Amniotic Fluid and the Fetal Mucosal Immune System

Nowicki, Stella; Goldblum, Randall M.

doi:10.1016/b978-0-12-415847-4.00115-4

Cited by 3 publications

(3 citation statements)

References 96 publications

(101 reference statements)

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“…Four out of ten bitches had regular prophylaxis with core vaccines (ID. 1,4,8,9). All dogs were monitored throughout the reproductive cycle, from proestrus to parturition, as routine [38].…”

Section: Clinical Recordsmentioning

confidence: 99%

“…During intra-uterine life, the placenta defends the embryo and foetus from exposure to foreign pathogens, and amniotic fluid (AF) modulates the maternal immune response to prevent the rejection of the foetus [ 4 ]. In dogs, the neonatal period is a critical age, with infectious diseases described as the primary cause of newborn mortality [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Canine Amniotic Fluid at Birth Holds Information about Neonatal Antibody Titres against Core Vaccine Viruses

Groppetti,

Pecile,

Filipe

et al. 2024

Veterinary Sciences

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There is a growing interest in the composition of amniotic fluid (AF) in both humans and animals. In addition to its nutritional and protective functions for the foetus, current knowledge demonstrates that AF also serves advanced diagnostic, prognostic, and therapeutic roles. Newborn dogs have an underdeveloped immune system, making them highly susceptible to dangerous pathogens such as canine parvovirus (CPV-2), canine infectious hepatitis virus (CAdV-1), and canine distemper virus (CDV), thus exposing them to a high risk of mortality in the first weeks of life. Immunoglobulins G (IgGs) represent the only antibody isotype capable of crossing the placenta in a small amount and have been detected also in canine AF. The primary aim of this study was to investigate the reliability of AF collected at birth as a marker of passive immunity in canine species. For this purpose, total and specific IgGs against CPV-2, CAdV-1, and CDV were investigated and quantified in both maternal plasma and AF collected at the time of caesarean section. The vaccination status of the bitches was also taken into consideration. Since the immune system can be influenced by gestational age, with preterm infants having immature innate and adaptive immunity, IgG concentrations were correlated with amniotic lecithin, sphingomyelin, cortisol, surfactant protein A, and pentraxin 3 levels. In a previous study from our group on foetal maturity these molecules were measured in the same samples. Finally, correlations between their amniotic content and neonatal outcomes were investigated. This study demonstrates that AF analysis at birth can provide valuable insights into neonatal immunity in puppies, offering a non-invasive method to detect potential early health risks, for improved puppy care and management.

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Section: Clinical Recordsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Canine Amniotic Fluid at Birth Holds Information about Neonatal Antibody Titres against Core Vaccine Viruses

Groppetti,

Pecile,

Filipe

et al. 2024

Veterinary Sciences

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“…The protective anti-inflammatory response, crucial for mitigating damage, is significantly hindered by glycation [28]. In our study, we examined the impact of Stevia plant extract on IL-10, a key anti-inflammatory cytokine.…”

Section: Production Of Cytokinementioning

confidence: 99%

Unlocking the Therapeutic Potential of Stevia rebaudiana Bertoni: A Natural Antiglycating Agent and Non-Toxic Support for HDF Cell Health

Shahu,

Kumar,

Ali

et al. 2023

Molecules

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Sugar carbonyl groups interact with protein amino groups, forming toxic components referred to as advanced glycation end products (AGEs). The glycation system (BSA, a model protein, and fructose) was incubated for five weeks at 37 °C in the presence and absence of Stevia leaf extract. The results indicated that the leaf extract (0.5 mg/mL) decreased the incidence of browning (70.84 ± 0.08%), fructosamine (67.27 ± 0.08%), and carbonyl content (64.04 ± 0.09%). Moreover, we observed an 81 ± 8.49% reduction in total AGEs. The inhibition of individual AGE (argpyrimidine, vesper lysine, and pentosidine) was ~80%. The decrease in the protein aggregation was observed with Congo red (46.88 ± 0.078%) and the Thioflavin T (31.25 ± 1.18%) methods in the presence of Stevia leaf extract. The repercussion of Stevia leaf extract on DNA glycation was examined using agarose gel electrophoresis, wherein the DNA damage was reversed in the presence of 1 mg/mL of leaf extract. When the HDF cell line was treated with 0.5 mg/mL of extract, the viability of cells decreased by only ~20% along with the same cytokine IL-10 production, and glucose uptake decreased by 28 ± 1.90% compared to the control. In conclusion, Stevia extract emerges as a promising natural agent for mitigating glycation-associated challenges, holding potential for novel therapeutic interventions and enhanced management of its related conditions.

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Secretory immune system in human embryonic and fetal development: Joining chain and immunoglobulin transport (Review)

Ben‐Hur

Gurevich²,

Elhayany³

et al. 2004

Int J Mol Med

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Amniotic Fluid and the Fetal Mucosal Immune System

Cited by 3 publications

References 96 publications

Canine Amniotic Fluid at Birth Holds Information about Neonatal Antibody Titres against Core Vaccine Viruses

Canine Amniotic Fluid at Birth Holds Information about Neonatal Antibody Titres against Core Vaccine Viruses

Unlocking the Therapeutic Potential of Stevia rebaudiana Bertoni: A Natural Antiglycating Agent and Non-Toxic Support for HDF Cell Health

Secretory immune system in human embryonic and fetal development: Joining chain and immunoglobulin transport (Review)

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