“…A wide variety of limb abnormalities can result, including amputation, acrosyndactyly, oligodactyly, talipes equinovarus or simply soft-tissue constriction. Other associated abnormalities include cleft lip and palate, craniofacial disruptions, neural tube defects, cranial defects, scoliosis and body-wall defects, such as abdominoschisis and extrathoracic heart [14]. It has been postulated that the timing of amnion rupture during gestation may determine the type of resultant abnormalities.…”