tissues (i.e. maternal–fetal interface) [38,40,53‐54,57,60‐63].…”

Section: Introductionmentioning

confidence: 99%

The effects of advanced maternal age on T-cell subsets at the maternal–fetal interface prior to term labor and in the offspring: a mouse study

Levenson

Romero

Garcia‐Flores

et al. 2020

Clinical and Experimental Immunology

View full text Add to dashboard Cite

Summary Women who conceive at 35 years of age or older, commonly known as advanced maternal age, have a higher risk of facing parturition complications and their children have an increased risk of developing diseases later in life. However, the immunological mechanisms underlying these pathological processes have yet to be established. To fill this gap in knowledge, using a murine model and immunophenotyping, we determined the effect of advanced maternal age on the main cellular branch of adaptive immunity, T cells, at the maternal–fetal interface and in the offspring. We report that advanced maternal age impaired the process of labor at term, inducing dystocia and delaying the timing of delivery. Advanced maternal age diminished the number of specific proinflammatory T‐cell subsets [T helper type 1 (Th1): CD4+IFN‐γ+, CD8+IFN‐γ+ and Th9: CD4+IL‐9+], as well as CD4+ regulatory T cells (CD4+CD25+FoxP3+ T cells), at the maternal–fetal interface prior to term labor. Advanced maternal age also altered fetal growth and survival of the offspring in early life. In addition, infants born to advanced‐age mothers had alterations in the T‐cell repertoire but not in CD71+ erythroid cells (CD3−CD71+TER119+ cells). This study provides insight into the immune alterations observed at the maternal–fetal interface of advanced‐age mothers and their offspring.

show abstract

“…According to their diameter, EVs can be classified into two general subgroups: 1) small EVs (<200nm), and 2) medium/large EVs (>200 nm) [10]. Recent studies have identified EVs as critical players in intercellular communication under various physiological and pathological conditions such as neurodegenerative diseases, cancer, preterm birth, angiogenesis, immune responses, and viral infections [3,[13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Cigarette Smoke Condensate Exposure Changes RNA Content of Extracellular Vesicles Released from Small Airway Epithelial Cells

Corsello

Kudlicki

Garofalo

et al. 2019

Cells

View full text Add to dashboard Cite

Exposure to environmental tobacco smoke (ETS) is a known risk factor for the development of chronic lung diseases, cancer, and the exacerbation of viral infections. Extracellular vesicles (EVs) have been identified as novel mediators of cell–cell communication through the release of biological content. Few studies have investigated the composition/function of EVs derived from human airway epithelial cells (AECs) exposed to cigarette smoke condensate (CSC), as surrogates for ETS. Using novel high-throughput technologies, we identified a diverse range of small noncoding RNAs (sncRNAs), including microRNA (miRNAs), Piwi-interacting RNA (piRNAs), and transfer RNA (tRNAs) in EVs from control and CSC-treated SAE cells. CSC treatment resulted in significant changes in the EV content of miRNAs. A total of 289 miRNAs were identified, with five being significantly upregulated and three downregulated in CSC EVs. A total of 62 piRNAs were also detected in our EV preparations, with five significantly downregulated and two upregulated in CSC EVs. We used TargetScan and Gene Ontology (GO) analysis to predict the biological targets of hsa-miR-3913-5p, the most represented miRNA in CSC EVs. Understanding fingerprint molecules in EVs will increase our knowledge of the relationship between ETS exposure and lung disease, and might identify potential molecular targets for future treatments.

show abstract

Amnion epithelial cell–derived exosomes induce inflammatory changes in uterine cells

Abstract: In vitro, amnion epithelial cell exosomes lead to an increased inflammatory response in maternal uterine cells whereas placental cells showed refractoriness. Fetal cell exosomes may function to signal parturition by increasing maternal gestational cell inflammation.

Cited by 90 publications

References 92 publications

Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications

Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications

The effects of advanced maternal age on T-cell subsets at the maternal–fetal interface prior to term labor and in the offspring: a mouse study

Cigarette Smoke Condensate Exposure Changes RNA Content of Extracellular Vesicles Released from Small Airway Epithelial Cells

Contact Info

Product

Resources

About