Amnionitis with Ureaplasma urealyticum or other microbes leads to increased morbidity and prolonged hospitalization in very low birth weight infants

Kirchner, Lieselotte; Helmer, Hanns; Heinze, Georg; Wald, Martin; Brunbauer, M.; Weninger, M.; Zaknun, Daniela

doi:10.1016/j.ejogrb.2006.09.013

Cited by 59 publications

(40 citation statements)

References 31 publications

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“…UP is more commonly associated with preterm birth than U. urealyticum, and serovar 3 is the most common ureaplasma serovar isolated from women, men, pregnant women, and infertile couples (11)(12)(13). This ureaplasma colonization model in fetal sheep replicates the chronic and indolent human fetal exposure to ureaplasmas that can result in preterm birth (14) or may be tolerated by the pregnancy without overt pathology (15). As in the human, fetal sheep colonized with ureaplasmas can have induced lung maturation and indicators of chronic lung inflammation (16).…”

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confidence: 96%

Ventilation-Mediated Injury After Preterm Delivery of Ureaplasma parvum Colonized Fetal Lambs

et al. 2010

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Ureaplasma species are the microorganisms most frequently isolated from women with preterm birth and are associated with an increased risk of bronchopulmonary dysplasia. Initiation of ventilation with high tidal volumes (V T ) causes lung injury and inflammation. We investigated whether antenatal colonization with Ureaplasma parvum serovar 3 (UP) would alter the inflammatory response to mechanical ventilation of preterm lambs. Merino ewes were given intraamniotic injections of UP at 55-d gestation, and the lambs were surgically delivered at 128 Ϯ 1 d gestation and assigned to three groups: 1) gentle ventilation (GV), 2) high V T ventilation, or 3) unventilated control. Lambs delivered from noncolonized ewes were assigned to parallel groups. GV lambs received surfactant before ventilation with a V T of 7 mL/kg, positive end expiratory pressure (PEEP) 5 cm H 2 O . High V T lambs received no PEEP and escalating V T to 15 mL/kg by 15 min. At 15 min, surfactant was given, V T was reduced to 7 mL/kg, and PEEP was increased to 5 cm H 2 O. Monocytes in bronchoalveolar lavage were increased by UP, but colonization did not affect lung function. High V T ventilation increased Egr-1 signaling, proinflammatory cytokine expression, and injury scores compared with GV. Antenatal colonization with UP did not change lung function or modulate the lung injury and inflammation caused by high V T ventilation. (Pediatr Res 67: 630-635, 2010)

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Ventilation-Mediated Injury After Preterm Delivery of Ureaplasma parvum Colonized Fetal Lambs

et al. 2010

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“…Ureaplasma urealyticum and Mycoplasma hominis are the two most common organisms isolated from amniotic fluid and infected placentas (42). Transmission of U. urealyticum increases as gestational age decreases and with the duration of ruptured membranes (30,38).…”

Section: Ureaplasma Modelmentioning

confidence: 99%

Animal models of bronchopulmonary dysplasia. The preterm baboon models

Yoder

Coalson

2014

American Journal of Physiology-Lung Cellular and Molecular Phys

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Yoder BA, Coalson JJ. Animal models of bronchopulmonary dysplasia. V. The preterm baboon models. Am J Physiol Lung Cell Mol Physiol 307: L970 -L977, 2014. First published October 3, 2014 doi:10.1152/ajplung.00171.2014.-Much of the progress in improved neonatal care, particularly management of underdeveloped preterm lungs, has been aided by investigations of multiple animal models, including the neonatal baboon (Papio species). In this article we highlight how the preterm baboon model at both 140 and 125 days gestation (term equivalent 185 days) has advanced our understanding and management of the immature human infant with neonatal lung disease. Not only is the 125-day baboon model extremely relevant to the condition of bronchopulmonary dysplasia but there are also critical neurodevelopmental and other end-organ pathological features associated with this model not fully discussed in this limited forum. We also describe efforts to incorporate perinatal infection into these preterm models, both fetal and neonatal, and particularly associated with Ureaplasma/Mycoplasma organisms. Efforts to rekindle the preterm primate model for future evaluations of therapies such as stem cell replacement, early lung recruitment interventions coupled with noninvasive surfactant and high-frequency nasal ventilation, and surfactant therapy coupled with antioxidant or anti-inflammatory medications, to name a few, should be undertaken.baboon; bronchopulmonary dysplasia; lung; preterm infant; ureaplasma OF THE NEARLY 4,000,000 annual births in the United States, ϳ1% (ϳ40,000) occur at Ͻ29-wk gestation. Advances in prenatal and neonatal care have contributed to marked improvements in survival rates for these extremely immature infants, with many centers reporting survival rates Ͼ90% for infants in the 25-to 28-wk range (71). However, increasing survival of these fragile infants has been accompanied by high rates of bronchopulmonary dysplasia (BPD), the most common morbidity affecting extremely preterm infants (66,71,96). Much of the progress in improved neonatal care, particularly management of underdeveloped preterm lungs, including approaches to mechanical ventilation, surfactant therapy, and application of noninvasive respiratory support, has been derived through investigations of multiple animal models, including the neonatal baboon (Papio species). In this article we will highlight how primate models, particularly the preterm baboon model at both 140 days and 125 days gestation (term equivalent 185 days), have advanced our understanding and management of the immature human infant with neonatal lung disease; identify limitations to this and other animal models in the quest to prevent BPD; and suggest future directions to improve animal modeling and translational research to further improve outcomes. 140-Day Model ("Old BPD")The first long-term animal model for neonatal BPD in the 140-day premature baboon was developed in the early 1980s (19,26). At that time surfactant replacement therapy had not been approved for human use. Additi...

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“…Although Ureaplasma spp., specifically U. urealyticum, are commensal organisms of the urogenital tract of sexually active women, 7 U. urealyticum is the most common microbe isolated from amniotic fluid of women at risk for preterm delivery 5 and has been associated with abortion, chorioamnionitis, low birth weight, pneumonia, and chronic lung disease in infants. 5,7 As in cattle, the conditions needed for Ureaplasma spp.…”

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confidence: 99%

“…5,7 As in cattle, the conditions needed for Ureaplasma spp. to produce reproductive disease in humans remain unclear.…”

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confidence: 99%

“…to produce reproductive disease in humans remain unclear. 5 Although U. urealyticum has not been associated with arthritis in human fetuses, it has been isolated from cases of arthritis and septic osteomyelitis in human neonates 7,8,11 and is a common cause of severe, chronic, erosive polyarthritis in humans with primary immune deficiencies. 1 This association with human arthritis suggests that Ureaplasma spp.…”

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confidence: 99%

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Destructive Polyarthropathy in Aborted Bovine Fetuses: A Possible Association with Ureaplasma diversum Infection?

Himsworth¹,

Hill

Huang³

et al. 2009

Veterinary Pathology

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Abstract. Severe destructive polyarthropathy with fibrillation and erosion of articular cartilage, deformation of articular surfaces, and proliferation of periarticular soft tissue was diagnosed in 5 bovine fetuses aborted in the last trimester. There was involvement of a single coxofemoral joint in 2 fetuses, both elbows, and a stifle in 1, both stifles and tarsal joints in another, and, in the most severely affected fetus, both hips, stifles, and shoulders as well as 1 carpus. In affected joints, the articular cartilage was irregularly reduced in thickness and contained fibrovascular tissue and, in some cases, inflammatory cells and fibrin. Four of 5 fetuses had microscopic placentitis; all had mild lymphoplasmacytic conjunctivitis. Ureaplasma spp. was identified in 4 cases by polymerase chain reaction or culture. Fetal arthropathy and Ureaplasma diversum-associated joint pathology have not been previously reported in the veterinary literature; however, other Ureaplasma spp. are known to cause reproductive disease and arthritis in humans.

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Amnionitis with Ureaplasma urealyticum or other microbes leads to increased morbidity and prolonged hospitalization in very low birth weight infants

Cited by 59 publications

References 31 publications

Ventilation-Mediated Injury After Preterm Delivery of Ureaplasma parvum Colonized Fetal Lambs

Ventilation-Mediated Injury After Preterm Delivery of Ureaplasma parvum Colonized Fetal Lambs

Animal models of bronchopulmonary dysplasia. The preterm baboon models

Destructive Polyarthropathy in Aborted Bovine Fetuses: A Possible Association with Ureaplasma diversum Infection?

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